Elimination and substitution reactions Flashcards
What type of reaction occurs with a strong base and weak nucleophile for a 1° substrate?
E2.
What type of reaction occurs with a strong base and weak nucleophile for a 2° substrate?
E2.
What type of reaction occurs with a strong base and weak nucleophile for a 3° substrate?
E2.
What type of reaction occurs with a strong base and strong nucleophile for a 1° substrate?
SN2 (major) and E2 (minor).
What type of reaction occurs with a strong base and strong nucleophile for a 2° substrate?
E2 (major) and SN2 (minor).
What type of reaction occurs with a strong base and strong nucleophile for a 3° substrate?
E2.
What type of reaction occurs with a weak base and strong nucleophile for a 1° substrate?
SN2.
What type of reaction occurs with a weak base and strong nucleophile for a 2° substrate?
SN2.
What type of reaction occurs with a weak base and strong nucleophile for a 3° substrate?
SN1.
What type of reaction occurs with a weak base and weak nucleophile for a 1° or 2° substrate?
No reaction.
What type of reaction occurs with a weak base and weak nucleophile for a 3° substrate?
SN1 (major) and E1 (minor).
What are examples of strong bases and weak nucleophiles?
DBN, DBU.
What are examples of strong bases and strong nucleophiles?
NaOH, NaOMe, NaOEt.
What are examples of weak bases and strong nucleophiles?
NaI, NaBr, NaCl, NaSH, NaSR, H₂S, RSH.
What are examples of weak bases and weak nucleophiles?
H₂O, MeOH, EtOH.
DBN is an example of which type of reagent?
Strong base and weak nucleophile.
DBU is an example of which type of reagent?
Strong base and weak nucleophile.
NaOH is an example of which type of reagent?
Strong base and strong nucleophile.
NaOMe is an example of which type of reagent?
Strong base and strong nucleophile.
NaOEt is an example of which type of reagent?
Strong base and strong nucleophile.
NaI is an example of which type of reagent?
Weak base and strong nucleophile.
NaBr is an example of which type of reagent?
Weak base and strong nucleophile.
NaCl is an example of which type of reagent?
Weak base and strong nucleophile.
NaSH is an example of which type of reagent?
Weak base and strong nucleophile.
NaSR is an example of which type of reagent?
Weak base and strong nucleophile.
H₂S is an example of which type of reagent?
Weak base and strong nucleophile.
RSH is an example of which type of reagent?
Weak base and strong nucleophile.
H₂O is an example of which type of reagent?
Weak base and weak nucleophile.
MeOH is an example of which type of reagent?
Weak base and weak nucleophile.
EtOH is an example of which type of reagent?
Weak base and weak nucleophile.
