End of Lecture 30

Question 1

GPCR receptors are bound by

Answer 1

Acetylcholine

Question 2

Acetylcholinesterase terminates …… by inactivating acetylcholine

Answer 2

Neurotransmission

Question 3

Imatinib is an example of a ….

Answer 3

An example of a tumour cell enzyme drug is

Question 4

Aspirin is an inhibitor of

Answer 4

Cyclo - oxygenase

Reduce the capacity of cells to release protaglandins = less inflammation.

Question 5

Re; Enzyme drug targets

There are features of complimentality between the ______ protein and the ____. Usually in a “pocket”

Answer 5

Re; Enzyme drug targets

There are features of complimentality between the target protein and the drug. Usually in a “pocket”

Question 6

Dimerising involves ___phosphorylation

Answer 6

Dimerising involves autophosphorylation

Question 7

True or false

Nuclear hormone recptors can only act on targets in the nucleus

Answer 7

False.

also tagrets in the cytosol.

Question 8

true or False:

Gluco-cortiocoid can be in the cytoplasm or the nucleus

Answer 8

True.

Glucocortiocoid can be in the cytoplasm or the nucleus

Question 9

Noradrenaline acts on ..

This can be interrrupted by disturbing the ..

Answer 9

Adrenoceptors

…. reuptake of noradrenaline

Question 10

Insulin is a ____ feedback system

Answer 10

Insulin is a negative feedback system

Question 11

When cortisol levels are high, it negatively feeds back to the ________and less _________________hormone is released. That means the Adrenal glands is not stimulated and does not continue to release Cortisol

Answer 11

When cortisol levels are high, it negatively feeds back to the Pituitary and less adrenocorticotrophic hormone is released. That means the Adrenal glands is not stimulated and does not continue to release Cortisol