Embryology Flashcards

1
Q

How does the midgut remain connected to the yolk sac

A

Via the vitelline duct

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2
Q

What does the foregut form

A

Oesophagus

Stomach

Pancreas

Liver

Gall bladder

Duodenum - proximal to bile duct

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3
Q

What does the midgut form

A

Duodenum - distal to bile duct

Jejunum

Ileum

Caecum

Ascending colon

Proximal 2/3 of transverse colon

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4
Q

What does the hindgut form

A

Distal 1/3 of transverse colon

Descending and sigmoid colon

Rectum

Upper anal canal

Internal lining of bladder and urethra

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5
Q

What forms the stroma, muscle, CT and peritoneal components of the gut wall

A

The visceral mesoderm

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6
Q

What is the blood supply of the primitive gut tube

A

Foregut - celiac trunk

Midgut - superior mesenteric artery

Hindgut - inferior mesenteric artery

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7
Q

What are mesenteries

A

Double layers of peritoneum that enclose an organ and connect it to the body wall - neurovascular supply runs in mesentery

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8
Q

What are peritoneal ligaments

A

Double layers of peritoneum that pass from one organ to another or from an organ to the body wall

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9
Q

What does the dorsal mesentery form in the following regions:

Stomach

Duodenum

Colon

A

Stomach - forms greater omentum/dorsal mesogastrium

Duodenum - forms dorsal mesoduodenum

Colon - forms dorsal mesocolon

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10
Q

What does the ventral mesentery divide into and what causes this divide

A

Liver growth cause the ventral mesentery to divide into:

Lesser omentum

Falciform ligament - liver to ventral body wall

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11
Q

Describe what happens during the oesophagus development

A

In 4th week, respiratory diverticulum/lung bud appears in ventral wall of foregut

Tracheoesophageal septum then separates diverticulum from dorsal part of foregut to divide the foregut into respiratory primordium and oesophagus

Oesophagus develops rapidly as heart and lungs descend

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12
Q

Describe rotation of the stomach and how this affects nerve innervation

A

Stomach rotates 90o clockwise around its longitudinal axis -> left side faces anteriorly and right side faces posteriorly

Original posterior wall grows faster during rotation so have formation of greater and lesser curvatures

Causes left vagus nerve to innervate anterior wall and right vagus nerve to innervate posterior wall

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13
Q

How is the lesser sac formed

A

Rotation of stomach around longitudinal axis pulls dorsal mesogastrium left to create lesser sac behind the stomach

Rotation also pulls ventral mesogastrium right

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14
Q

Describe the formation of the spleen - where it develops and where it ends up

A

Spleen primordium appears as mesodermal proliferation between two leaves of dorsal mesogastrium

As rotation continues, spleen is pushed left and the dorsal mesogastrium between the spleen and dorsal midline fuses with peritoneum of posterior abdominal wall

Spleen is conencted to body wall by lienorenal ligament and to the stomach by gastrolienal ligament

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15
Q

How is the greater omentum formed

A

Stomach rotation around anteroposterior axis causes dorsal mesogatrium to bulge down and continue to grow downwards to form double-layered sac extending over the transverse colon and small intestinal loops

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16
Q

Why is there a bare area of the liver on its superior surface

A

Mesoderm on liver surface differentiates into visceral peritoneum expect on cranial surface where liver remains in contact with septum transversum - forms central tendon of the diaphram

17
Q

What is the accessory pancreatic duct

A

A duct which remains if the proximal part of the dorsal pancreatic duct does not obliterate

18
Q

Where do the main and accessory pancreatic ducts enter the duodenum

A

Main duct - major papilla

Accessory duct - minor papilla

19
Q

What does the cephalic limb of the primary intestinal loop form

A

Distal duodenum

Jejunum

Part of the ileum

20
Q

What does the caudal limb of the primary intesrinal loop form

A

Distal ileum

Caecum

Appendix

Ascending colon

Proximal 2/3 of transverse colon

21
Q

Describe physiological herniation

A

During 6th week, primary intestinal loop enters the extraembyronic cavity in the unbilical cord due to the abdominal cavity becoming too small to contain the intestinal loops

22
Q

Describe rotation of the midgut

A

Primary intestinal loop 90o counterclockwise around the axis formed by superior mesenteric artery - occurs three times

During each rotation, elongation continues

23
Q

Describe how the herniated loops return into the abdominal cavity

A

During 10th week, herniated loops return to abdominal cavity

Proximal jejunum re-enters first -> lies on left side

24
Q

Describe the development and movement of the cecal bud

A

Cecal bud forms in 6th week as a small dilation of caudal limb

It is the last part of the gut to re-enter the cavity

Initally lies below the right lobe of the liver before descending into the right iliac fossa to place the ascending colon and hepatic flexure on the right side of the abdominal cavity

Distal end of cecal bud forms appendix

25
Q

What happens to the mesenteries of the ascending and descending colons after they find their final positions

A

The mesenteries press against the peritoneum of the posterior wall and then the layers fuse

This results in the ascending and descending colons becoming retroperitoneal

26
Q

What happens to the transverse mesocolon during development

A

Transverse mesocolon fuses with posterior wall of greater omentum but retains its motility

27
Q

Describe how the mesentery of the jejunoileal loops changes its attachment site

A

At the start, jejunoileal loop mesentery is continuous with mesentery of ascending colon

Once ascending colon mesentery fuses with posterior wall, mesentery of jejunoileal loop forms a new line of attachment to keep it mobile

28
Q

What is the cloaca

A

Endoderm-lined cavity covered at its ventral boundary by surface ectoderm

Boundary between endoderm and ectoderm forms cloacal membrane

29
Q

What is the anal canal derived from and what divides the anal canal

A

Upper 2/3 of anal canal is from endoderm of hindgut

Lower 1/3 of canal is from ectoderm

Anal canal is divided by the pectinate line

30
Q

Describe the cranial part of the anal canal - neurovasculature, lymph and epithelium

A

Cranial part of anal canal:

Superior rectal artery from inferior mesenteric artery

Innervated by visceral nerves - S2,3,4 pelvic parasympathetic

Columnar Epithelium

Internal iliac nodes

31
Q

Describe the caudal part of the anal canal - neurovasculature, lymph and epithelium

A

Caudal part of the anal canal:

Inferior rectal arteries from internal pudendal

Somatic nerves - pudendal nerve (S2,3,4)

Stratified squamous epithelium

Superficial inguinal nodes