Endocrine Part 3 Flashcards
Moderate to intensely hyper chromatic with eosinophilic staining cytoplasm.
Parathyroid chief cells
Polygonal cells with centrally located, round nuclei. Also have secretory granules, sometimes clear d/t glycogen storage
Chief cells of the parathyroid glands
Light to moderately eosinophilic staining with abundant amount of cytoplasm
Oxyphil cells
One of most common endocrine d/o; important cause of hypercalcemia
Primary hyperparathyroidism
What is the most common underlying cause of hyperparathyroidism
Adenoma
Follicular formation, no inc mitotic figures, no anaplasia, lack of adipose
Parathyroid adenoma
Caused by any condition that gives rise to chronic hypercalcemia; leads to compensatory over activity of the parathyroid glands
Secondary parathyroidism
Over activity of the parathyroid results in (3)
Inc cell division, inc cell number, eventual hyperplasia
Most common cause of secondary hyperparathyroidism
Renal failure
What is the least common form of primary hyperparathyroidism?
Parathyroid carcinoma
Second most common form of primary hyperparathyroidism
Parathyroid hyperplasia
Reduced adipose tissue but all normal parathyroid cell types present
Parathyroid hyperplasia
Tumors secrete PTH, produce hyperparathyroidism and hypercalcemia
Parathyroid carcinoma
High serum calcium levels, severe bone dz, renal stones
Parathyroid carcinoma
Nests of neoplastic cells not pleomorphic. Bands of fibrous tissue between the nests.
Parathyroid carcinoma
