Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

UWorld Step 3 > Endocrine > Flashcards

Endocrine Flashcards

1
Q

Patients with thyroid nodules should be evaluated for what?

A

Malignancy (family history, radiation exposure in childhood, cervical LND), Compressive symptoms (hoarseness, difficulty swallowing), functional status

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the definitive diagnosis for tyroid cancer?

A

Fine needle aspiration (FNA) however the goal of this clinical assessment is to determine who requires this invasive procedure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the initial testing to evaluate thyroid nodule?

A

Serum TSH level, and thyroid ultrasound

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the suspicious ultrasound findings?

A

Internal vascularity, microcalcifications, hyperechoic, large size

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Patients with low TSH, what is the next test and clinical assessment?

A

Iodine 123 scintigraphy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the next step in a patient who has no cancer risk factors or suspicious ultrasound findings however has normal or elevated TSH?

A

FNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

When can CT scan of the neck be chosen for diagnosis?

A

Retrosternal goiter in patients with compressive symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the primary modality for initial staging of thyroid cancer?

A

Ultrasound of the neck and cervical lymph nodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Total thyroidectomy is recommended for which patients?

A

Four large papillary thyroid cancer’s, extra thyroid tumor extension, distant metastasis, history of head or neck radiation exposure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which patients can be managed with simple thyroid lobectomy?

A

Papillary cancer is less than 1 cm microcarcinoma with no lymph node involvement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

When is radioactive iodine used?

A

Adjunct therapy for thyroidectomy patience with race for metastasis such as does with very large tumors invasive tumors or lymph node involvement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Non-functioning pituitary adenoma most commonly arises from what type of cells?

A

Gonadotrophin secreting cells (gonadotrophs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How would the patient present physically and labs who has a nonfunctioning pituitary adenoma?

A

Suppressed LH and FSH, amenorrhea, blurred vision, dyspareunia, increased alpha subunits headaches, mass effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are alpha subunits?

A

Dysfunctional cells in most gonadotroph adenomas secrete primarily a common alpha subunit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the preferred therapy for most non-functional pituitary adenoma’s? What are the effects that can be expected after?

A

Transphenoidal surgery; Patients may experience rapid relief of associated neurologic symptoms end it may also regain normal gonadal function after resection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What can explain the mild increase in prolactin and nonfunctional pituitary adenoma’s?

A

If a large would be able to compress the pituitary stock and black normal hypothalamic inhibition of prolactin secretion, leading to mild increase in prolactin levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How can patients with pituitary adenomas be treated for their amenorrhea?

A

Estrogen and progesterone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is a growth hormone producing add a noma and how can you be treated?

A

Acromegaly. Octreotide hey somatostatin analog ask on somatostatin receptors in the pituitary to inhibit the release of growth hormone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Increased urinary cortisol level, nonsuppressible high dose of dexamethasone suppression test, and undetectable ACTH levels are suggestive of what?

A

Cushing’s syndrome secondary to an adrenal etiology

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the ideal imaging for adrenal glands?

A

CT scan and MRI have equal sensitivity and specificity for adrenal tumors however you CT scan for less cost for the more MRI as sometimes more useful for for the characterization of adrenal tumors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is inferior petrosal sinus sampling used for?

A

Differentiate between ACTH production, pituitary versus ectopic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is the Definition of failure to thrive?

A

Weight below 5th percentile or downtrending weight percentile’s crossing two percentiles 50th 25th 10th

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What are the causes of FTT?

A

Inadequate intake, inadequate calorie absorption (cystic fibrosis, celiac disease), increase calorie requirement (hyperthyroidism, congenital heart disease)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is the first step in patients with FTT?

