emma holliday Flashcards
meds to hold before stress test
BBs
CCBs
MC cause of death post MI
arrhythmias
Vfib
persistent ST elevation ~1 mo after MI and systolic MR murmur
ventricular aneurysm
cannon A waves post MI
AV dissociation
V fib or 3rd degree heart block
CP at rest/night, migraine HA
Prinzmetals!
dx ergonovine
tx CCB/nitrates
causes of dilated cardiomyopathy
viral etoh (reversible!) cocaine chagas idiopathic
causes of diastolic HF
HTN
amyloid
hemochromatosis (reversible!)
drugs that improve survival in HF
ace-i
BBs
spironolactone in class III/IV
drugs that improve sx in HF
dig (sx and hosp)
lasix (sx)
pleural effusion w/low glucose
RA
pleural effusion with high lymphocytes
TB
pleural effusion with blood
malignant or PE
transudative pleural effusion
CHF
nephrotic
cirrhotic
dx of ARDS
PF < 200
B/L alveolar infiltrates on CXR
PCWP < 18
indications to start O2 in COPD
PaO2 < 55
SpO2 < 88
new clubbing in COPD
hypertrophyic osteoarthropathy!
get a CXR - most likely underlying malignancy
asthma tx pathway (OP)
albuterol –> add inhaled CS –> add long acting B-ag –> add montelukast and oral steroids
upper lung nodule with eggshell calcifications
silicosis
get yearly TB test
give INH for 9 mos if >1cm
lower lobe reticulonodular process with pleural plaques
asbestosis
MC cancer = bronchogenic carcinoma
patchy lower lobe infiltrates, thermophilic actinomyces
hypersensitivity pneumonitis
popcorn calcification
hamartoma
adenocarcinoma of lung
MC in non smokers
peripheral!
mets to liver, bone, brain, adrenals
effusion: exudative with high hyaluronidase
squamous cell paraneo
PTHrP
low P, high Ca
small cell paraneo
SIADH
Lambert Eaton
Pancoast
Crohn’s buzzwords
fistulae
granulomas
transmural
Q fever
coxiella burnetti
assoc with cows
give doxy
franciella tularensis
assoc with rabbits
give streptomycin, gentamycin
rifampin SEs
orange
CYP450 inductino
INH SEs
peripheral neuropathy and sideroblastic anemia - give pyridoxine
hepatitis with mild LFT bump
pyrazinamide SEs
benign hyperuricemia
ethambutol SEs
optic neuritis
vision abnormalities
tx of endocarditis
strep viridans: PCN
staph: naf+ gent or vanc
zidovudine SEs
GI
leukopenia
macrocytic anemia
didanosine SEs
pancreatitis
peripheral neuropathy
abacavir SEs
HS rash, fever, N/V, muscle aches, SOB in 1st 6 weeks
D/C AND NEVER USE AGAIN
indinavir SEs
nephrolithiasis and hyperbili
efavirenz SEs
sleepy, confused, psycho
HIV post exposure ppx
AZT
lamivudine
nelfinavir
when to add steroids for PCP PNA
PaO2 < 70
Aa gradient > 35
CMV diarrhea in HIV
blood diarrhea
tx: ganciclovir, foscarnet
MAC diarrhea
diarrhea, wasting, fevers, night sweats
tx: clarithro, ethambutol, rifampin
azithro ppx
crypto diarrhea
dog poo, swimming pools
watery with mucus!
acid fast oocysts
HIV with multiple ring enhancing lesions
toxo!
pyrimethamine sulfadiazine + folate
HIV with one ring enhancing lesion
CNS lymphoma, assoc with EBV
tx: HAART
HIV with meningitis sx
think crypto
india ink
ampho –> fluconazole maintenance
HIV with hemisensory loss, visual impairment, Babinskis
PML/JC virus
brain biopsy!
immune suppressed with cavitary lung dz and weight loss
partially acid fast G+ aerobes
nocardia
tx: bactrim
neck/face infection with draining yellow material, G+ anaerobes
actinomyces!
