Endocrine: Pituitary

Question 1

Recombinant growth hormones and their indications

Answer 1

SOMATREM
SOMATROPIN

INDICATIONS:

1. Pituitary dwarfism
2. AIDS Wasting
3. Short bowel syndrome dependant on TPN

Question 2

Recombinant GHRH and indiactions

Answer 2

SERMORELIN
HEXARELIN

Pituitary dwarfism

Question 3

GH Receptor antagonist and Indication

Answer 3

PEGVISOMANT

Acromegaly

Question 4

Recombinant IGF 1 and IGF 1 binding protein 3 complex and indications?

Answer 4

MECA SERMIN

Growth failure not responsive to GH (cuz due to IGF deficiency)

Question 5

Somatostatin analogues

Answer 5

OCTreotide
LANreotide (i.m.)
VAPreotide
PASIreotide (indicated in Cushing’s)

Seglitide

Question 6

Somatostatin indications

Answer 6

(SOMATO)statin

Secretory diarrhoea
Oesophageal varices (because vasoconstrictor)
Malignancy of pancreas : insulinoma and glucagonoma
* Acromegaly *
TSH secreting adenoma
OD of sulphonylurea

Question 7

Dopamine (PIH) D2 agonists and indications

Answer 7

Bromocriptine, pergolide,
CABERGOLINE
QUINAGOLIDE

Indications: DOPAMine

Diabetes mellitus type 2 (only bromocriptine)
Oversecretion of prolactin (infertility and galactorrhoea)
Parkinsonism
Acromegaly
Milk secretion inhibition (if newborn is dead)

Question 8

Gonadorelins meaning and examples

Answer 8

Synthetic GnRH

LEUPROLIDE
Nafarelin- also nasal
Busurelin- also nasal
Goserelin- s.c. Implant
Histrelin
Deslorelin
Triptorelin

Question 9

Gonadorelins indications

Answer 9

PULSATING ADMINISTRATION (increases GnRH)

1. Anovulatory cycles
2. Hypogonadotropic hypogonadism
3. Cryptorchidism
4. Delayed puberty

CONTINUOUS (decreases GnRH)

1. Precocious puberty
2. PCOD
3. Prostatic cancer
4. Fibroids (you read this in anatomy)
5. Endometriosis

Question 10

GnRH antagonists and indications

Answer 10

Cetrorelix
Abarelix
Ganirelix
Dagarelix

Indications:
Endometriosis
Fibroids
IVF me controlled ovum-stimulation