A

Thorough history and physical examination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What is the most common etiology for FTT?
In adequate calorie intake secondary to psychosocial stressors
26
What are the example of psychosocial stressors that can cause in adequate caloric intake?
Poverty (lack of access to food) lack of knowledge of appropriate feeding techniques (excessive water to formula powder ratio), poor parental/child relationship (neglect, abuse)
27
What is the hormone that induces maternal insulin resistance? And when is it secreted during gestation?
Human placenta lactogen; second and third trimesters; insulin resistance and sure as they are sufficient supply of glucose for fetal development.
28
What patient are at risk for gestational diabetes mellitus GDM?
Inadequate pancreatic function
29
What are the complications that are associated with GDM?
Obstetric (preeclampsia) and Neonatal ( hypoglycemia polycythemia)
30
When a patient screamed at for GDM?
Patient with risk factors for undiagnosed pre-gestational type two diabetes obesity prior macrosomic and spent our screen as early as the initial prenatal visit. Patient without risk factors are screamed at 24 and 228 weeks gestation
31
What is the approach for screening GDM?
Two-step approach: glucose challenge test (GCT) then 3-hour glucose tolerance test (GTT)
32
What is the indication for second step for the two-step approach screening?
GCT: Blood glucose level greater or equal to 140 mg over deciliter is an indication for second step
33
How is GM diagnosed?
GTT: Fasting blood glucose levels measured one, two, three hours after 100g Glucose load; When two or more of GTT values are elevated
34
Why is hemoglobin A-1 C level a less sensitive screening test for diabetes and pregnant women?
Because it is a lower than normal in pregnant women do to physiologic increases in red blood cell mass and cell turnover
35
What should be monitored in patients with abnormal GTT?
Fasting less the 95. postprandial glucose levels At one hour less than 140 at two hours less than 120
36
What are the consequences for poor maternal glycemic control? What should be done to prevent this?
Fetal hyperglycemia and hyper-insulinemia, resulting in macrosomia; Severe maternal hyperglycemia can cause chronic uteroplacental insufficiency and fetal growth restriction; Insulin
37
How would a patient with thyroid Lymphoma present?
Chronic lymphocytic infiltration; Mild goiter over years, preexisting Hashimoto thyroiditis, mildly enlarged thyroid gland difficulty swallowing that rapidly worsens, swelling in front of neck growing rapidly recently, fever, night sweats and weight loss, positive Pemberton’s test
38
What is Pemberton’s test?
Consist of having a patient rates his arms over his head for up to 60 seconds, the presence of facial plethora or an engorgement of the neck veins is suggestive of thyroid obstruction symptoms
39
What is colloid goiter?
Cause for thyroid enlargement in adolescent girls who have normal thyroid function test and negative anti-thyroid antibodies
40
How may patients with Familial Hypocalciuric Hypercalcemia (FHH) present?
Asymptomatic hypercalcemia, high normal PTH, low urinary calcium excretion, mildly serum calcium
41
What are the effects of mutated calcium sensor receptor in FHH?
Defective calcium sensing receptor causes decreased sensitivity to calcium and higher calcium concentration’s are required to suppress PTH release. Concurrently defective CaSRcauses increased reabsorption of calcium in renal tubule’s
42
What can untreated primary hyperparathyroidism lead to?
Osteoporosis, nephrolithiasis, chronic kidney disease
43
FHH and PHPT can’t be differentiated by what?
Urinary calcium excretion. FHH is associated with lower urinary calcium levels (less than 100mg/24hrs), PHPT causes increased reabsorption of calcium, net excretion is increased due to accelerated bone turnover (Greater than 300)
44
Diagnosis of FHH is confirmed by what?
Testing for CaSR mutations
45
How would a patient with Nelsons syndrome present? Labs and imaging?
Tanned patient with bitemporal hemianopsia, history significant for bilateral adrenalectomy for Cushing’s disease; Extremely high ACTH and pituitary adenoma with suprasellar extension on MRI
46
How does craniopharyngioma present?
Occur in children can also occur in adults. Present with visual field defect’s and hypopituitarism. Diabetes insipidus is more common compared to Mass Effect
47
Describe the relationship between bitemporal hemianopsia and brain tumors?
Brain tumors usually do not present with bitemporal hemi of naps here except for parasellar and intrasellar meningiomas
48
How would a patient with DKA presents?
Abdominal discomfort, nausea/vomiting, hyperglycemia with metabolic acidosis and a positive ketones
49
