Effects of recreational drugs Flashcards

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1
Q

Define a recreational drug

A

A drug that hasn’t been medically perscribed and has been consumed for the sole purpose of enjoyment.

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2
Q

Define an agonist drug

A

attach to receptors and mimic the effect of a neurotransmitter

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3
Q

Define an antagonist drug

A

Block receptors so that neurotrasmitters cant fit into them

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4
Q

What is an example of 3 recreational drugs

A

Cocaine
Heroin
Ecstasy

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5
Q

Cocaine:

What effect does cocaine have on the CNS

A

A stimulant effect, especially on the brain’s main reward system.

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6
Q

Cocaine:

how does this drug acheive it’s effect

A

altering synaptic transmission involving several neurotransmitters (noradrenaline, serotonin and acetycholine).

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7
Q

Cocaine:

How does cocaine increase dopamine levels

A

blocks reuptake of dopamine by binding to dopamine transport molecules in the presynaptic neuron

  • free dopamine is forced to bind to postsynaptic receptor
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8
Q

Cocaine:

What happens to dopamine receptors after repeated use

A

Receptors become downregulated

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9
Q

Cocaine:

If a receptor is ‘downregulated’ what does that mean?

A

receptors are…
- damaged
- not working
- quantity of dopamine produced while sober decreases

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10
Q

Heroin:

What effetc does heroin have on the CNS

A

depressant effect, slows CNS activity including activity of neurons involved in pain.

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11
Q

Heroin:

What receptor does heroin bind to in the synapse?

A

mu (opioid) receptor found in cerebral cortex, limbic system and hypothalamus.

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12
Q

Heroin:

What’s the mode of action of Heroin

A

Agonist, mimics the effect of another natural biochemical

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13
Q

Heroin:

What are the long term effects of heroin use

A

Downregulation of opioid receptors on postsynaptic neuron

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14
Q

Ecstacy:

What effect does ecstacy have on the CNS

A

Stimulant, block reuptake of serotonin at the synapse, but also significantly increases output of serotonin

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15
Q

Strength of research evidence:

What is a strength of research evidence

A

Research evidence supporting the role of dopamine in non-human animals

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16
Q

Strength of research evidence:

What procedure of the research evidence supports this

A

deliberately damaging mesocorticolimbic pathway in mice brain
- neurons unable to produce levels of dopamine normally associated with reward

17
Q

Strength of research evidence:

What were the results of the study on damaging mesocorticolimbic pathway in mice brain

A

mice failed to self-administer cocaine into their veins.
- showed cocaine’s effects were due to activity of dopamine in brain’s reward system

18
Q

Weakness of validity:

What is a weakness of the validity of this area

A

Most studies use non-human animals to study drug effect on CNS transmission.

19
Q

Weakness of validity:

Why is using non-human animals a weakness

A

Although there’s similarities between the CNS, the human brain is more complex
- isolating the effects of one neurotransmitter greatly oversimplifies the process

20
Q

Weakness of validity:

What does this mean

A

Generalising from animals to humans should be done with causion