EFFECTS OF ADRENERGIC AGONISTS AT RECEPTORS Flashcards

1
Q

When stimulated by adrenergic agonist drugs, what physiological effects do alpha 1 receptors do?

A

There will be an increased heart rate and contraction; vasoconstriction of blood vessels, increasing blood pressure; dilation of pupils (mydriasis); decreased secretion of salivary glands; increased relaxation of urinary bladder and urinary sphincter.

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2
Q

The patient took an adrenergic agonist drug mostly for alpha 1 receptor, what effects do you expect?

A

Increased blood pressure, dilation of pupils, increased urination, and decreased secretion from salivary glands

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3
Q

The patient just took an adrenergic agonist drug mostly affecting the Alpha 2 receptor, what effects do you expect?

A

Since adrenergic agonist drugs inhibits release of norepinephrine, vasodilation will occur, so hypotension occurs. Alpha 2 receptors act when too much stimulation by the alpha 1 receptor occurs. Alpha 2 also decreases gastrointestinal motility and tone.

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4
Q

Where are alpha-adrenergic receptors located?

A

Vascular tissue (vessels) in muscles.

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5
Q

Where is the alpha 2 receptor located?

A

Postganglionic sympathetic nerve endings.

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6
Q

Which neurotransmitter do adrenergic agonists mimic? From which system?

A

Sympathetic Nervous System’s neurotransmitter(s) norepinephrine and epinephrine

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7
Q

Which organs do beta 1 receptors stimulate?

A

Heart and kidneys

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8
Q

What physiological effects occur when beta 1 receptors are stimulated?

A

The kidneys increase release of renin which increases blood pressure. So there will be an increase in heart rate and contraction

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9
Q

What physiological effects occur when beta 2 receptors are stimulated?

A

Dilation of bronchioles; promotes gastrointestinal and uterine relaxation; increased blood sugar; and increases blood flow in skeletal muscles

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10
Q

What kind of patients will benefit from adrenergic agonist drugs affecting beta 2 receptors?

A

Commonly those who have trouble breathing; COPD patients, patients with asthma

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11
Q

Which adrenergic receptor can only be activated by dopamine?

A

Dopaminergic receptor

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12
Q

What is the role of dopaminergic receptor?

A

When stimulated, the vessels dilate and blood flow increases

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