Endocrine Neoplasms

Question 1

Adrenal medullary cell neoplasm

Answer 1

Phaeochromocytoma

Question 2

Stomach gastrin-secreting cell neoplasm

Answer 2

Gastrinoma

Question 3

Peptide-secreting pituitary cell neoplasm

Answer 3

Pituitary adenoma/carcinoma

Question 4

Serotonin-secreting cell neoplasm

Answer 4

Carcinoid tumour

Question 5

Thyroid follicular cell neoplasm

Answer 5

Thyroid adenoma/carcinoma

Question 6

Thyroid calcitonin-secreting cell neoplasm

Answer 6

Medullary thyroid carcinoma

Question 7

Potential result of carcinoid tumour

Answer 7

Carcinoid syndrome with diarrhoea, etc.

Question 8

Feature of neuroendocrine tumours

Answer 8

Contain neurosecretory granules in cytoplasm

Question 9

Test for neurosecretory tumour

Answer 9

Test for chromogranin using anti-chromogranin antibodies

Question 10

Features of squamous cell carcinoma

Answer 10

Very aggressive, quickly grows and metastasises widely

Question 11

Commonest site of squamous cell carcinoma and risk factor

Answer 11

• lung

* smoking

Question 12

Possible consequences of squamous cell carcinoma

Answer 12

May secrete hormones with ACTH and ADH being the commonest

Question 13

3 effects of a pituitary tumour

Answer 13

1. Compress and destroy surrounding pituitary tissue causing hypopituitarism
2. Secrete active hormone leading to hormonal excess
3. Compression of adjacent structures eg. optic nerve

Question 14

Neoplasm of adrenal cortex corticosteroid secreting cells

Answer 14

Adrenal adenoma/carcinoma