Empiric Broad-spectrum Abx for PNA,UTI,SSTI

Question 1

What abx are used for CAP (community acquired pneumonia)?

Answer 1

Ceftriaxone 1g IV
plus
Azithromycin 500mg IV

OR

Levofloxacin 750mg IV

Question 2

What abx are used for HOSPITAL acquired pna

or

with septic shock?

Answer 2

Vancomycin 25mg/kg IV (max dose is 2g)
plus
Cefepime 2g IV
plus
Azithromycin 500mg IV

Question 3

Abx used for UROSEPSIS?

Answer 3

Ceftriaxone 1g IV

OR

Ciprofloxacin 400mg IV

Consider + Vancomycin 25mg/kg if history of MRSA or Enterococcus infection.

Question 4

Abx for UROSEPSIS w/septic shock:

Answer 4

Cefepime 2g IV

OR

Meropenem 1g IV

Consider + Vancomycin 25mg/kg if history of MRSA or Enterococcus infection.

Question 5

Abx for severe and NON-purulent skin or soft tissue infection:

Answer 5

Vancomycin 25mg/kg IV
plus
Piperacillin/Tazobactam 4.5g IV
OR
Meropenem 1g IV

Consider surgical consultation

Question 6

Severe and PURULENT

Answer 6

Incision and drainage
plus
Vancomycin 25mg/kg
plus
Surgical consultation

Question 7

Abx given with unknown source or concern for intra-abdominal source:

Answer 7

Vancomycin 25mg/kg
plus
Piperacillin/ Tazobactam 4.5g

OR

Meropenem 1g