Endocrine Pharm w/o DM

Question 1

Propylthiouracil (PTU), methimazole MoA

Answer 1

Block thyroid peroxidase, inhibiting the oxidation of iodide and the organification (coupling) of iodine -> inhibition of thyroid hormone synthesis.
Propylthiouracil also blocks 5′-deiodinase -> decreases peripheral conversion of T4 to T3.

Question 2

Which drug for hyperthyroidism can be used for pregnancy?

Answer 2

Propylthiouracil

Question 3

Toxicity of Propylthiouracil, methimazole

Answer 3

agranulocytosis (rare), aplastic anemia, hepatotoxicity.

Question 4

conivaptan, tolvaptan MoA and use

Answer 4

SIADH, ADH antagonist at V2-receptor.

Question 5

Demeclocycline MoA

Answer 5

ADH antagonist

Question 6

Demeclocycline use

Answer 6

SIADH

Question 7

Demeclocycline tox

Answer 7

Nephrogenic DI, photosensitivity, abnormalities of bone and teeth.

Question 8

Fludrocortisone MoA

Answer 8

Synthetic analog of aldosterone with little glucocorticoid effects.

Question 9

Fludrocortisone use

Answer 9

Mineralocorticoid replacement in 1° adrenal insufficiency.

Question 10

What drug has similar side effects to glucocorticoids; also edema, exacerbation of heart failure, hyperpigmentation.

Answer 10

Fludricortisone

Question 11

Cinacalcet MoA

Answer 11

Sensitizes Ca2+-sensing receptor (CaSR) in parathyroid gland to circulating Ca2+ -> decreases PTH.

Question 12

Cinacalcet use

Answer 12

1° or 2° hyperparathyroidism.

Question 13

Cinacalcet toxicity

Answer 13

Hypocalcemia