Endocrine Flashcards

1
Q

Which insulin has a black box warning? What’s the warning

A

Rapid-acting insulin has a black box warning of bronchospasms

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2
Q

Which insulin can be mixed with NPH

A

Rapid acting and Short acting (Regular)

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3
Q

What is rapid-acting insulins onset, peak, and duration

A

onset: 15-30mins
peak: 1-3
duration: 3-5

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4
Q

When should you administer rapid-acting insulin

A

15 mins before a meal or DIRECTLY after meals

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5
Q

What is the only insulin permitted to be given IV?

A

Short-acting insluin

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6
Q

What is short-acting insulins onset, peak, duration

A

onset: 30 mins
peak: 3 hrs
duration: 8hrs

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7
Q

When should you administer short-acting insulin?

A

30 minutes BEFORE meals

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8
Q

Intermediate or NPH insulins onset, peak, and duration?

A

onset: 3-4hrs
peak: 6 hrs
duration: up to 24hrs

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9
Q

When should you administer NPH or intermediate insulin?

A

once or twice DAILY

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10
Q

What insulin has no peak?

A

Long acting

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11
Q

Onset and duration for long-acting insulin?

A

onset: 3-4hrs
duration - 24 hrs or longers

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12
Q

How often should long-acting insulin be administered?

A

ONE TIME daily

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13
Q

A patient who is having a hypoglycemic episode is likely to receive?

A

Glucagon

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14
Q

Purpose of glucagon?

A

Increases blood glucose during a hypoglycemic episode

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15
Q

adverse side effects of glucagon

A

hypo/hyperglycemia

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16
Q

What is sulfonylurea prototype?

A

Glipizid

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17
Q

MOA of glipizide

A

stimulates insulin secretion from pancreatic islet tissue

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18
Q

What kind of diabetes is glipizide contraindicated?

A

Diabetic ketoacidosis

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19
Q

Adverse side effects of glipizide

A

Can affect RBC and WBC causing anemias and leukopenia also erythema multiforme (red spots)

20
Q

A patient on glipizide should avoid?

A

Alcohol and NSAIDS

21
Q

Prototype of biguanide

A

Metformin

22
Q

Which type 2 diabetic medication can produce hypoglycemia?

A

Glipizide, and Sitagliptin

23
Q

MOA of metformin

A

decreases hepatic glucose production and decrease intestinal glucose absoprtion

24
Q

What is the best time for patients to take metformin and why

A

bed time because it can cause GI distres

25
Q

Which type 2 diabetes medication increases insulin release while decreasing glucagon

A

Sitagliptin

26
Q

Adverse side effects of sitagliptin

A

upper respiratory infections, pancreatitis, severe arthralgia

27
Q

Thyroid replacement prototype?

A

Levothyroxine (Synthroid)

28
Q

How would you instruct a patient to take levothyroxine?

A

Full glass of water on empty stomach before breakfast

29
Q

What thyroid medication can worsen glycemic control in diabetics?

A

Levothyroxine

30
Q

Adverse side effect of levothyroixine ?

A

HYPERthyriod side effects
diarrhea , sweating, heat intolerance

31
Q

A patient with hypothyroidism would take ?

A

Levothyroxine or Synthroid

32
Q

A patient with hyperthyroidism would take?

A

Propythiourcali

33
Q

what does propylthiouracil do?

A

inhibits synthesis of thyroid hormone

34
Q

Adverse side effects of propylthiouracil

A

Liver injury, fetal harm, jaundice, agranulocytosis

35
Q

Antithyriod protoype?

A

Propythiourcali

36
Q

A patient with osteoporosis is likely to be prescribed?

A

Calcitonin

37
Q

Route of calcitonin?

A

Intranasally

38
Q

What kind of diet should a patient taking calcitonin have?

A

High in calcium and vitamin D

39
Q

How should you store calcitonin

A

Refrigerate after opening

40
Q

A patient with adrenal insufficiency would be likely to take?

A

Corticosteroids

41
Q

Long-term use of corticosteroids can cause

A

Psychosis , CV disease, and osteoporosis

42
Q

Stopping corticosteroids aburptly can cause?

A

Adrenal crisis

43
Q

MOA of mineralocotricoids

A

Electrolyte and water balance

44
Q

When giving glucocorticoids what should you monitor?

A

Glucose

45
Q

Adverse side effects of corticosteroids

A

Thing fragile skin, Cushing’s, insomnia