ED + Ortho Flashcards
Serotonin syndrome- medications
TCA MAOIs SSRI St Johns Wart Amphetamines Tramadol
Serotonin syndrome clinical featuress
Hyperreflexia, tremor, clonus (greater in lower extremities)
Autonomic instability- hypertensive, tachycardia
Agitations
Diaphoresis
Mydriasis
Increased bowel sounds and diarrhoea
Abrupt onset, rapidly resolving
Neuroleptic malignant syndrome
Idiosyncratic reaction to neuroleptic or antipsychotic drugs
Onset 4-14 days post commencement of Rx
Rx is stopping meds immediately
SYmptoms resolve within 1-2 weeks
Neuroleptic malignant syndrome clinical features
Hyperthermia, sweating Autonomic dysfunction- unstable BP Stupor Gradual onset, prolonged course DIffuse rigifity, decreased reflexes Normal pupils
Beta blocker overdose
Altered mental status
Bradycardia- ECG can show sinus brady, abnormal AV node conduction or accelerated junctional rhythm
Hypotension
Rx: glucagon
Digoxin overdose
Altered mental status, bradycardia, hypotension
Hyperkalaemia (distiguishes from beta blocker)
Also AV dissociation (1st-3rd degree heart block)
Rx: digoxin-specific antibody
Calcium channel blocker overdose
Altered mental status
Bradycardia- ECG can show sinus brady, abnormal AV node conduction or accelerated junctional rhythm
Hypotension
Rx: high dose insulin therapy (increases ionotropy)
TCA overdose
Rapid onset (1-2 hours) of: Sedation and coma Seizures Tachycardia, hypotension Broad complex dysrythmias eg. long QT Anticholinergic syndrome
QRS >100ms is predictive of seizures
QRS >160ms is predictive of ventricular arrhytmias
Rx: sodium bicarbonate
Colchicine overdose
Rapidly absorbed- peak serum concentration after 30 mins- 3 hours
50% protein bound
Gastro Sx within 24 hours
Mortality:
>0.5mg/kg = 10%
>0.8mg/kg = 100%
No antidote- give charcoal
Activated charcoal not useful or contraindicated
PHALIS
Pesticides, pertoleum distilates Hydrocarbon (eg. inhalant abuse), heavy metals, >1 hour since ingestion Acids, alkali, alcohols Iron Lithium Solvents
One pill kill drugs
+
One mouthful can kill
Sodium channel blockers- hydroxychloroquine, propanolol, TCA, atropine
Calcium channel blockers- verapamil, diltiazem
Theophyline SR
Sulfonylureas
Amphetamines and ecstasy
Opiates- methadone, morphine, oxycodone
Colchicine
Organophosphates/carbamates Paraquat Napthalene (1 mothball) Camphor Hydrocarbons- kerosene, eucalyptus oil, solvents
Toxicology- things that are bad for fetuses
Carbon monoxide
Methhaemaglobin inducing agents- napthalene, dapsone
Lead
Salicylates
Anticholinergic examples
Atropine, scopolamine, glycopyrulate, benztropine, antihistamines
Anticholingeric clinical features
Tachycardia, hypertension Hyperthermic Mydriasis Absent bowel sounds Dry flushed skin Urinary retention Altered CNS, agitated (Mad as a hatter, dry as a bone, blind as a bat, hot as a desert, red as a beet)
Cholinergic examples
Organic phosphate compounds, pilocarpine, mushrooms
Cholinergic clinical features
Miosis, increased bowel sounds at diarrhoea, sweaty Vomiting Urination Lacrimation Bradycardia SLUDGE BBB
Opiod OD clinical features
Hypotensive, bradycardic Slow RR Cold Miosis Absent bowel sounds Dry skin
Sympathomimetic examples
Caffeine, cocaine, amphetamines, ritalin, LSD, theophyline, MDMA
Sympathomimetic clincial features
Tachycardic, hypertensive, tachypnoeic, hyperthermic
Mydriasis
Increased bowel sounds
Sweaty
Sedaive-hypnotic OD clinical features
Hypotensive, bradycardic, low RR, hypothermic
Absent bowel sounds
No change in pupils- distiguisges from opiates
Isoniazid OD
Pyridoxime
Methemoglobinaemia Rx
Methylene blue
Ethylene glycol OD Rx
Ethanol
Fomipazole
Iron OD Rx
Desferroxamine
Sulphoyulureas OD Rx
Octreotide (inhibitis insulin release)
Benzo OD Rx
Flumazanil
% of children with major abdominal trauma requiring operative intervention
<15%
% of children admitted to paediatric trauma centre with abdo injuries
~8%