Endocrine and Diabetes

Question 1

HbA1c targets for diabetics?

Answer 1

<48mmol/mol
OR
<53mmol/mol if on hpoglycaemic associated drugs

Question 2

Drugs for managing BP in diabetes?

Answer 2

ACEi first line
UNLESS: pregnant or Afro-Caribbean
If pregnant - calcium channel blocker
if Afro-Caribbean - ACEi + (diuretic or CCB)

Question 3

Blood glucose management drugs?

Answer 3

1. Metformin (if no good, try drugs in 2)
2. Add either:
   a. DPP4i
   b. piaglitazone
   c. sulfonylurea
3. 1+a+c OR 1+b+c
4. Insulin
   OR
   Metformin and sulfonylurea and GLP1 mimetic

Question 4

Sulfonylureas?

Answer 4

Gliclazide, tolbutamide, glimepiride
Weight gain
Need some pancreatic function as augment insulin secretion

Question 5

DPP4 inhibitors?

Answer 5

Gliptins

Can aid weight loss

Question 6

Pioglitazone?

Answer 6

Thiazolidenidione

Contraindicated in heart failure and bladder cancer, uninvestigated haematuria