Embryology ✅ Flashcards

1
Q

Where does the respiratory tree arise from?

A

The ventral surface of the foregut

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2
Q

What are the phases of lung development?

A
  1. Embryonic phase
  2. Pseudoglandular phase
  3. Canalicular phase
  4. Saccular phase
  5. Term
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3
Q

When does the embryonic phase of lung development occur?

A

3-5 weeks

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4
Q

What happens in the embryonic phase of lung development?

A

The respiratory bud arises from the ventral surface of the foregut

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5
Q

What kind of mesoderm does the respiratory bud arise from?

A

Splanchnic

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6
Q

When does the pseudoglandular phase of lung development occur?

A

6-16 weeks

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7
Q

What is formed in the pseudoglandular phase?

A

Bronchial tree

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8
Q

What develops in parallel to the bronchial tree during the pseudoglandular phase?

A

The arterial supply to each lung

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9
Q

What is the result of the arterial supply of each lung arising parallel to the bronchial tree?

A

Arteries are found alongside each airway, a pattern that persists into adulthood

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10
Q

When do the pulmonary veins develop?

A

At a similar time to the arteries and bronchial tree

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11
Q

Do the pulmonary veins accompany the airways?

A

No

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12
Q

Where do the pulmonary veins lie?

A

In the intersegmental plane

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13
Q

When is smooth muscle present in the trachea and bronchi from?

A

10 weeks

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14
Q

When does cartilage develop in the respiratory system?

A

6 weeks

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15
Q

When are ciliated cells seen?

A

12 weeks onwards

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16
Q

When is the canalicular phase of respiratory development?

A

17-24 weeks

17
Q

What happens in the canalicular phase of lung development?

A
  • Distal airways develop

- Epithelial cells subdivide into type I pneumocytes and type II pneumocytes

18
Q

What is the purpose of type I pneumocytes?

A

Gas exchange

19
Q

What is the purpose of type II pneumocytes?

A

Surfactant production

20
Q

When is the saccular phase of lung development?

A

24 weeks - term

21
Q

What happens in the saccular phase of lung development?

A

Terminal sacs, alveolar ducts, and finally alveoli form, increasing surfactant production from 24 weeks

22
Q

How to the lungs of a term neonate compare to adults?

A

They have 1/5 of the number of alveoli

23
Q

What happens to alveoli during childhood?

A

Alveolar multiplication and maturation continues into early childhood

24
Q

What can abnormal embryological development of the lungs lead to?

A

Congenital thoracic malformations (CTMs)

25
Q

Give 7 examples of abnormal embryological development of the lungs?

A
  • Failure of complete separation of the foregut and bronchial structures
  • Congenital pulmonary airway malformations
  • Pulmonary sequestration from abnormal blood supply to part of the lung
  • Congenital diaphragmatic hernia
  • Cysts
  • Congenital lobar emphysema
  • Lung agenesis/bronchial atresia
26
Q

What does failure of separation of the foregut and bronchial structures lead to?

A

Different types of tracheo-oesophageal fistula

27
Q

What causes congenital pulmonary airway malformations?

A

Abnormal development of alveolar or bronchial tissues

28
Q

Is pulmonary sequestration from an abnormal blood supply to part of the lung systemic or pulmonary?

A

Usually systemic

29
Q

What causes congenital diaphragmatic hernia?

A

Maldevelopment of the pleuroperitoneal canal

30
Q

What are the types of cysts that can arise due to abnormal embryological development of the lungs?

A
  • Bronchogenic

- Foregut

31
Q

What causes congenital lobar emphysema?

A

Partial obstruction of the developing airway

32
Q

What is the most common cause of partial obstruction of the developing airway leading to congenital emphysema?

A

Deficiency of bronchial cartilage development

33
Q

What causes lung agenesis/bronchial atresia?

A

Maldevelopment of the bronchial tree in early fetal life