How can DKA be precipitated?
Not taking the appropriate dosage of insulin along with some type of stressed like concurrent illness
50
What is the initial management for DKA? How should a risk of hypokalemia be avoided?
Aggressive IV fluid support with normal Saline and continuous insulin. Potassium should be monitored and added to IV fluids if Potassium levels are less than 5.2
51
What indicates on going keto acidosis? For how long should I V insulin be continued for?
Anion gap with low bicarbonate. IV insulin should be given until anion gap is normalized
52
During the treatment in DKA with IV insulin what is a good indicator of possible hypoglycemia as a complication? What should be done to prevent hypoglycemia?
Persistently elevated anion gap with blood glucose less than 200; Insulin dose should be half the end of patients to receive IV fluids with 5% dextrose
53
How was the sodium concentration of IV fluids determine?
By finding the corrected serum sodium. If less than 135 should use normal Saline, If greater than 135 should use half normal saline
54
How do you calculate corrected serum sodium?
[(Measures sodium +0.016) times (glucose -100)]
55
What should be done for a patient who had DKA with insulin infusion and the ion gap has normalized along with glucose less than 200?
Subcutaneous insulin should be given now and insulin infusion should be stopped in two hours
56
What is the criteria for transition from intravenous insulin to subcutaneous insulin?
Glucose less than 200 able to eat and 2/3: serum anion gap less than 12, bicarbonate less than 15, Venus pH greater than 7.3
57
What is the management for DKA and HHS as a pertains to IV fluids?
Hi Flo normal Saline is initially recommended | Add dextrose 5% when serum glucose is less than or equal to 200
58
What is the management for DKA and HHS as a pertains to Insulin?
Initial continuous IV insulin fusion. Switched to SQ basal bolus if reach criteria. Overlap SQ and IV insulin by 1-2 hours
59
What is the management for DKA and HHS as a pertains to Potassium?
Add IV potassium of serum K+ is less than or equal to 5.2 | Hold insulin for serum K+ less than 3.3
60
Explain what consists in a patient who is converted to SQ insulin?
Combination of long acting insulin basal insulin (glargine, detemir), rapid acting insulin bolus insulin (regular lispro aspart) with meals and correction insulin for hyperglycemia on sliding scale
61
What is the management for DKA and HHS as a pertains to Bicarconate?
Consider for patients with severe acidosis (pH less than 6.9) Which can result in decreased cardiac contractility and systemic vasodilation
62
What is the management for DKA and HHS as a pertains to phosphate?
Consider for Serum phosphate less than 1mg/dL, cardiac dysfunction or respiratory depression. Monitor serum calcium frequently
63
When a patient with diabetes given high intensity Staten that supposed to moderate intensity Statin?
ten-year ASCVD risk equal to or greater than 7.5 will result in high intensity
64
What are the guidelines for Statin therapy?
ASCVD, LDL greater than 190, diabetes above age of 40, 10yr risk getter than 7.5
65
What is diabetic retinopathy screening indicated for type one and type two patients? This method mimics what other screening test for diabetic patient?
Type 1 beginning 3 to 5 years after original diagnosis, type 2 at the time of diagnosis; Same method is used for nephropathy
66
What is the preferred medication for treating hypertension in patients who are diabetic? What other instance with diabetes should this medication be used?
ACEi, Diabetes with Nephropathy
67
What is the difference between physiologic gynecomastia and pseudo gynecomastia? How should it to be differentiated?
Pseudogynecomastia are deposits of fat in overweight or obese boys. It’s able to be differentiated by the presence of palpable mass
68
What are the major causes for primary ovarian insufficiency (POI)? What is the treatment?
Fragile X syndrome, turner syndrome, autoimmune oophoritis, anticancer drugs pelvic radiation, galactosemia; Estrogen therapy with progestin if intact uterus
69
What is a common gynecological complication associated with cancer treatment (chemotherapy and radiation therapy)?
POI
70
What therapy can be used in postmenopausal osteoporosis however it hasn’t been proven to alleviate rapidly loss of bone mass in POI patients?
Bisphosphonates and calcitonin as second line agent
71
What is Raloxifene why can it be use for postmenopausal osteoporosis? What are some of the drawbacks?
Selective estrogen modulator; Stimulates as your receptors on bone cells to improve density however is antagonistic on other estrogen response of sales and therefore would worsen Hypoestrogen symptoms

UWorld Step 3 (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions