Eczema and dermatitis Flashcards

1
Q

T/F

Exogenous eczema means spongiotic dermatoses caused by things contacting the skin

A

True

mainly treat by removing the trigger

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2
Q

What are the causes of exogenous eczemas?

A
Irritant contact dermatitis
Allergic contact dermatitis
Photoallergic contact dermatitis
Phototoxic contact dermatitis inc phytophotodermatitis 
Eczematous PMLE
Dermatophytide (Id reaction)
Infectious eczema e.g. Discoid
Post-traumatic eczema
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3
Q

T/F

phototoxic drug reactions are a type of Exogenous eczema

A

False
phototoxic drug reactions are sunburn like rather than eczematous if due to systemic drugs
Phototoxic contact dermatitis is an exogenous eczema

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4
Q

T/F

generalized endogenous eczema is a valid diagnosis in elderly people

A

True

If doesnt fit a recognised type and no exogenous cause found

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5
Q

T/F

All eczematous dermatoses have acute, subacute and chronic lesions

A

False
eczema does but many other have single charcteristic appearances which are often acute
e.g. pompholyx, phytophotodermatitis

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6
Q

T/F

Autoeczematization means the same as dermatophytide or ‘Id’ reaction

A

False
Autoeczematization is secondary dissemination of eczema
‘Id reaction’ or ‘dermatophytide’ etc is used if the primary site is infection rather than eczema

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7
Q

Whic type of eczema most commonly causes autoeczematization?

A

stasis dermatitis

Also, regardless of cause, more likely if primary eczema site is on feet or legs

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8
Q

T/F

Typical for hand eczemas to spread to feet and vice versa

A

True

autoeczematization

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9
Q

T/F

Autoeczematization only occurs in long established eczemas

A

False

Eczema may have been present for any duration of time before spread

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10
Q

T/F

Dissemination (autoeczematization) often follows a local flare

A

True

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11
Q

How does autoeczematization present?

A

Often the eruption is symmetrical and striking
Starts as oedematous papules or papulovesicles or sometimes macules or wheals – soon become eczematous lesions
Can become generalized, can become erythroderma

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12
Q

T/F

Autoeczematization responds to Rx of the primary site but worsens if primary site worsens

A

True

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13
Q

What is meant by ‘conditioned hyperirritability’?

A

Skin away from the eczema site is more prone to flare up from irritants than normal skin
o Can be the cause for high proportion of irritant reactions to patch tests and the ‘angry back’ syndrome
o Unclear if this is the real cause of autoeczematisation reactions

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14
Q

T/F

Eczematous (spongiotic) drug reactions are a type of Exogenous eczema

A

False

Classified as endogenous as not due to something contacting the skin

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15
Q

What are the clinical appearances of eczematous drug eruptions?

A
Localized eczema
Generalized eczema (AD-like) 
seb derm-like
Erythroderma
Pompholyx (esp IVIg)
Baboon syndrome subtype of ‘systemic contact-type dermatitis (medicamentosa)’
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16
Q

T/F

SDRIFE is the same thing as Baboon syndrome as a presentation of systemic contact dermatitis

A

False
Look the same and both called Baboon syndrome but Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE) is a clinical pattern of drug reaction caused by a normal oral drug exposure not oral ingestion of a contact allergen

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17
Q

T/F

Phenytoin is a classic cause of a widespread eczematous eruption which can involve flexures resembling atopic dermatitis

A

False

this is Carbamazepine

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18
Q

T/F

IVIg can cause cheiropompholyx

A

True

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19
Q

What is systemic contact-type dermatitis (medicamentosa)?

A

AKA ‘systemically reactivated contact dermatitis’ or ‘systemic contact dermatitis’
whereby a rash is precipitated by ingestion of a drug or compound to which the patient has a contact allergy due to prior physical contact of the same or a related compound
Can present as Baboon syndrome or another clinical pattern

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20
Q

What are the causes of systemic contact dermatitis?

A

Many
People sensitive to balsam of Peru can get rcns to ingested Cinnamon, vanilla, cloves or inhalation of tincture of benzoin
Pts sensitized to nickel, chromium, parabens, propylene glycol or sorbic acid can get rcns when these are ingested

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21
Q

Which allergens are associated with the Baboon syndrome presentation of systemic conatct dermatitis?

A

Nickel, chromium, balsam of Peru

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22
Q

T/F

systemic contact dermatitis often first or most severely affects site of prior ACD

A

True

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23
Q

T/F

systemic contact dermatitis is often symmetrical

A

True

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24
Q

T/F

Contact sensitization to neomycin can result in systemic contact dermatitis when gentamicin is given

A

True

also if given systemic neomycin

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25
T/F | Contact sensitization to thiurams can result in systemic contact dermatitis when aminophylline is given
False | when disulfiram is given
26
T/F | Contact sensitization to ethylenediamine can result in systemic contact dermatitis when aminophylline is given
True | also when cetirizine or hydroxyzine given
27
T/F | Sorbic acid is found in foods such as strawberries, sweets, margarine and cheeses
True | can cause systemic contact dermatitis if contact allergy to sorbic acid
28
T/F | marinated fish products, jams and jellies, pickles and preserves contain parabens
True | can cause systemic contact dermatitis if contact allergy to parabens
29
T/F | Contact sensitization to propylene glycol can result in systemic contact dermatitis when antihypertensives are given
False | antihistamines
30
What are the top causes of eyelid dermatitis?
Atopic Seborrhoeic ACD esp nail varnish/acrylics, fragrance, make up, rubber, eye drops
31
T/F | Eczema craquele only occurs on the legs
False Mainly on legs esp shins but can be arms and hands, lower flanks or posterior axillary line can generalize
32
What are ‘parchment pulps’
dry and cracked fingertip pulps – maintain a depression after pressing
33
T/F | Discoid eczema can complicate Eczema craquele
True
34
T/F | Eczema craquele is not itchy
False | very itchy esp at night
35
What is the treatment of Eczema craquele?
soap free wash BD greasy emollient (paraffin, petrolatum, lanolin, ceramide or urea) may need weak-mod TCS to settle any inflammation May need to reduce heat and increase humidity at home Avoid long or hot baths
36
T/F | Chronic superficial scaly dermatitis is a prelymphomatous eruption
False | Thought to be abortive type of CTCL esp if clonal lymphocytic infiltrate
37
Whta is the difference if any between Chronic superficial scaly dermatitis and prelymphomatous eruption
Prelymphomatous eruption can look very similar but has finer scale, more angulated patches and is more itchy Also histo shows spongiosis and minimal infiltrate in benign Chronic superficial scaly dermatitis but is more towards MF in prelymphoma eruption If develop atrophy or reticulate pigmentation reclassify as ‘prelymphomatous poikiloderma’
38
T/F | Chronic superficial scaly dermatitis is the same as Small plaque parapsoriasis and digitate dermatosis
True | Digitate dermatosis is a variant which presents as elongated finger-like patches symmetrically distributed on flanks
39
T/F | Patches of Chronic superficial scaly dermatitis measure less than 5cm in diameter
True | except in digitate dermatosis
40
What is the natural history of Chronic superficial scaly dermatitis? what is the treatment?
Persist for years or decades Resistant to sustained remission Risk of progression to MF is from zero to May transform to prelymphomatous eruption with an increased risk of progression to MF treat with emollients, TCS, UVB
41
T/F | symmetrical rash on borders of fingers is a characteristic dermatophytide reaction to tinea pedis
True
42
T/F | dermatophytide persists even when the fungus is treated
False | resolves
43
T/F | dermatophytide can cause other reactions than eczema at distant sites
``` True - but v rare Pit rosea EN EAC urticaria erythroderma ```
44
T/F | Patients with discoid eczema often have some more typical eczema elsewhere
True
45
T/F | Patients with discoid eczema always have a history of atopic dermatitis
False | often do but not always
46
T/F | Discoid eczema is rarely itchy
False | very itchy
47
T/F | Discoid eczema can look annular
True
48
T/F | Discoid eczema can resemble HSV
True | can be group of vsicles on erythematous base
49
T/F | Discoid eczema of the hands affects the palms resembling pompholyx
False | discoid hand eczema affects dorsa and fingers
50
T/F | Discoid eczema is symmetrical
True | Often unilateral initially and then develop mirror image lesions on other side after some time
51
T/F | Discoid eczema may be triggered by staph aureus colonization of eczema
True
52
T/F | Discoid eczema can koebnerize
True
53
What are some triggers for discoid eczema?
``` staph aureus colonization of eczema depilating creams aloe vera mercury systemic drugs - methyldopa, gold think of 'Gold coins' ```
54
T/F | Discoid eczema affects children or older adults
True | kids often have AD
55
T/F | Discoid eczema is prone to superinfection and is often resistant to treatment
True
56
Discoid eczema treatment ladder?
General measures Rule out drug trigger BetC or BOZ+C good Betnovate in coal tar also useful for chronic treatment Infective flares may need antibiotics – erythro recommended in Rook Patch test in resistant cases For resistant cases – oral pred, other immunosuppressents UVB, PUVA
57
What is Sulzberger-Garbe disease?
= Exudative discoid and lichenoid chronic dermatosis or Oid-Oid disease Variant of discoid eczema Widespread eruption Mainly affects adult jewish men age 40-60 Unknown aetiology Discoid lesions with both exudative and lichenified (not lichenoid) phases which occur alternately or together Can be accompanying scattered round urticated lesions Very itchy Penile and scrotal lesions are common and pathognomonic; also most persistent Can blood eosinophilia or gynaecomastia Treatment resistant Can use oral pred or AZA Runs chronic course for months or years then resolves
58
T/F | Sulzberger-Garbe disease is discoid and lichenoid
False | discoid and lichenified not lichenoid
59
T/F | Penile and scrotal lesions are common and pathognomonic of Sulzberger-Garbe disease
True
60
T/F | Blasckitis is a rare, spontaneously reslving eczematous eruption in a blasckoid distribution in adults
True
61
T/F | Hand dermatitis is twice as common in men
False | twice as common in women
62
T/F | Hand dermatitis affects 2-5% population at any one time
True
63
T/F | AI Progesterone dermatitis can present as Hand dermatitis
True | Including pompholyx
64
T/F | 10% of adults with eczema have some component of hand dermatitis
False | 60%
65
T/F | Atopic hand eczema has the worst prognosis of all hand eczema types
True
66
What are the aetiological types of hand dermatitis?
Usually multifactorial Endogenous causes; o Idiopathic o Dyshidrotic – exacerbated by excess sweating o Progesterone dermatitis o Atopic Exogenous causes o Irritant contact Chemical – soaps, detergents, solvents Physical - friction, minor trauma, cold air, dry environment o Allergic contact Delayed hypersensitivity (type 4) – e.g. chromium, rubber, epoxy glues Immediate hypersensitivity (type 1) - latex, seafood o Ingested allergens - systemic contact dermatitis o Infection - exacerbates o Secondary dissemination – autoeczematisation or Id reaction
67
T/F | Most cases of hand dermatitis have arecognisable morphological type
False Most hand dermatitis is patchy and vesiculosquamous 1/3 has a recognisable morphological variant
68
What are the morphological types of hand dermatitis?
``` Apron eczema Chronic acral dermatitis Discoid eczema Fingertip eczema ‘gut’ eczema Hyperkeratotic palmar eczema Pompholyx Ring eczema Keratolysis exfoliativa (Recurrent focal palmar peeling) Wear & tear dermatitis Contact urticaria Others ```
69
T/F | Apron eczema type of hand dermatitis is usually due to ACD
False | Can be irritant, allergic or endogenous
70
T/F | Chronic acral dermatitis involves High IgE but no Hx of atopy
True
71
T/F | Chronic acral dermatitis responds well to TCS
False poor response to TCS responds to pred
72
T/F | Chronic acral dermatitis Is a hyperkeratotic papulovesicular eczema of hands and feet
True
73
T/F | Fingertip eczema involving most fingers on dominant hand is usually due to allergic contact dermatitis
False | this pattern is usually cumulative irritant dermatitis - soaps and trauma
74
T/F | Fingertip eczema involving first 3 digits on either hand is usually occupational
True Can be irritant or allergic Often dominant hand but may be non-dominant if due to foods e.g. onion, garlic Patch test often positive
75
T/F | Gut eczema starts in web spaces and spreads down sides of fingers
True | Due to contact with entrails in slaughterhouses esp pigs
76
T/F | Hyperkeratotic palmar eczema mainly affetcts young men
False | middle aged or older men are main sufferers
77
T/F | Hyperkeratotic palmar eczema can look alot like psoriasis
True
78
T/F | Hyperkeratotic palmar eczema is often resistant to treatment
``` True TCS Crude coal tar Salicylic acid PUVA Grenz rays ```
79
T/F | Keratolysis exfoliativa can be precursor of pompholyx
True
80
T/F | In ring eczema the pt usually patch tests positive to metals in the ring
False Usually negative ?due to build up of soap etc under ring and microtrauma
81
T/F | Asteatotic hand eczema is usually due to a genetic defect
False = wear and tear eczema Combination irritant dermatitis, asteatosis and microtrauma Often seen in cleaners and housewives Can be co-exisiting fingertip or ring eczemas Skin is dry and red with superficial white cracks criss-crossing surface
82
T/F | Asteatotic hand eczema is the dame as dyshidrotic hand eczema
False Asteatotic is very dry, wear and tear eczema Dyshidrotic eczema is pompholyx
83
T/F | dyshidrotic hand eczema is due ti abnormality of the eccribe sweat glands
False | although 'dyshydrotic' means abnormal sweat there is no proven connection with sweat gland activity
84
T/F | Pompholyx accounts for 5-20% of hand eczema cases
True
85
T/F | Pompholyx is an endogenous eczema and is idiopathic
False Its a clinical pattern of eczema but aetiology can vary May be endogenous or exogenous
86
What are the causes of pompholyx?
Atopy 50% ACD esp to PPD, benzoisothiazolinones, dichromates, perfume/fragrance, balsam of Peru Autoimmune progesterone dermatitis Autoecematization of a primary ACD of the feet Id rcn - dermatophytide or bacteride Drug eruption – aspirin, OCP, IVIg Systemic contact-type dermatitis esp to neomycin ingestion in pts with leg ulcers previously treated with topical neomycin
87
T/F | Cigarette smoking increases risk of Pompholyx
True
88
T/F | Pompholyx is primarily a bullous disease
False | vesicular but can get bullae as skin is thick allowing vesicles to enlarge
89
T/F | Pompholyx classically is crops of vesicles on an erythematous base
False | erythema usually not a feature
90
T/F | In Pompholyx 50% of cases involve hand and feet
``` False 80% palms only 10% soles only 10% both nearly always symmetrical; if asymmetrical think of contact derm ```
91
T/F | Pompholyx classically desquamates then resolves in 2-3 weeks and recurs at varying intervals
True | Some people prefer the term chronic vesicular dermatitis if it continues and doesn’t resolve and recur periodically
92
T/F | Pompholyx is always confined to the palmar or plantar surfaces
False can spread to dorsa of hands and fingers and can involve nails; Dystrophy, transverse pitting and ridging, thickening or discolouration
93
What is the prognosis of pompholyx?
1/3 don’t recur 1/3 recur 1/3 chronic course
94
What is the approach to investigation of pompholyx?
Careful Hx for contact allergens, food, medicaments and regularity of flares Examine feet/legs for tinea and elsewhere for bacterial and dermatophyte infections Should patch test all cases
95
T/F | Chronic continuous cases of Pompholyx can become hyperkeratotic
True | coal tar + steroid good
96
What is the approach to treatment of pompholyx?
``` General hand dermatitis measures In acute phase; o Rest hands and/or feet from use o Soak 3-4x per day in Condys crystals o Aspirate large bullae o Zinc cream Then start potent TCS in subacute phase Consider need for oral pred Low dose MTX or XRT for refractory cases antibiotics if infected coal tar + TCS if hyperkeratotic ```
97
T/F | Dermatophyte, Psoriasis and autoimmune blistering disease should be considered in the differentials for Pompholyx
True | BP, linear IgA disease, Pemph gestationis, paraneoplastic pemphigus, anti-p200 pemphigoid
98
T/F | Smokers have worse occupational hand eczema than non-smokers
True
99
T/F | Smokers hand eczema readily responds to treatment
False | more likely to be resistant
100
T/F | Smokers miss more work time due to hand dermatitis and are more likely to become unemployed
True
101
T/F | Men are more likely to suffer occupational consequences of hand eczema than women
False | women more likely
102
Which factors predict poor prognosis in hand dermatitis
atopic dermatitis widespread eczema severe disease at presentation frequnt flares
103
T/F | acrylates and epoxy resins can penetrate vinyl and rubber gloves
True
104
What is Rx ladder for hand dermatitis?
``` Full exam and work up - exclude DDs Usually patch test Rest hands stop smoking Avoid soap and irritants and friction Condys soaks Emollient++ Gloves for hand work potent TCS +/- occlusion Topical tacrolimus Resistant patches may need ILCS Tar on non responding chronic cases e.g. 5% crude coal tar Sal acid if hyperkeratotic PUVA – systemic or topical UVB Superficial Xrays – pt can safely have 3 course of 3Gy of superficial Xrays in their lifetime Alitretinoin - not in Aus Acitretin sometimes useful CsA Can use Zinc paste or Friars balsam to seal fissures Treat infected flares with antibiotics For resistant cases consider metal in diet causing systemic contact dermatitis – can use oral chelating agent ```
105
T/F | In hairdressers, localized interdigital dermatitis is a precursor for hand dermatitis
True
106
T/F | hand dermatitis can resolve quickly if an avoidable causative contact allergen is identified
True
107
T/F | Infective eczema clears when the triggering infection is treated
True
108
T/F | Raised CRP can help differentiate infected from colonized eczema
True
109
T/F | neuts, microvesicles and subcorneal pustules can be a feature of infective eczema
True
110
T/F | Infective eczema caused by staph or strep is associated with HTLV-1
True | this is a particualr type mainly seen in afro-caribean kids
111
T/F | Juvenile plantar dermatosis affects girls more than boys
False boys more esp age 3-13
112
T/F | Juvenile plantar dermatosis is more common in kids with atopy
False | but in atopic kids the hands may be affected
113
T/F | Juvenile plantar dermatosis affects the weigh beairng parts of the feet
True
114
T/F | Histo of Juvenile plantar dermatosis shows a severe spongiotic dermatitis
False usually mild may show blocked sweat ducts
115
What are the main DDs of Juvenile plantar dermatosis?
ACD | moccasin tinea pedis
116
What are the treatments for Juvenile plantar dermatosis?
Usually clears spontaneously Wear cotton socks and leather shoes, avoid non-porous footwear WSP, tar, urea, Lassar’s paste (sal acid in zinc paste)
117
T/F | Juvenile plantar dermatosis can persist into adulthood
True | but rare
118
What is dermatogenic enteropathy?
malabsorption due to severe eczematous inflammatory skin disease
119
What are the causes of photosensitive eczemas?
``` Hot (sun) CHIP Carcinoid syndrome Hartnup disease Isoniazid Pellagra ```
120
What is Meyerson’s naevus / Meyerson’s phenomenon
Halo of dermatitis around a naevus or other benign lesion • Resolves spontaneously in few months • Naevus remains
121
T/F | Pityriasis alba always presents with other features of atopic dermatitis
False
122
T/F | Pityriasis alba clears in 3-4 months
False | Often last many months, on face often over a year
123
T/F | Erythema and scale may be features of Pityriasis alba
True | often precede hypopigmentation and may persist
124
What are the associations of Seborrhoeic dermatitis?
Parkinsons HIV (1/3 of HIV pts) mood disorders NB Can improve with levadopa Rx in Parkinson’s
125
T/F | Sebum excretion is increased in seb derm
False | normal in males and reduced in females
126
T/F | Seborrhoeic dermatitis can extend beyond scalp margins onto forehead
True | = ‘corona seborrhoeica’
127
T/F | Seborrhoeic dermatitis Can cause otitis externa or blepharitis
True
128
T/F | Seborrhoeic dermatitis can form annular lesions
True | Petaloid seb derm - small annular areas close to each other
129
T/F | Severe persistant scalp seb derm can cause non-scarring alopecia
True
130
T/F | Seborrhoeic dermatitis cannot generalise
False Some get a generalised erythrosquamous eruption which is typically pityriasiform but more extensive than pit rosea can cause erythroderma
