Endocrine drugs

Question 1

What is an endocrine drug?

Answer 1

Endocrine drugs are agents directed to a malfunctioning endocrine path.

Question 2

What is endocrine system?

Answer 2

It is the collection of glands that produce hormones that regulate numerous physiological functions of the body such as growth, metabolism, sexual functions etc.

Question 3

What are hormones?

Answer 3

-made in glands or cells
-activates physiological response
-distant or local target tissue receptors
-cell to cell communication molecules

Question 4

Hormonal regulation

Answer 4

-Reproduction, fertility, sexual function
-response to environmental situations
-Growth and development
-Maintenance of normal homeostasis

Question 5

Amine hormones

Answer 5

-derived from the amino acid tyrosine
-include catecholamines (dopamine) and thyroid hormones
-stored until secreted
*Receptor locations
Surface(dopamine)/ Intracellular (nuclear; T3 & T4)

Question 6

Endocrine drigs

Answer 6

-Hormones are pharmacologically classified as drugs
-can be natural, semi-synthetic or synthetic compounds
-indications:
A. Replacement therapy
B. Treatment for certain disorders
C. Diagnosticpurposes

Question 7

Antithyroid drugs

Answer 7

Used to lower the functional capacity of the hyperactivethyroid gland and have the following directions of action:
1. Inhibit thyroid-stimulating hormone secretion by anterior pituitary: Iodine
Diiodthyrosine
2. Inhibit thyroid hormones synthesis in the thyroid gland:
Mercazolyl
Propylthiouracil
3. Inhibit iodine trapping by the thyroid gland: Potassium perchlorate
4. Destroy thyroid tissue:
Radioactive iodine

Question 8

Mineralocorticoid drugs

Answer 8

Desoxycorticosterone,acetate, desoxycorticosterone trimethylacetate, flourhydrocortisone acetate.

Question 9

Antagonists of mineralocorticoids

Answer 9

Inhibitors of synthesis -metyrapone
Tissue receptors blockers- spironolactone

Question 10

Hormonal contraceptives

Answer 10

Oral- combinations of estrogens and progestins:
-monophasic combination tablets -rigevidon, minisiston, marvelon
Biphasic combination tablets- anteovin
Triphasic combination tablets-triquilar, trisiston, tri-regol
Parenteral contraceptives- medroxyprogesterone acetate [depo-provera]

Implantable contraceptives- levonorgestrel [Norplant system]