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Peds > Endocrine > Flashcards

Endocrine Flashcards

1
Q

What is hypopituitarism?
p. 861-866

A

Deficient secretion of pituitary hormones which lead to retarded growth, gonadotropin deficiencies, thyroid and adrenal deficiencies depending on which hormones are deficient.

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2
Q

What is congenital hypothyroidism?
p. 869-870

A

Decrease in T3 and T4 which slows the metabolic rate. Usually an
embryonic autosomal recessive defect in the thyroid gland.

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3
Q

What is congenital adrenal hyperplasia?
p. 873-874

A

Family of genetic conditions affecting the adrenal glands that interferes with normal growth and development including normal development of the genitals due to decreased or absent cortisol synthesis

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4
Q

What is Turner syndrome?
p. 892

A

Chromosomal disorders interfering with normal growth processes; absence of X chromosomes: 45 XO karyotype

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5
Q

What is Klinefelter Syndrome?
p. 893

A

Chromosomal disorders interfering with normal growth processes;
excess of X chromosomes: 47 XXY karyotype

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6
Q

S/s of hypopituitarism

A
  • Short stature
  • Delayed bone age
  • Infertility
  • Intolerance to cold
  • Fatigue
  • Loss of hair
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7
Q

S/s of congenital hypothyroidism

A
  • Pallor
  • Decreased temperature
  • Hypoactivity (sluggish)
  • Decreased muscle tone
  • and reflexes
  • Large tongue
  • Bradycardia
  • Constipation
  • Feeding difficulties
  • Dry and cracked skin
  • Edema at eyelids
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8
Q

S/s of congentital adrenal hyperplasia

A
  • Salt wasting - which can be life threatening (shock)
  • Hyponatremia
  • Hyperkalemia
  • Hypoglycemia
  • Ambiguous genitalia
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9
Q

S/s of Turner Syndrome

A
  • Edema to hands and feet
  • Low posterior hairline/webbed neck
  • Low set ears
  • Short stature
  • Delayed pubertal development
  • Amenorrhea
  • Normal growth until 3 years, then
  • no growth spurts
  • Infertile
  • Kidney, thyroid, heart and other
  • problems
  • Learning difficulties
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10
Q

S/s of Klinefelter Syndrome

A
  • Not detected until puberty
  • Varying degrees of mental
  • impairment
  • Severity of intellectual disability
  • increases with the additional #
  • of X chromosomes
  • Tall
  • Hypogenitalism
  • Gynecomastia
  • Sterile
  • Poor social interactions
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11
Q

Tx of hypopituitarism

A
  • Replacement of Growth hormone every day until growth plates close (side effects: increase in blood glucose and gynecomastia)
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12
Q

Tx of congenital hypothyroidism

A

Thyroid hormone replacement

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13
Q

Tx of congenital adrenal hyperplasia

A

Steroid (hydrocortisone +/- fludrocortisone) replacement, Salt replacement

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14
Q

Tx of Turner Syndrome

A

Growth hormone Estrogen (beginning around 12 -13 years)

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15
Q

Tx of Klinefelter Syndrome

A

Testosterone replacement beginning at puberty

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16
Q

Nursing Implications of hypopituitarism

A
  • Family teaching and support
  • Child will reach normal adult height, but more slowly than others (takes 3-6 months to see changes)
  • Wear a medical identification bracelet
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17
Q

Nursing Implications of Congenital Hypothyroidism

A
  • Give med on empty stomach
  • 30 minutes before food
  • Separate from iron and calcium supplements by 4 hours
  • Testing is done at newborn screening
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18
Q

Nursing Implications of Congenital Adrenal Hyperplasia

A
  • Increased steroid doses during times of illness, injury and stress.
  • Foster bonding between parent and child
  • Educate parents about reconstructive surgery options
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19
Q

Nursing Implications of Turner Syndrome

A
  • Educate about learning abilities and fertility
  • In vitro fertilization can be effective
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20
Q

Nursing Implications of Klinefelter Syndrome

A
  • Therapies (OT, PT, speech)
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21
Q

Causes of hypoglycemia

A
  • Insulin dose too high for food eaten
  • Insulin injection into muscle
  • Too much exercise for insulin dose
  • Too long between snacks/meals
  • Too few carbohydrates eaten
  • illness, stress
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22
Q

Clinical manifestations of hypoglycemia

A
  • Rapid onset
  • irritability, nervousness, tremors, shaky feeling, difficulty concentration or behavior change, confusion, repeating something over and over
  • unconsciousness, seizure, shallow breathing, tachycardia
  • pallor, sweating
  • moist mucous membranes, hunger,
  • headache, dizziness, blurred vision, double vision, photophobia
  • Numb lips or mouth
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23
Q