131
T/F | Seborrhoeic dermatitis at genital sites can be same as elsewhere, red with minimal scale or more psoriasiform
True
132
T/F | Seborrhoeic dermatitis always worsens in sun
False | often flares it initially then later sun may help
133
T/F | Seborrhoeic dermatitis and rosacea together is common
True
134
T/F | Seborrhoeic dermatitis in HIV has more follicular involvement and more plasma cells + more malassezia
True
135
T/F | What are main histo features of Seborrhoeic dermatitis?
SNP - sullivan Nics pathology Spongiosis - mild may be Neuts in horn Parakeratosis ‘lipping’ the edges of follicles Little or no parakeratosis in between follicles
136
T/F | Washing with soap is recommended in seb derm
True | malassezia live on sebum (lipids) - soap best to get rid of this
137
What is treatment ladder for seb derm?
``` Pt education - chronicity Wash BD with soap and water Azole antifungals +/- weak-mod TCS weak tar or sulphur can help; - 2% LPC cream - 3% sulphur +/- 3% salacid cream TCNI if requiring frequent TCS oral terbinafine or itraconazole if resistant Pred low dose if severe/generalized Scalp; Azole (ketoconazole 2%), selenium sulphide, zinc pyrithione or tar shampoos 5% sal acid for severe scalp involvement ```
138
What organism is responsible for Pityrosporum folliculitis?
malassezia Spp. In yeast form only - no hyphae Usually M. furfur but also globosa
139
In whom is Pityrosporum folliculitis most common? | What are risk factors?
``` women slightly more than men Down's syndrome Immunosuppressed, diabtes after antobiotics esp doxy pts with acne pregnancy, OCP stress ```
140
T/F Pityrosporum folliculitis affects the upper trunk with itchy follicular papules and pustules which look like acne except no comedones, cysts or scars
True
141
What are DDs of Pityrosporum folliculitis?
steroid folliculitis | acne
142
T/F | Pityrosporum folliculitis usually responds to azole creams
True - but often recurs apply twice a week for 4 wks. Wash off after 15 mins rare cases need oral itraconazole 200mg/day for 1 week Nb Dont use terbinafine or griseo - not effective regular azole cream, shampoo etc may allow longer remission
143
T/F | Venous eczema only occurs if there is increased venous pressure
True
144
T/F | Lateral malleolus is the classic starting point of Venous eczema
False | medial malleolus
145
T/F | Venous eczema can have a sudden onset
True
146
T/F | Venous eczema only affects the legs
False can occur in fatty pannus of obese abdomen or around AV fistula site Other leg can develop autoeczematisation even if not involved primarily Can be generalized eczematisation, can be erythroderma
147
T/F | Venous eczema has highe rate of secondary infection and medicament ACD
True
148
T/F | For infected stasis eczema topical antiseptics +/- systemic antibitoics are preferred to topical antibiotics
True
149
What are the features of post thrombotic limb/ deep venous insufficiency ?
varicose veins, dilated superficial veins, (woody) oedema, purpura, haemosiderin, ulceration, telys, atrophie blanche, lipodermatosclerosis
150
What is Prurigo Pigmentosa?
Rare eruption of Itchy red papules on trunk and neck, can be vesicles Affects adult females in spring and summer esp in japan; rare in western world Lesions coalesce and turn into reticular erythema and then hyperpigmentation Unknown cause. Pts may have diabetes or anorexia Can have blood eosinophilia Treat with minocycline 200mg/day or erythromycin
151
T/F | The incidence of atopic dermatitis in the western world is about 2%
False | 10%
152
T/F | Elevated IgE is found in nearly all cases of atopic dermatitis
F 80% of atopics have high IgE, 20% normal 50% of infants with eczema have normal IgE but only 5% of adults 15% of normal people have high IgE
153
T/F | Sensitvity to M furfur may play a role in atopic dermatitis restricted to the face
True Look for Malassezia specific IgE on RAST/positive skin prick to Malasseza components – if so, try oral anti-fungal (itraconazole)
154
T/F | Spongiosis is an important feature of chrinic atopic dermatitis
False spong more in acute Psoriasiform hyperplasia is most important finding in subacute and chronic eczema
155
T/F | The dirty neck seen in atopics is due to melanin incontinence
True | reticulate pigmentation due to longstanding eczema
156
What is Hertoghe sign?
thin/absent lateral eyebrows in stopic dermatitis
157
T/F | Most cases of infantile atopic dermatitis are present at birth
False | onset is rarely prior to age 2 months
158
T/F | Involvement of the napkin area is common in atopic dermatitis
False | rare
159
T/F | In infants the face is often first site involved in atopic dermatitis
True
160
T/F | Follicular lichenified papules can be seen as a feature of atopic dermatitis in asian and dark skinned children
True
161
T/F | In adults genital and nipple pruritus can be a feature of atopic dermatitis
True
162
T/F | Hand involvement is rare in children with atopic dermatitis
False A patchy, vesicular and somewhat licheniifed eczema of the hands is a common manifestation of atopic dermatitis in childhood
163
T/F | In atopics the risk of anaphylactic drug reactions is increased
True
164
T/F | In atopics the risk of non-type 1 drug reactions is increased
False
165
T/F | Dennie-Morgan infraorbital folds are specific for atopic dermatitis
False | non specific
166
T/F | The incidence of cataracts is increased in atopic dermatitis
