Endocrine disorders

Question 1

TRH secretion from hypothalamus is stimulated by ______ cold and inhibited by _______

Answer 1

cold, stress

Question 2

if TBG levels increase (pregnancy, OCP), total T4 ____________ (decreases / stays normal / increases) but free T4 _____________ (decreases / stays normal / increases)

Answer 2

• increases

- stays normal

Question 3

nephrotic syndrome and androgen use __________ (decrease / increase) TBG levels, leading to ____________ (decreased / normal / increased) total T4 but ____________ (decreased / normal / increased) free T4

Answer 3

• decrease
• decreased
• normal

Question 4

what could be the cause(s) of decreased Ca2+ with increased PTH?

Answer 4

a hyperparathyroidism secondary to malnutrition, malabsorption, renal disease, or calcium-wasting drugs

Question 5

what is the treatment for 17a-hydroxylase deficiency?

Answer 5

• cortisol replacement to achieve ACTH suppression
• estrogen-progesterone replacement given to genotypic females at puberty
• genotypic males may have reconstructive surgery of genitals

Question 6

what is the treatment for 21a-hydroxylase deficiency?

Answer 6

• cortisol replacement therapy for ACTH suppression
• fludricortisone for mineralocorticoid replacement
• reconstructive genital surgery

Question 7

what is the treatment for 11B-hydroxylase deficiency?

Answer 7

• cortisol replacement (hydrocortisone or dexamethasone) for ACTH suppression
• anti-HTN may be required for persistent HTN

Question 8

zollinger ellison syndrome is seen with which MEN?

Answer 8

MEN I

Question 9

mucosal neuromas are seen with which MEN?

Answer 9

MEN IIb