tx: PCN
risk of fast correction of hypoNa
central pontine myelinolysis
risk of fast correction of hyperNa
cerebral edema
type I RTA
distal, can’t excrete H
lithium, SLE, sickle
hypoK
tx: replete K, oral bicarb
type II RTA
proximal, can’t reabsorb HCO3
Fanconi, myeloma, amyloid
hypoK
tx: replete K, mild diuretic
type IV RTA
diabetes, Addisons, sickle
hyper K, hyperCl
tx: fludrocortisone
muddy brown casts w/ ampho, AG, cisplatin, or ischemia
ATN
give fluids
protein, blood, eos in urine w/ bactrim
AIN
stop offending agent + steroids if no improvement
tx rhabdo
bicarb (prevent precipitation)
envelope crystals on UA
ethylene glycol intox
tx: dialysis or NaHCO3
cyclophosphamide SE
hemorrhagic cystitis
hematuria 1-2 d after URI
Bergers (IgA)
hematuria 1-2w after strep
PSGN
get ASO titer
hematuria + hemoptysis
Goodpasture
Ab to collagen IV
hematuria + deafness
Allport
XLR in collagen IV
Wegeners
dx: biopsy
tx: steroids or cyclophosphamide
Churg Strauss
dx: lung bx
tx: cyclophosphamide
PAN
no lung involvement
tx: cyclophosphamide
foley + alkaline pee and stones
struvite stone
proteus! kleb, staph, pseudo
stone + bowel resection for volvulus
pure oxylate stone
stone + leukemia/chemo
uric acid stone
tx: alkalinize urine, hydrate
proteinuria + heroin/HIV
FSGS
limited response to steroids
proteinuria + hepatitis
MPGN
anemia + mycoplasma + cyanosis of fingers/ears/nose
cold AIHA
no steroid response
anemia + PCN/ceph/sulfa/rifampin/cancer
warm AIHA
steroids then splenectomy
dark urine in AM, Budd Chiari, weird thromboses
PNHH
defect in PIG-A, complement lysis
increased risk for aplastic anemia
ITP tx
prednisone
then splenectomy
IVIG if plt < 10k
ritux
recurrent epistaxis, normal plts, increased bleeding time and PTT
VWD
DDAVP for bleeding or pre op
replace fVIII
factors depleted in cirrhosis
1st: VII –> PT increase
2nd: viii and vWF
causes of DIC
sepsis, rhabdo, adenocarcinoma
pancreatitis, snake bites
tx of m3 aml
HIT tx
stop heparin
reverse warfarin with vit K
start lepirudin/other anticoag
clots on heparin
AT III deficiency
leser trelat
eruption of multiple seb keratoses
paraneo: GI, breast, lung, GU
porphyria cutanea tarda
skin blistering in sunlight
uroporphyrinogen decarboxylase deficiency
behcet’s
genital and oral ulcers
ocular, GI, lung involvement possible
thyroid storm tx
PTU
iodine
propranolol
MC thyroid ca
papillary
psammoma bodies
lymph metastasis
follicular thyroid ca
blood spread
excise whole thyroid
medullary thyroid ca
MEN: look for pheo, hyperca
hasimotos and thyroid
predisposes for thyroid lymphoma
screening of adrenal insufficiency
cosyntropin stimulation test
tx of Addison’s
saline resuscitation
dexamethasone and fludrocortisone replacement long term
MEN1
parathyroid hyperplasia
pancreatic islet tumors
pituitary adenomas
MEN2A
medullary thyroid ca
pheo
parathyroid
MEN2B
medullary thyroid ca
pheo
marfans
MCC of death in DM
CV disease
tx subarachnoid hemorrhage
nimodipine to reduce ischemic stroke
L hemiplegia/hemisensory
R MCA stroke
L hemiplegia/hemisensory + confusion, behavior
R ACAstroke
L hemiplegia + R ptosis
R Webber’s stroke (midbrain)
falling to L and R ptosis
R Benedikt’s stroke (PCA or basilar)
tx of partial seizures
carb or phenytoin
then vpa or lamictal
tx generalized seizures
vpa
then lamictal/carb/phenytoin
3 hz spike and wave
absence sz
ethosux
diffuse background slowing on EEG
delirium
hypsarrhythmia
infantile spasms
tx ACTH
tx pseudotumor cerebri
weight loss
acetazolamide
shunt or optic n sheath fenestration
tx myasthenia
IVIG/plex acute
pyridostigmine, GCs/azathioprine, thymectomy chronic
AVOID AGs and BBs
dysphagia in HIV
candida
HSV
CMV
whipples dz
T whipplei
malabsorption diarrhea
weight loss, jt pain
> 20% blasts
acute leukemia
CALLA or TdT
ALL
auer rods, myeloperoxidase, esterase
AML
risks; radiation, downs, myeloprolif
tartrate resistant acid phosphatase, decreased monos, CD11, CD22
hairy cell
tx cladirbine
ALL tx
danorubicin, vincristine, pred
intrathecal MTX if CNS recurrence
BM txp
AML tx
danurubin + araC
if M3 give TRA
bone pain, punched out lesions on XR, hyper CA
MM SPEP BM b BM txp, pred hydrataion and furosemide then bisphosphonates
dizziness, HA, hearing/vision probs, monoconal IgM
Waldenstrom
IG spike found incidentally
MGUS