Embryology Additional Flashcards
The midgut (cranial and caudal limbs) return into the abdominal cavity by week
10
Failure of midgut returning into abdominal cavity by week 10 leads to
GI anomalies and abnormal placement of appendix
Besides double bubble x-ray and bilious vomiting, what other sign indicates duodenal atresia?
polyhydramnios
What type of hernia can occur when midgut return normally into abdominal cavity by week 10 but re-herniates through imperfectly closed umbilicus?
Umbilical hernia
What clinical presentation indicates umbilical hernia?
midline protrusion that is covered by skin
What type of hernia can occur due to persistence of herniated midgut that doesn’t return to abdomen cavity by week 10?
Omphalocele
What clinical presentation indicates Omphalocele?
Midline protrusion that is covered by peritoneum-like transparent sac
What type of hernia can occur due to failure of abdominal wall to close after midgut return to abdominal cavity?
Gastroschisis
What clinical presentation indicates Gastroschisis?
NEAR midline protrusion that is not covered at all
Which one has better prognosis? Gastroschisis or Omphalocele
Gastroschisis (whatt!)
What GI anomaly can occur due to lack of cell migration of neural crest cells into distal colon (sigmoid) and rectum causing absence of innervation (Meissner’s and Auerbach’s ganglia) in wall of distal GI?
Hirschsprung’s Disease
What gross pathology indicates Hirschsprung’s Disease?
Constricted aganglionic area (sigmoid/rectum) and dilated proximal area (mega-descending colon)
