Endocrine Drugs

Question 1

Describe the mechanism of action of metformin.

Answer 1

1. Increases activity of AMP-dependent protein kinase (AMPK)
   a. This inhibits gluconeogenesis
2. Also reduces insulin resistance

Question 2

What are the 3 main types of drug you can use to treat type 2 diabetes?

Give an example of each.

Answer 2

Biguanides (e.g. Metformin)
Sulphonylureas (e.g. Gliclazide)
GLP1 agonists (e.g. Liraglutide)