Endocrine Receptors And Signaling Pathways (Kruse)

Question 1

Alpha & beta adrenergic receptors, glucagon receptors, PTH receptors, FSH receptors, LH receptors and ACTH receptors are all this type of receptor:

Answer 1

GPCR

Question 2

This G protein subtype activates AC –> cAMP

This G protein subtype activates PLC –> IP3, DAG, increases cytoplasmic Ca2+

Answer 2

Gs

Gq

Question 3

Androgen, estrogen, progesterone, thyroid hormone, retinoic acid, and vitamin D bind what kind of receptors?

Answer 3

Nuclear

Question 4

This nuclear receptor domain is the most variable among nuclear receptors

Answer 4

AF1

Question 5

This nuclear receptor domain is highly conversed and functions to recognize and bind to specific sequences of DNA (HRE’s) upstream of the target gene. Also plays a role in receptor dimerization

Answer 5

DBD

Question 6

This nuclear receptor domain selectively binds to agonists or antagonists and confers ligand-dependent activation.

Answer 6

LBD

Question 7

Glucocorticoid receptors, Mineralocorticoid receptors, estrogen receptors, progesterone receptors, and androgen receptors belong to this class of nuclear receptors

Answer 7

Classic steroid nuclear receptors

Question 8

Thyroid hormone, vitamin D, retinoids, lipids, and FA’s bind this subset of nuclear receptors

Answer 8

Orphan receptors

Question 9

list the receptor type for the following:
B-adrenergic
LH, FSH, TSH
Glucagon
PTH, PTHrP
ACTH
GHRH

Answer 9

Galpha-s –> stimulation of cAMP

Question 10

List the receptor type for the following:
a-adrenergic
Somatostatin

Answer 10

Galpha-i –> inhibit cAMP, activate K and Ca channels

Question 11

List the receptor type for the following:

TRH, GnRH

Answer 11

Galpha-q, Galpha-11 –> PLC, DAG, IP3, PKC, voltage-gated Ca channels

Question 12

Insulin receptor is this type:

Answer 12

Receptor tyrosine kinase –> IRS1-4 effectors; MAPkinases, PI3kinases, RSK signaling pathways

Question 13

GH and Prolactin receptors are this type:

Answer 13

Cytokine receptor-linked kinase –> Jak, tyrosine kinase effectors; STAT, Map kinase, PI3-kinase, IRS-1 and IRS-2 signaling pathways

Question 14

TGF-b is this receptor type

Answer 14

Serine kinase –> SMAD signaling pathways

Question 15

ER, AR, PR, and GR are __ steroid receptors

Answer 15

Homodimer

Question 16

Thyroid hormone receptor, vitamin D receptor, retinoic acid receptor, and PPAR are ___ receptors

Answer 16

Heterodimer