Endocrine Health Flashcards
1
Q
Describe the stages of the Hypothalamus-Pituitary-Tyroid axis?
A
Thyrotropin-release hormone (TRH) - Hypothalamus
stimulates
Thyroid-stimulating hormone (TSH)
stimulates
Thyroid hormone release T4 (around 90%) and T3
2
Q
What enzymes are key for the tyroid?
A
Selenoproteins
Deiodinase - 1 & 2 convert T4 to T3
Deiodinase 3 - converse T4 to Reverse T3
3
Q
What is T3
A
Triiodothyronine
4x the ‘strength’ of T4
Increases grow, bone and CNS development
Increases BMR, heart rate and activates the metabolism.
4
Q
What is T4?
A
Thyroxine
Weak thyroid activity ‘inactive form
5
Q
What is Reverse T3
A
Biologically inactive - one hypothesis is it protects tissues from excess thyroid hormones
6
Q
A