Emergency department use of oral ondansetron for acute gastroenteritis-related vomiting in infants and children Flashcards

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1
Q

What is the most common cause of physician visits and hospitalizations in infants and young children?

A

Acute gastroenteritis

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2
Q

What is ondansetron?

A

Highly potent and selective serotonin 5-HT3 receptor antagonist

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3
Q

When is the peak plasma concentration of odansetron achieved?

A

Peak [plasma] after 1-2h only

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4
Q

What are the side effects of ondansetron?

A

Diarrhea (mild, self-limiting)

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5
Q

What is single dose oral ondansetron therapy effective for in this population?

A
  1. Reducing frequency of emesis

2. Reducing IV fluid administration

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6
Q

Who should oral ondansetron be considered in?

A

Infants and children 6m-12yo who present to ED with emesis related to suspected acute gastroenteritis and who have either:

  1. mild to moderate dehydration
  2. failed oral rehydration therapy
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7
Q

Which children with gastroenteritis is ondansetron not recommended?

A

Children who’s primary symptom is diarrhea

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8
Q

What is the dosing?

A

8-15kg: 2mg
15-30kg: 4mg
>30kg: 6-8mg

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9
Q

How long after administration of oral ondansetron should oral rehydration therapy be started?

A

15-30min

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