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Pharmacology drug classes > Effects of CPR drugs > Flashcards

Effects of CPR drugs Flashcards

1
Q

Epinephrine- general effect

A

Mixed adrenergic agonist- get increased systolic BP but decreased peripheral that leaves the mean BP normal, get increased HR, bronchodilation, decreased bronchial secretions, muscle tremors, increased potassium influx in muscle, increased blood glucose due to gluconeogenesis, increased renin, increased free fatty acids

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2
Q

Norepinephrine- general effect

A

Mixed adrenergic agonist- Does not work on beta 2 so get dramatic raise in peripherial resistance that will cause a dramatic increase in blood pressure and reflexive decrease in heart rate

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3
Q

Phenylephrine- general effect

A

alpha 1 adrenergic agonist- causes vasoconstriction so increased BP that causes a reflexive decrease in blood pressure

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4
Q

Clonidine- general effect

A

alpha 2 adrenergic agonist- causes a decrease in sympathetic stimulation by activating the inhibitor on presynaptic cells, get bradycardia, decreased BP

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5
Q

Dobutamine- general effect

A

Beta 1 adrenergic agonist- causes increased contractility and force of heart *** if the positive isomer is used you get alpha one antagonistic action that causes a decrease in blood pressure.

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6
Q

Isoproterenol- general effect

A

Beta 1/2 adrenergic agonist- causes increased contractility from B1 but get vasodilation in skeletal muscle from B2 so see a decrease in blood pressure. Also get bronchodilation and decreased mucus secretion

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7
Q

Albuterol- general effect

A

Beta 2 agonist- causes bronchodilation and decreased bronchial mucus secretion

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8
Q

Amphetamine- General effect

A

An indirect adrenergic agonist- works by inhibiting uptake of NE and DA from receptors, facilitates their release and some direct effect- causes increased mood/alertness, decreased appetite

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9
Q

Methylphenidate- general effect

A

An indirect adrenergic agonist- works by inhibiting uptake of NE and DA from receptors, facilitates their release and some direct effect- causes increased mood/alertness and decreased appetite

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10
Q

Cocaine- general effect

A

An indirect adrenergic agonist- works by inhibiting NE and DA uptake- causes psychosis, increased HR BP and cardiac output, also see anesthetic properties when applied locally

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11
Q

Ephedrine- General Effect

A

An indirect adrenergic agonist- works by releasing stored catecholamines and having some direct effect- Very similar to epinephrine- causes vasoconstriction and decreased BP

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12
Q

Phenelzine- general effect

A

An indirect adrenergic agonist- works by inhibiting MOA- get localized effects

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13
Q

Selegiline- general effect

A

An indirect adrenergic agonist- works by inhibiting MOA- get localized effects

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14
Q

Tyramine- general effects

A

An indirect adrenergic agonist- works by stimulating release of NE and DA- Seen in cured meats, cheese and pickled fish- Causes an increase in blood pressure

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15
Q

Phentolamine- general effects

A

An alpha non selective antagonist- works by reversibly binding to receptor- causes a decrease in BP and get a reflexive increase in HR. Also seen SM relaxation of the prostate, miosis, and decreased resistance to urine flow.

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16
Q

Phenoxybenzamine- general effects

A

An alpha non selective antagonist- works by irreversibly binding to receptors- causes a decrease in BP and get a reflexive increase in HR. Also seen SM relaxation of the prostate, miosis, and decreased resistance to urine flow

17
Q

Prazosin, tamsulosin and doxazosin- general effect

A

An alpha one antagonist- causes a decreased BP, decreased peripheral resistance, smooth muscle relaxation to the prostate and miosis

18
Q

Labetalol- general effect

A

A partial mixed adrenergic antagonist- Get a decreased BP, HR and contractility. Slower AV conduction, renin inhibition, increased airway resistance and decreased intraocular pressure

19
Q

Carvedilol- general effect

A

An inverse mixed adrenergic antagonist-Get a decreased BP, HR and contractility. Slower AV conduction, renin inhibition, increased airway resistance and decreased intraocular pressure

20
Q

Propranolol, pindolol and nadolol- general effect

A

A non selective beta antagonist- A decreased CO, slowing AV conduction, decreased BP, decreased renin, increased airway resistance, decreased aqueous humor, increased VLDL and decreased HDL and stops lipolysis/gluconeogenesis

21
Q

Metoprolol, Betaxolol, Acebutalol and Atenolol- general effect

A

A beta one antagonist- decreased BP, decreased CO, slowing of AV conduction and decreased renin

22
Q

Direct Acting cholinergics- General effects

A

You get parasympathetic stimulation- so pupil constriction; decreased SA, AV, refractory period and atria contractility; bronchoconstriction; increased gut motility, decreased sphincter tone and increased secretion
Also get muscle fasiculations due to nAChR stimulation

23
Q

AchE inhibitor- General effects

A

You get similar effects to direct acting- Major difference is whether or not they get brain involvement. Parasympatheics = so pupil constriction; decreased SA, AV, refractory period and atria contractility; bronchoconstriction; increased gut motility, decreased sphincter tone and increased secretion

24
Q

Antimuscarinics - general effects

A

General CNS depression, myadrisis, decreased lacrimation, decreased salivation, get tachycardia but no real BP changes; bronchodilation and decreased gut motiliy; relaxes ureters and bladder wall

25
Q

Terazosin and doxazosin- general effects

A

alpha 1 nonselective antagonist- reduces detrusor spasm and prostate smooth muscle relaxation.

26
Q

Tamsulosin and silodosin- general effects

A

Alpha 1 antagonist that works specifically on alpha1A and Alpha1D- reduces detrusor spasm and prostate smooth muscle relaxation.

27
Q

Afluzosin- general effects

A

alpha 1 nonselective antagonist- reduces detrusor spasm and prostate smooth muscle relaxation. ** works preferentially on urogenitary system

28
Q

Finasteride and dutasteride- general effects

A

Inhibits 5 alpha reductase that causes a decrease in prostate size by reducing the amount of DHT in the system

29
Q

Sildenafil, Vardenafil, Tadalafil and Avanafil- general effects

A

Erections

30
Q

Alprostadil- general effects

A

Erections

Pharmacology drug classes (6 decks)

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