True | Uncommon overall but up to 10% of severe AD pts
167
T/F | In up to 80-90% of individuals the onset of atopic dermatitis is prior to 5 years of age
True
168
T/F | Atopic dermatitis shows little tendency to improve during childhood
False improves during childhood but may relapse at adolesence 50-80% clearance within 20 years
169
T/F | The recommended concentration of topical tacrolimus for children is 0.1%
False 0.03% for children if over age 2 years Use 0.1% for adults Pimecrolimus (1%) for children over 3 months
170
T/F | Breast feeding reduces the risk of atopic dermatitis
True Or possibly true - evidence that it may do Also; Early avoidance (first 6 mths) of food (milk, soy, peanuts, wheat, fish) and aero allergens may prevent developing allergy Extensively hydrolysed cows milk formula rather than cows milk or soy formulas Pro or pre -biotics for preg mum or child up to age 4 may also help reduce AD development
171
T/F | Non atopics make IgG to housedustmite but atopics make IgE
True
172
T/F | If pt has eczema alone IgE may not be that high but usually very high if asthma and/or hayfever
True | Raised IgE is a marker of atopy
173
T/F | Many AD pts have IgE mediated allergy to components of their own sweat
True
174
What are intrinsic and extrinsic eczema?
Eczema with raised serum IgE has been called extrinsic atopic dermatitis whereas eczema with normal IgE sometimes called intrinsic eczema/AD not recommended terminology
175
T/F | The skin of pts with eczema has reduced defense against staph, malasezzia and herpes virus
True may be due to imbalance in favour of Th2 T-helper profile alos at increased risk of; HPV warts, vaccinia, coxsackie A, molluscum and fungal infection
176
T/F | eczema pts are prone to vasoconstriction of small skin vesssels resulting in cold extremeties and white dermatographism
True
177
T/F | Sedating anthistamines mainly help eczema by reducing pruritus
False mainly by sedation But mast cells and histamine do play a role in eczema
178
T/F | The itch of atopic derm responds quickly to cyclosporin
True
179
T/F Targeting the histamine HR4 receptor in addition to the HR1 receptor and targeting IL-31 may be future strategies to reduce histamine-related itch in AD
True
180
T/F | Low but not high vitamin D increases suceptibility to eczema
False | both low and high vitamin D increases suceptibility to eczema
181
T/F | Normal skin has a slightly basic pH
False slightly acidic (pH 5) due to natural moisturizing factor eczema skin is more basic than normal skin - pH 6
182
T/F | Both soap and bleach are alkali and hence can worsen eczema
True | avoid soap and keep bleach baths short
183
T/F | AD skin has reduced ceramides
True | esp ceramides 1 and 3
184
What are the patho-aetiological factors in eczema?
``` B-SIMVA (BJD paper 2014) Barrier dysfunction Staph colonization Immune dysregulation Mast cell histamine release Vitamin D derangement Abnormal vascular responses ```
185
What is the sequence of the atopic march?
Eczema - peaks age 1-2 Asthma - peaks age 5-6 Hayfever - peaks early in second decade NB food alergy peaks age 1-2 and often resolves before age 5
186
T/F | There is evidence that aggressive control of eczema may somewhat mitigate the progress of the atopic march
True
187
T/F | anaphylactic drug reactions are more common in atopics
True
188
T/F | Protein contact urticaria is rare in atopic dermatitis pts
False | quite common
189
T/F | one quarter of infants with seb derm go on to develop eczema
True
190
T/F | Hand dermatitis affects >50% of adults with AD
True | 60%
191
T/F | AIDS can trigger eczema 'recall' in soemone who previously outgrew their AD
True
192
T/F | 50% of eczema pts have icthyosis vulgaris and 15% of icthyosis vulgaris pts have eczema
False | other way around
193
T/F | Adult AD pts are at increased risk of fractures
True
194
T/F | AD causes increased skin cancer risk
False | no increase in skin or internal cancers
195
What are the associations of atopic dermatitis?
``` Atopy - asthma, food allergy, hayfever Alopecia areata Hand dermatitis (inc w/ age) Icthyosis vulgaris Keratosis Pilaris Eye problems - cataract, keratoconus Fractures (adults only) Contact urticaria In kids - depression, anxiety, ADHD ```
196
T/F | atopic derm pts ofetn get keratosis pilaris in the absence of icthyosis vulgaris
True 40% of AD pts get KP kids get it on cheeks
197
What are the diagnostic criteria for atopic dermatitis?
Modified UK criteria; 'Itch Only Involves His Visibly Dry Areas' Itchy rash + at least 3 out of 5 of; Onset before age 2 Involves skin flexures or cheeks if under 10 yrs on History Visible involvement of flexures or cheeks/forehead/extensors if under 4 Dry skin in last year Asthma or hayfever or atopy in Pt or 1st degree relative before age 4
198
T/F | AD typically starts after 2 months and before one year
True | 60% in first one year, 90% before age 5
199
What are triggers of eczema flare ups?
``` Infection stress/habitual scratching Sweating (thermal or emotional) Wool (and sometimes other) fabrics Water/ chlorinated water Dry weather Sand Can flare pre-menstrually In pregnancy – 50% flare, 25% no change, 25% improve ```
200
T/F | AD often flares in pregnancy
True | 50% flare, 25% no change, 25% improve
201
T/F | Thick scaly scalp/cradle cap after 2 months of age is AD rather than seb derm
True
202
T/F | Infantile AD often involves nappy area
False | usually spared
203