Clinical therapy of hypoglycemia

A
  • If conscious, give 15g of carbohydrate
  • Wait 15 minutes and recheck blood glucose
  • Give another 15g of carbohydrates if 70mg/dL or below
  • Recheck the blood glucose in 15 mins

If unconscious, give glucagon by injection

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24
Q

Causes of hyperglycemia

A
  • Insulin dose too low for food eaten
  • illness or injury, stress
  • too many carbohydrates eaten
  • Meals/snacks too close together
  • Insulin injected just under skin or into hypertrophied areas
  • Decreased activity
25
Q

Clinical manifestations of hyperglycemia

A
  • Gradual onset
  • Lethargy, sleepiness, slowed responses, or confusion
  • Deep, rapid breathing
  • flushed skin or dry skin
  • dry mucous membranes, thirst, hunger, dehydration
  • Weakness, fatigue
  • Headache, abdominal pain, nausea, vomiting
  • Blurred vision
  • shock
26
Q

Clinical Therapy of hyperglycemia

A

Give additional insulin at usual injection time
Give correction scale insulin doses for specific blood glucose levels when ill or injured
give extra injections if hyperglycemia and moderate to large ketones
increase fluids

27
Q

Rapid Acting Insulin

A
  • Humalog (Lispro),
  • Glulisine, (Apidra),
  • Aspart;
  • Afrezza

Onset: 15-30 min (Afrezza <15min)

Peak: 30-90 min (Afrezza 10-20min)

Duration: <5 hours (Afrezza 2-3 hours)

28
Q

Short Acting Insulin

A

Regular, Novolin

Onset: 30-60 min
Peak: 2-5 hours
Duration: 4-12 hours

29
Q

Intermediate Insulin

A

NPH

Onset: 1-2 hours
Peak: 6-10 hours
Duration: 14-24 hours

30
Q

Long-acting insulin

A

Glargine (Lantus, Toujeo) 3-6 hours/minimal/24 hours
Detemir (Levemir), 3-4 hours/3-9 hours/24 hours
Degludec (Tresiba) 1hour/9 hours/42 hours

31
Q

Insulin condsiderations for puberty

A

Insulin resistance and fluctuations in glucose levels

  • Insulin doses may need to increase
32
Q

Insulin considerations for Adolescent Psychosocial development/Noncompliance

A

(impulsiveness, mood swings, struggle for independence)

  • Care contracts, increased responsibilities, screen for depression, test glucose before driving, sex education and protection
33
Q

Insulin considerations: Developmental Approaches – Toddlers

A
  • Introduce the parents to other families with children with diabetes or find a support group.
  • Offer toddler choices of snacks and injection sites
  • Offer finger foods
34
Q

Insulin considerations: Developmental Approaches – Pre-School

A
  • Let child help choose foods, let child wipe skin for shots and glucose checks
  • Needle play with dolls (with supervision)
  • Play games to teach about hypoglycemia
35
Q

Insulin considerations: Developmental Approaches – Elementary

A
  • Play board and computer games about diabetes.
  • Attend diabetes camps.
  • Can follow a diet and help with management with close supervision.
  • Help with meal planning and preparation.
  • Can count carbohydrates.
  • Can administer or begin assisting with administration of insulin (drawing up and injecting); performing fingersticks with supervision.
  • **Does not fully comprehend how doing something now affects long-term outcomes (good diabetes control prevents complications later) **
  • If the child has electronic devices (phone, tablet, etc.), can download and use diabetes and carbohydrate monitoring apps
36
Q

Insulin considerations: Developmental Approaches – Young Adolescents

A
  • Support groups, negotiate plans to allow increasing responsibility for management with supervision
  • If the child has electronic devices; download diabetes management apps
  • Impulsiveness, mood swings, struggle for independence and body image are key influencing factors and can lead to noncompliance issues: care contracts can be used to foster accountability and increase compliance
  • Screen for depression, test glucose before driving, sex education and protection
37
Q

Insulin considerations: Developmental Approaches – Older Adolescents

A

Should begin to be independent with care by about 16 years. May still need help with insulin dosing decisions.

