encapsulated bacterial pathogens

Question 1

h flu

Answer 1

small
g-
bacillus/ coccobacillus

Question 2

h flu can be cultured on ____ agar with ______

Answer 2

chocolate

NAD, heme

Question 3

encapsulated h flu

Answer 3

• positive quellung rxn –> used to visualize on scope
• serotype b= most virulent –> vaccine
• serotype a= most predominant

**6 serotypes a-f

Question 4

unencapsulated h flu

Answer 4

uri’s

Question 5

what are the virulence factors of h flu (3)

Answer 5

1) polysaccharide capsule
2) endotoxin (LPS)
3) IgA protease –> can colonize meninges –> meningitis

Question 6

h flu transmission

Answer 6

aerosol droplets

• immunosuppressed, asplenic
• children after maternal ab declined

Question 7

treatment of h flu

Answer 7

40% resistance to ampicillin
3rd gen ceph used for meningitis
chloramphenicol even though its pretty toxic

Question 8

Hib vaccine

Answer 8

capsular polysaccharide from serotype B conjugated to diptheria toxin

Question 9

neisseria meningitidis

Answer 9

g- “coffee bean”

ferments glucose and maltose

Question 10

vaccine for n meningitidis?

Answer 10

to the capsule –> for A and C BUT NOT B

Question 11

virulence factors of n meningitidis?

Answer 11

polysach capsule
9 serotypes –> A, B, C responsible for most diseases
IgA protease
lipooligosachharide –> induces sepsis

Question 12

sx of meningitis from n mening.

Answer 12

suddent onset fever
n/v
ha
ams
myalgias
petechial rash

Question 13

waterhouse friderichsen syndrome

Answer 13

primary adrenal insufficiency due to adrenal hem assoc with septicemia second to leaky capillaries in meningitis

Question 14

what do you use for proph for close contacts of meningitis

Answer 14

rifampin

Question 15

strep pneumo

Answer 15

just watch sketchy