T/F | Asian and black infants may retain extensor distribution eczema until older than caucasian kids
True
204
In addition to eczema kids often have pit alba, lip-licking eczema /upper lip cheilitis, hand dermatitis and juvenile plantar dermatosis
True
205
AD pts may have Icthyosis, KP and hyperlinear palms but not necessarily have icthyosis vulgaris
True | can all occur in AD alone
206
Asian and black kids often get micropapular eczema variant with hypo or hyper pigmentation – lesions are often folliculocentric – look like goosebumps
True | AKA Patchy pityriasiform lichenoid eruption or follicular atopic dermatitis
207
What is ‘atopic red face’?
Adult AD pts with primary facial dermatitis often severe around eyelids
208
What is Hertoghe sign?
thin/absent lateral eyebrows in eczema
209
What is dirty neck?
reticulate pigmentation due to longstanding eczema
210
How may eyes/eye region be affected in eczema?
Conjunctivitis, keratoconus ‘atopic red face’ eyelid only eczema - ichenification is characteristic Orbital darkening/Panda eyes – grey-brown-violet skin around eyes. Often pale elsewhere Dennie-Morgan infraorbital folds Blepharitis
211
What are Dennie-Morgan infraorbital folds?
Start at or near inner canthus, extend ½ to 2/3 width of eye | single or double
212
T/F | nails are usually spared in adult hand dermatitis
True | kids more vesicular and more likely nail involvement – coarse pits and ridges
213
T/F | Half of pts with atopic hand eczema also have foot involvement
True
214
How do your test an eczematous child for potential immunodeficiency?
Immunoglobulin levels and subclasses, total IgE level, FBC, complement profile & function, Tcell, Bcell and phagocyte cell numbers and function tests. Consider also HIV and/or HTLV-1 testing
215
T/F both RAST and skin prick tests have low specificity and positive predictive value (about 50%) but high sensitivty/negative predictive value (>95%)
True | good rule out tests
216
T/F | severity scoring systems are useful in rotione eczema practice
``` False JAAD says not useful NICE says classify as mild/mod/severe e.g. Diepgen SCORAD – Scoring atopic dermatitis EASI – Eczema area scoring index Rajka & Langeland score Nottingham score ```
217
T/F | Children with eczema often clear by teens
``` True 50% clear by teens many clear by school age Overall; 50% clear in about 10 years and 85% clear in up to 20 years ```
218
What are the features of Atopic keratoconjunctivitis?
JAAD paper on this 2014 Chronic (not seasonal) itching, watering, burning pain, blurred vision Most severe ocular complication – can cause blindness Suspect esp if eyelid/periorbital eczema, look for red eyes Urgent ophthal referral - see within days
219
What are the eye complications of eczema?
Blepharitis - common if eyelid AD Cataracts Atopic keratoconjunctivitis Vernal keratoconjunctivitis (cobblestone papillae on upper palpebral conjunctivae) Keratoconus (conical cornea) – rare, can be assoc w/ AD Retinal detachment (rare)
220
T/F | stress-responders are pts whose eczema flares when they are stressed
True | 'no-stress responders’ have no association between stress and disease course
221
What are the complications of eczema?
Psychological - family dysfunction, school/work problems, relationship problems, social stigma, mental health problesm Financial - v costly QoL - impaired for pt and caregivers Skin - infection, lichenification, prurigo nods, dyspigmentation, erythroderma, hand dermatitis, topical or systemic steroid AEs Eyes - several Systemic - sleep disturbance, irritability, poor concentration, growth delay Other drug AEs including those from alternative medicines
222
T/F Psychoneuroimmunology is the interaction between nervous and immune systems by hormones, neuropeptides and neurotransmitters
True | a brain-skin connection underlies many inflammatory dermatosis
223
T/F | Stress responses can stimulate mast cell activation
True
224
T/F | AD patients may have a blunted production of cortisol so that CRH release is not switched off by negative feedback
True
225
T/F Stress causes increase endogenous glucocorticoids and reduced lipid synthesis and impairs skin barrier function leading to flares of AD or other skin disease
True
226
T/F | high perceived stress levels have no effect on barrier recovery rates
False | cause delayed barrier recovery rates
227
T/F | >90% of AD pts experienced itch at least once a day
True 70% do 5x per day may experience their itch as heat or pain
228
T/F | In AD levels of depression, anxiety and suicidal ideation correlate with disease severity
False | levels are higher than normal but dont corelate with severity
229
T/F The impact of AD on health related QoL is same as arthritis, diabetes, heart disease, depression or if severe the same as CF or renal disease
True
230
T/F | adults with AD have lower libido
True
231
T/F | It is important to to assess pts mental state and QoL during the consultation for AD
True
232
What info is important to provide at first diagnosis of atopic dermatitis?
Explain diagnosis - written info Must explain chronicity - need to manage; cant cure Prognosis - tends to improve Associations esp atopic march Usually not diet related but may have food allergies also advise on triggers and irritants Establish short and long term goals of treatment provide written management plan inc managing flares info on dose and frequency of Rx, how to step up or down advise on recognistion of infection where to find further info/ get support
