Endocrine Flashcards

1
Q
A
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2
Q

What are the dual functions of testes and ovaries?

A

Both produce gametes (sperm in males, oocytes in females) and secrete reproductive hormones.

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3
Q

What is the role of reproductive hormones?

A

Essential for the development of sexual characteristics and regulation of reproductive functions.

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4
Q

What hormone is secreted by the testes?

A

Testosterone

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5
Q

What are the functions of testosterone?

A
  • Regulates sperm production
  • Develops and maintains male reproductive organs
  • Influences secondary sexual characteristics like facial hair, deep voice, and muscle growth
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6
Q

What hormones are secreted by the ovaries?

A

Estrogen and progesterone

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7
Q

What are the functions of estrogen and progesterone?

A
  • Control the female reproductive cycle with the help of FSH and LH
  • Prepare the mammary glands for lactation
  • Support and maintain pregnancy
  • Develop and maintain female reproductive organs and secondary sexual characteristics
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8
Q

What is the role of LH (Luteinizing Hormone) and FSH (Follicle-stimulating Hormone) in males and females?

A

Stimulate hormone secretion in the testes and ovaries

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9
Q

How are LH and FSH regulated?

A

Controlled by a releasing hormone from the hypothalamus and regulated through a negative-feedback mechanism.

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10
Q

Where is the thymus gland located?

A

A bilobed lymphoid organ in the upper chest, behind the breastbone and between the lungs.

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11
Q

What is the primary function of the thymus gland?

A

Produces hormones like thymosin needed for the development and maturation of T-lymphocytes (T-cells).

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12
Q

What happens to the thymus gland after puberty?

A

It gradually decreases in size, a process known as involution.

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13
Q

What is the first stage of thymocyte maturation?

A

Subcapsular Region

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14
Q

What are the key markers in the DN1 stage?

A

High CD44, No CD25

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15
Q

What occurs during the DN3 stage of thymocyte maturation?

A

Completion of TCR beta chain rearrangement; expression of pre-TCR complex.

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16
Q

What is positive selection in T-cell development?

A

T cells interact with thymic epithelial cells to learn MHC restriction.

17
Q

What is negative selection in T-cell development?

A

Elimination of T cells with high-affinity interactions with self-peptides to prevent autoimmunity.

18
Q

What hormones are present in the subcapsular region and cortex of the thymus?

A
  • Thymosin
  • Thymosin Alpha 1
  • Thymulin
  • Thymic Humoral Factor (THF)
19
Q

What condition is characterized by thymic hyperplasia?

A

Swollen and inflamed thymus, often occurring in autoimmune disorders.

20
Q

What is myasthenia gravis (MG)?

A

A condition where muscles weaken and tire, often associated with impaired thymus function.

21
Q

What is DiGeorge syndrome?

A

A condition causing T-cell deficiency due to an absent or underdeveloped thymus gland at birth.

22
Q

What are the two types of thyroid hormones?

A
  • Thyroxine (T4)
  • Triiodothyronine (T3)
23
Q

What is the main form of thyroid hormone produced by the thyroid gland?

A

Thyroxine (T4)

24
Q

What condition results from an underactive thyroid?

A

Hypothyroidism

25
Q

What is myxedema?

A

A condition characterized by a lowered rate of metabolism, sluggishness, and fluid accumulation.

26
Q

What is Cushing’s syndrome?

A

A condition caused by too much secretion from the adrenal cortex.

27
Q

Where are the adrenal glands located?

A

On top of each kidney.

28
Q

What hormones are released by the adrenal medulla?

A
  • Epinephrine
  • Norepinephrine
29
Q

What type of hormones does the adrenal cortex secrete?

A

Mineralocorticoid hormones, glucocorticoid hormones, and adrenal sex hormones.

30
Q

What is Addison’s disease?

A

A condition where the adrenal cortex fails to produce enough hormones.