EL1 Flashcards
What is gating?
the process by which ion channel opening and closing is controlled.
ie voltage gated ion channel.
What is the G protein Gs coupled to?
Adenylate cyclase (positively)
What is IP3?
Inositol tris-phosphate.
a second messenger produced in the phospholipase C pathway.
coupled to Gq.
what is transrepression?
the process by which nuclear hormone receptors decrease expression of a protein.
What is the structure of a ligand gated ion channel?
4 transmembrane domains.
N terminus extracellular.
large loop between TM3 and TM4. TM2 forms lining of channel
what receptor class is most frequently targetted by drugs?
G protein coupled receptors.
what is an orphan receptor?
a receptor for which the endogenous ligand is not known.
what is phosphlipase C linked to?
Gq
What is transactivation?
process by which NHR increase expression of a protein.
What is the structure of a voltage gated sodium/calcium channel?
24 TM domains, 4 psuedo subunits.
TM4 is the voltage sensor.
membrane dipping loop between TM5 and TM6.
N terminus intracellular.
What is a G protein coupled receptor?
receptor for a neurotransmitter, hormone or other signalling molecule that is coupled to intracellular signalling pathways via G proteins.
What is a G protein?
name
guanine nucleotide binding protein.
links GPCR to intracellular signalling pathways.
Trimeric - alpha, beta, gamma.
Gs, Gi, Gq main types.
built in GTPase enzyme activity.
what is the most diverse receptor class?
GPCR.
what is Gi coupled to?
adenylate cyclase (negatively)
where are NHR usually present?
cytoplasm
