Emultions

Question 1

Emultions

Answer 1

Small immiscible globules dispersed phase

Throughout avichle in witch it is not miscible

Question 2

Types of despersions

Answer 2

Oil in water:dispersion where oil in internal and water is external
Water in oil:a phase where water in internal and oil is external

Question 3

Emulsyfing agents

Answer 3

Hydrophilic with lipophilic parts provide a interface protective barrier and stabilize emulsion be reducing surface tenstion

Question 4

Types of emulsifiers and stabilizers used in pharmaceutical industry

Answer 4

Carohydrate + protein substances+ high molecular weight alcohols give
(thikning and stabilizing agent)
O/W emulsions
4- wetting agents such as SLS and SPANS
5-finely divided solids as colloidal clays
Bentonite r +mg/al hydroxide

Question 5

Substance which one substance microscopically dispersed insoluble particles suspended through another substance

Answer 5

Colloid

Question 6

Orally less oil means

Answer 6

Reduced oil means better digestion and absorption

Question 7

;why w/o is better to soften the skin

Answer 7

Because it resests drying and removal by water

While O/W is easily removed

Question 8

On inbroken skin

Answer 8

It is better to use w/o because of the sebum thin film on skin wich is better wetted by oil

Question 9

Is it possible to compound twp incompatable ingreadiants in an emulsion?/////

Answer 9

Yes yes yes

Question 10

HLB system

Answer 10

Hydrophil/lipophil balance

Question 11

Usual HLB and how much can it reach

Answer 11

1-20 and can reach 40

Question 12

Hydrophilic HLB

Hydrophobic HLB

Answer 12

3-6 lipophilic w/o emulsion
8-18 hydrophilic o/w
7-9 wetting agents

Question 13

Emultions vary in viscousty and can be prepared as

Answer 13

Liquids and semisolids

Question 14

Many emultions is calssifed as other forms why examples

Answer 14

Because they fit a]other forms more specifically

Lotions/ointments/creams/lintments/vitamin drops

Question 15

When do we consider an emultion unstable

Answer 15

If it forms aggregates and globules upon standing
2- if large globules or aggregates rise or fall to top/bottom
3-if all the part of liquid seperates to the top or bottom

Question 16

Creaming of emultion

Answer 16

Upward or downword
A reversable process
The cream might be distributed
Should not be dispensed ethitics wise or appealing wise and it increases the risk of colscence

Question 17

Coalesce

Answer 17

Irreversable breaking or cracking in the emultion and destructive to emultion unlike creaming
Might be caused from extreme hot or cold tempretures

Question 18

The rate of seperation factors 3

Answer 18

Size the lower the better
Density difference the lower the better and
The increase outside viscousty is better

Question 19

Thijckners as

Answer 19

Traganth and microcrystalline cellulose

Question 20

Why do we use methylparabine and prophylparaben to preserve emultions

Answer 20

For o/w emultions because it is more common to fungi to grow than bacteria

Question 21

Alcohol added to 12%-15% and paraben are

Answer 21

O/W preservation usually

Question 22

How to dilute
W/O
O/W

Answer 22

W/O by adding oil
O/w by adding water
Always add the external phase

Question 23

How do we prepare emulsions on high scale

Answer 23

By high speed impeller and rendered finer by colloid mill and large homogenizer forces liquid in a great pressure through small valve opening
To produce
100k L/hr