Endocrine disorders Flashcards
What drugs lead to osteopenia
- Corticosteroids
- anticonvulsants
- HIV drugs
- Alcohol
- blood thinners
Corticosteroid effects on bone (2) and endogenous source
- Osteoperosis
- Osteonecrosis (AVN)
Endogenous source- Cushings syndrome
Cushing syndrome: age, m/f, mc Cause
20-50 yoa
women>m
-Pituitary adenoma (ACTH secreting tumor)
Cushing syndrome si/s (4)
- rapid weight gain
- moon face
- thin skin, purple striae
- mental issues
Cushings syndrome major complications
skin inf
diabetes
hypertension
avn * (HAVE TO RULE THIS OUT W THESE PTS)
What is kummels disorder and what is it associated w
Gas containing compression fx
-due to corticosteroid induced avn
What are the 3 major forms of Hyperparathyroidism
Primary- increased PTH from gland itself
Secondary- renal disease (leading to calc loss)
Tertiary- latrogenic due to dialisis
What are the key imaging findings in hyperparathyroidism (4+1)
-Osteopenia
-Subperiosteal bone resorption
-subchondral resporption
-brown tumours
(rugger jersey spine)
What are the soft tissue findings of HPTH
renal calculi
Vascular calcifications
Where is subperiosteal bone resoption found
m/c in hands (radial surface)
Brown tumor characteristics
painless eccentric lytic lesion
Subchondral resporption common locations (3)
Distal clavicles
SI jt
Symphysis pubis
subligamentous resoption mc locations (3)
Trochanters
vert bodies
calcaneous (inf)
What is acromegaly and mc cause
overprod of GH
MC cause pituitary adenoma
Difference bw acromegaly + gigantism
Acromegaly- post skeletal maturity
Gigantisim- prior to skeletal maturity
