Elimination and substitution reactions

Question 1

What type of reaction occurs with a strong base and weak nucleophile for a 1° substrate?

Answer 1

E2.

Question 2

What type of reaction occurs with a strong base and weak nucleophile for a 2° substrate?

Answer 2

E2.

Question 3

What type of reaction occurs with a strong base and weak nucleophile for a 3° substrate?

Answer 3

E2.

Question 4

What type of reaction occurs with a strong base and strong nucleophile for a 1° substrate?

Answer 4

SN2 (major) and E2 (minor).

Question 5

What type of reaction occurs with a strong base and strong nucleophile for a 2° substrate?

Answer 5

E2 (major) and SN2 (minor).

Question 6

What type of reaction occurs with a strong base and strong nucleophile for a 3° substrate?

Answer 6

E2.

Question 7

What type of reaction occurs with a weak base and strong nucleophile for a 1° substrate?

Answer 7

SN2.

Question 8

What type of reaction occurs with a weak base and strong nucleophile for a 2° substrate?

Answer 8

SN2.

Question 9

What type of reaction occurs with a weak base and strong nucleophile for a 3° substrate?

Answer 9

SN1.

Question 10

What type of reaction occurs with a weak base and weak nucleophile for a 1° or 2° substrate?

Answer 10

No reaction.

Question 11

What type of reaction occurs with a weak base and weak nucleophile for a 3° substrate?

Answer 11

SN1 (major) and E1 (minor).

Question 12

What are examples of strong bases and weak nucleophiles?

Answer 12

DBN, DBU.

Question 13

What are examples of strong bases and strong nucleophiles?

Answer 13

NaOH, NaOMe, NaOEt.

Question 14

What are examples of weak bases and strong nucleophiles?

Answer 14

NaI, NaBr, NaCl, NaSH, NaSR, H₂S, RSH.

Question 15

What are examples of weak bases and weak nucleophiles?

Answer 15

H₂O, MeOH, EtOH.

Question 16

DBN is an example of which type of reagent?

Answer 16

Strong base and weak nucleophile.

Question 17

DBU is an example of which type of reagent?

Answer 17

Strong base and weak nucleophile.

Question 18

NaOH is an example of which type of reagent?

Answer 18

Strong base and strong nucleophile.

Question 19

NaOMe is an example of which type of reagent?

Answer 19

Strong base and strong nucleophile.

Question 20

NaOEt is an example of which type of reagent?

Answer 20

Strong base and strong nucleophile.

Question 21

NaI is an example of which type of reagent?

Answer 21

Weak base and strong nucleophile.

Question 22

NaBr is an example of which type of reagent?

Answer 22

Weak base and strong nucleophile.

Question 23

NaCl is an example of which type of reagent?

Answer 23

Weak base and strong nucleophile.

Question 24

NaSH is an example of which type of reagent?

Answer 24

Weak base and strong nucleophile.

Question 25

NaSR is an example of which type of reagent?

Answer 25

Weak base and strong nucleophile.

Question 26

H₂S is an example of which type of reagent?

Answer 26

Weak base and strong nucleophile.

Question 27

RSH is an example of which type of reagent?

Answer 27

Weak base and strong nucleophile.

Question 28

H₂O is an example of which type of reagent?

Answer 28

Weak base and weak nucleophile.

Question 29

MeOH is an example of which type of reagent?

Answer 29

Weak base and weak nucleophile.

Question 30

EtOH is an example of which type of reagent?

Answer 30

Weak base and weak nucleophile.