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Pharm Endocrine Meds > Endocrine > Flashcards

Endocrine Flashcards

1
Q

Classes of Endocrine Drugs

A

Pituitary
Thyroid & Antithyroid
Antidiabetic
Adrenal Drugs

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2
Q

What Controls the Pituitary Gland

A

Hypothalmus

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3
Q

Parts of the Pituitary Gland

A

Anterior (Adenohyphphysis)
Posterior (Neurohypophysis)
Each lobe secrets different hormones

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4
Q

What are the anterior pituitary hormones?

A

Corticotropin & Thyrotropin

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5
Q

General info on Corticotropin

A 
Adrenocorticotropic hormone (ACTH)
Acts on adrenal gland to promote synthesis & release of adrenocortical hormones
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6
Q

General info on Throtropin

A

Thyroid-stimulating hormone (TSH)

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7
Q

Anterior Pituitary Hormones

A 
Growth Hormone (GH)
Stimulates growth in almost all tissues and organs (Skeletal/muscle)
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8
Q

A deficiency of Growth Hormone results in

A

Pediatric Short Stature- retarded growth equal in all parts of body

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9
Q

An Excess of Growth Hormone results in

A

Gigantism- Pediatric, excessive growth before epiphyseal closure
Acromegaly- Adult, increased bone growth of face, hands, feet

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10
Q

Growth Hormone Prototype Drug

A

Somatropin (Humatrope, Nutropin)

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11
Q

Somatropin works by

A

-Stimulates Tissue building processes
*Increases size & number of muscle cells
*Increases size of internal organs
(Not brain or eyes)
-Stimulates Bone growth in length
-Releases more glucose

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12
Q

Indication for Somatropin

A

Pediatric Short Stature

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13
Q

Somatropin is given in the following forms

A

IM or Subcutaneous

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14
Q

Adverse effects of Somatropin

A

Hyperglycemia
Hypothyroidism
Antibody development

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15
Q

Somatropin Interactions

A

Glucocorticoids

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16
Q

Somatropin expected Therapeutic Response

A

Increased growth

Stop treatment prior to epiphyseal plate closure

17
Q

Nursing implications for growth hormones

A 
Document growth (height, weight), motor skills
Monitor blood glucose, thyroid function, gallbladder function
18
Q

Posterior Pituitary Hormones are

A

Oxytocin & Antidiuretic hormone (ADH)

19
Q

Functions of Oxytocin

A

Stimulates contraction of uterine smooth muscle
Stimulates ejection of milk
Plays a role in mother’s attachment to infant

20
Q

Functions of Antidiuretic hormone (ADH)

A

Promotes renal conservation of water
Acts on collecting ducts of kidney to increase their permeability to water  Increased water reabsorption
Stimulates contraction of vascular and GI tract smooth muscle
Vasoconstriction results
Stimulated by high osmolality, hypotension, reduced plasma volume

21
Q

ADH drug effects

A

Mimic actions of antidiuretic hormone (ADH)
Increase water resorption & concentrate urine
Reduce water excretion up to 90%

22
Q

ADH Prototype Drugs

A

Vasopressin, Desmopressin (DDAVP)

23
Q

Vasopressin general info and uses

A 
Potent vasoconstrictor (higher doses)
Used for hypotensive emergencies (septic shock)
Treatment of GI bleeds(vasoconstruction)
24
Q

Desmopressin general info

A

Can be given IV, SC, PO, Intranasal
Really slows down urine
Less vasoconstriction

25
Q

Desmopressin Indications

A
  • Nocturnal enuresis
  • Diabetes Insipidus
  • Deficiency of ADH characterized by excessive thirst (polydipsia) and excretion of large volumes of dilute urine
  • Caused by inherited factors, head trauma, cancer, neurosurgery
26
Q

Vasopressin adverse effects

A
  • Excessive vasoconstriction causing Angina and possibly MI

- Headache

27
Q

Desmopressin adverse effects

A

Water intoxication

-Drowsiness, listlessness, headache

28
Q

Vasopressin, Desmopressin nursing implications

A

Monitor:

  • Vital Signs (especially BP)
  • Weight
  • Intake and Output, especially urine output
  • Urine Specific Gravity(concentration) water is 1-pure the higher the concentration, the #
29
Q

Therapeutic response for Vasopressin

A

Increased blood pressure

30
Q

Therapeutic response for Desmopressin

A

Decreased thirst
Decreased urinary output
Decreased bleeding

Pharm Endocrine Meds (3 decks)

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