CNS- Antipsy, Antidep, Antiep, Sed-Hyp

Question 1

H: Drugs to treat ACUTE MANIA

Answer 1

DOC: lithium

Antiepileptics:

1. Valproate
2. Carbamazepine
3. Topiramate

Atypical Antipsychotics

1. Asenapine, olanzapine, quetiapine
2. Aripiprazole
3. Risperidone, Ziprasidone

Lithium also prevents recurrent mania and to a lesser extent recurrent depression

Question 2

Drugs for prevention of depression of bipolar

Answer 2

Lamotrigine

Question 3

Typical antipsychotics MOA and examples

Answer 3

D2 receptor blockade

Examples:
STRONG
1. Haloperidol
2. Droperidol
3. Fluphenazine

INTERMEDIATE

1. Chlorprothixine
2. Thiothixine

WEAK

1. Chlorpromazine
2. Thioridazine

Question 4

H: drugs approved for OCD

Answer 4

Clomipramine

Fluoxetine
Flavoxamine (also for children)
Setraline

Question 5

ADRs of lithium

Answer 5

Mm: LITHIUM

Leukocytosis
Increased neutrophils💜
Tremors❤️
Hypothyroidism💜
Increased
Urine (polyuria)
Mothers C/I -EBSTEINS ANOMALY (tricuspid atresia)

Question 6

ADRs of Valproate

Answer 6

Mm: VALPROATE

Vomiting
Alopecia, curling of hair
Liver toxicity💚
Pancreatitis💚, PCOD💜
Rash
Obesity❤️
Agranulocytosis 
Tremors❤️, teratogenic
Eeeeeee

Question 7

Serotonin syndrome : C/P

Answer 7

Mm: HARM

Hyperpyrexia, hypertension
Agitation, abdominal cramps
Rigidity
Myoclonus

Question 8

SSRIs side effects

Answer 8

1. Nausea, vomiting
2. Sexual
3. Sleep impairment
4. Akathisia
5. Angina (rare)
6. Increased PT

Question 9

SSRIs that don’t block cyp enzymes

Answer 9

Citalopram

Escitalopram