38
Q

Phenylkentonuria (PKU)
p. 893

A
  • Autosomal recessive disorder of metabolism that affects the body’s ability to use protein.
  • Must be detected early (is screened in newborn screenings), because if untreated it can lead to brain damage and developmental delay; autism spectrum-like behaviors
  • Diet low in phenylalanine; proteins and aspartame (artificial sweeteners)
    ** Fruits and vegetables are good, Lofenalac formula, carbs
    See the “Target” diet below for best options of acceptable foods
39
Q

Precocious Puberty
p. 868-869

A

Precocious puberty is when a child’s body begins puberty too soon, and is considered to begin before age 8 in girls and age 9 in boys. Administer hormone to stop puberty until they reach appropriate puberty time.

40
Q

Developmental effects of endocrine disorders

A

Hypothyroidism: if
undertreated leads to delayed
growth and intellectual
disability (treat with thyroid
replacement)
Turner Syndrome: learning
disabilities
Klinefelter Syndrome: delayed
milestones, low verbal IQ

41
Q

Effects of endocrine disorders on heart and lungs.

A

Hypothyroidism: bradycardia
CAH: dehydration/shock; hyponatremia
(treat with glucocorticoids,
mineralocorticoids, salt)
Turner Syndrome: congenital heart
defects

42
Q

Effects of endocrine disorders on the reproductive system.

A

Hypothyroidism: altered puberty
CAH: virilization; ambiguous genitalia
(females); premature sexual development
Turner Syndrome: infertility; delayed
puberty
Klinefelter Syndrome: infertility; delayed
puberty; decreased hair growth; small
testes; gynecomastia (treat with
testosterone)

43
Q

Effects of endocrine disorders on the skin.

A

Hypothyroidism: dry, cool skin;
sensitivity to cold

44
Q

Effects of endocrine disorders - psychosocial

A

Turner Syndrome: Body image, self-
esteem
Klinefleter Syndrome: school difficulty;
difficult socialization

45
Q

Effects of endocrine disorders - head and neck

A

Hypothyroidism: thick tongue; thin
hair
Turner Syndrome: webbed neck;
low hairline; small jaw; low set ears;
hearing loss

46
Q

Effects of endocrine disorders - GI/GU

A

Hypothyroidism: constipation
Turner Syndrome: kidney
abnormalities

47
Q

Effects of endocrine disorders - musculoskeletal

A

Hypopituitarism: short stature, growth
stops/slows at 1 year (treat with growth
hormone); decreased bone ossification; risk for
slipped capital femoral epiphysis (evaluate for
hip and knee pain and limp)
Hypothyroidism: delayed bone age; poor
muscle tone
CAH: early closure of epiphyseal plate; short
adult stature
Turner Syndrome: short stature and features
(treat with growth hormone); osteoporosis
(treat with estrogen and progesterone)
Klinefelter Syndrome: tall stature

48
Q

describe the patho of different endocrine disorders

A
  1. Hypothyroidism (congenital): spontaneous gene mutation
  2. Turner Syndrome: missing X chromosome
  3. Klinefelter Syndrome: extra X chromosome
  4. Congenital Adrenal Hyperplasia: autosomal recessive
  5. PKU: autosomal recessive
  6. Diabetes Mellitus: genetic predisposition; runs in families (no
    direct heredity)
49
Q

Anterior and Posterior pituitary hormones

A

FLAT PeG

These are follicle stimulating hormone (FSH), luteinizing hormone (LH), adrenocorticotropic hormone (ACTH), thyroid-stimulating hormone (TSH), prolactin, endorphins, and growth hormone (GH)

50
Q

What do the hormones of the pituitary gland control/affect

A

FSH - testes of male, ovaries of female (inhibin, testosterone, progesterone, estrogen) kleinfelter
LH - testes of male, ovaries of female (inhibin, testosterone, progesterone, estrogen) kleinfelter
ACTH - adrenal glands (epi, norepi) CAH
TSH - thyroid gland, thyroid hormones (TS3, TS4) hypothyroidism
PRL - mammary glands
GH - liver, bone, muscle tissues hypopituitarism

51
Q

What gland control metabolism (primarily)?

A

Thyroid

52
Q

A Pavlik harness has to be worn how long (hours/day)?

A

23-24 hrs/day
8-12 weeks

53
Q

What gland primarily affects growth?

A

pituitary gland

54
Q

What is associated with the 45 XO karyotype?

A

Turner Syndrome

55
Q

What is the primary method for reducing swelling while wearing a cast?

A

elevation

56
Q

What type of diet is appropriate for a child with PKU

A

low protein, fruits & veggies

57
Q

What is the tx for osteomyelitis?

A

long-term abx

58
Q

Most serious complication for CAH?

A

shock

59
Q

Tx for JIA?

A

anti inflmmatories
DMARDs (methotrexate)

Peds (13 decks)

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