Endo Meds

Question 1

MOA of sulfonylureas

Answer 1

stimulate pancreas to release more insulin

Question 2

Glyburide, Glipizide, Glimepiride are of which medication class?

Answer 2

sulfonylureas -“G” group

Question 3

Lactic acidosis is a potential side effect of which oral antidiabetic med?

Answer 3

Metformin

Question 4

MOA of alpha-glucosidase inhibitors

Answer 4

decrease glucose absorption in gut (bind to disaccharidases more readily than sucrose, so less glucose is absorbed)

Question 5

Arcarbose & Miglitol are of what class of medications?

Answer 5

alpha-glucosidase inhibitors

Question 6

MOA of thiazolidinediones

Answer 6

decrease gluconeogenesis

Question 7

Rosiglitazone (Avandia) & Pioglitazone (Actos) are of which class of meds?

Answer 7

thiazolidinediones “glitazones”

Question 8

SE of Rosiglitazone (Avandia)?

Answer 8

CHF

Question 9

MOA of Repaglinide (prandin) & Nateglinide (starlix)

Answer 9

rapidly absorbed from intestine & mimics effects of rapid acting insulin

Question 10

MOA of Exenatide (Byetta)

Answer 10

*injectable -mimics incretins (signals pancreas to increase insulin secretion, & liver to stop producing glucagon)

Question 11

SE of Exenatide (Byetta)

Answer 11

significant N/V/D

Question 12

Sitagliptan (Januvia) is of what medication class?

Answer 12

DD-4 inhibitor

Question 13

MOA of Sitagliptan (Januvia)

Answer 13

prevents incretins from being broken down–> inc insulin from pancreas & dec glucagon production by liver

Question 14

Pramlintide (symlin) MOA

Answer 14

**injectable, *resembles human amylin -slows absorption of glucose & inhibits action glucagons

Question 15

Beneficial SE of Pramlintide (symlin)

Answer 15

promotes weight loss