233
What is Therapeutic Patient Education (TPE)?
Educational strategy for pts/carers Delivered by MDT For pts with little social support or failed treatment Tailored to pts educational and cultural background 4 steps; - Understand pts current knowledge, beliefs etc - Determine educational objectives with the pt - Help pt/carer to acquire knowledge and skills – wide range of tools/resources used - Assess the TPE process Good evidence for improved disease control and QoL esp for interventions lasting >30 mins
234
T/F | Demonstrating how to apply topicals and wet wraps improves compliance and disease control
True
235
How do you do ‘soak and smear’? | AJD, 2015
Apply compress of lukewarm tap or bathwater to area for 10-20 mins then apply TCS
236
T/F | ‘soak and smear’ is a useful alternative to wet dressings
True
237
T/F | In eczema pts after a bath topical steroid or emollient should be applied within 10 minutes of drying
False | within 30 minutes max but ideal is within 3-5 minutes
238
T/F | using TCS in evening with emollient in morning can as effective as BD steroid
True
239
Which steroids are more suitable for children under age 1?
Usually moderate and/or mild potency but may need potent Elocon and advantan/AFO have increased cutaneous metabolism so less systemic bioavailability so better for kids (as have high rates of systemic absorption)
240
T/F | cling film occlusion is a useful technique in eczema
False | use wet dressings for occlusion NOT cling film
241
T/F | can leave wet wraps on for 24 hrs
True Fine if tolerated Usually used for up to 12 hrs often left on overnight
242
What are the side effects of topical steroids?
Irritation and stinging (esp creams & gels or if contain alcohol or propylene glycol) Skin atrophy, with striae, visible veins and easy bruising Erythema and telangiectasia Periorificial dermatitis/ steroid acne Masking of infection esp tinea If applied to eyelids; glaucoma, cataracts Systemic steroid effects and HPA axis suppression
243
What is TCS withdrawal? | JAAD Hajar et al 2015
Skin eruption which can occur after using TCS daily. Usually mod or strong potency, rare in mild TCS Occurs on ceasing TCS or during TCS use and required increase use/strength to prevent it Well demarcated erythema with burning/stinging Half of pts get papules/nodules/pustules 2 broad subtypes - about half of all pts in each subtype; - Papulopustular subtype – erythema, papules, pustules – often TCS used for cosmetic reason or acneiform disorder - Erythematoedematous subtype – burning erythema and oedema – often TCS used for eczema or seb derm May be itch, pain, hot flushes and exacerbations with sunlight or heat
244
T/F | Most pts with steroid addiction/withdrawal have positive patch tests to a topical they are using
False 15% do may be the TCS or another topical
245
How do you manage TCS withdrawal?
stop steroids supportive cares – cold compresses, consider antibiotics if papular Consider APT consider a weaker TCS which the pt has not had a positive patch test to in order to wean off
246
T/F | topical calcineurin inhibitors increase risk of skin cancer
False | No proven risk of lymphoma or skin cancer
247
How do you prepare a bleach bath?
White King bleach 4%, 12mls in 10L warm water (not hot) - fill bath with 10L bucket first time and mark level bath for up to 15 mins Can add 100g pool salt per 10L and/or 1-2 capfuls of oil per bath RCH Melbourne advise; daily for one month; 3x/wk for 1 month; weekly for 1 month
248
Are topical antimicorbials useful in eczema?
Fucidic acid and bactroban not of use except nasal bactroban for eradication (Rook) Mupirocin can be used alone in localized infections (BJD, 2014) Clioquinol useful - can use with TCS; Hydroform or compounded
249
T/F | You should rinse off the bleach after a bleach bath
False | do not rinse
250
What are some trigers to avoid in eczema?
Mechanical – rough textiles, wood Physical – car exhaust, tobacco smoke Biological – pets, HDM, pollen, microbes Chemical – acids, alcohol, solvents, bleaches, some foods/additives, vasoactive amines
251
T/F | emollients alone can settle acute eczema
False Emollients can irritate acutely inflamed skin and increase risk of infections - settle acute flare before suing emollient
252
T/F | Potent or superpotent TCS cream is mainstay for (wet) acute eczema flares
True Some pts w/ very acutely inflamed lesions will not tolerate TCS alone and need wet wrap therapy with potent TCS cream for several days
253
What is 'proactive' or 'hot spot' Rx? why is it used?
Apply TCS or TCI twice a week to previously affected areas and emollient only to non-affected areas – results in reduced flare incidence and duration and improved QoL
254
T/F | tachyphylaxis occurs with antihistamines
True | take a break every 2 weeks
255
T/F | CsA is better tolerated in kids than adults
True ‘Drug of choice for refractory AD’ (BJD) In kids kids check BP and U&E every 2 weeks for first 3/12 then monthly
256
T/F | A 3-6 month course of CsA is often sufficient to gain control in kids with eczema
True Start at 3-5mg/kg/day (often 5) and wean down to lowest effective dose if acute, otherwise can start low and work dose up
257
T/F | CsA is 1st line for long term systemic in AD
False AZA 1st line if long term systemic needed Usually in kids about 2.5 mg/kg/day but up to 4 (higher than adults)
258
T/F | AZA causes photosensitivty
False | but increases risk of skin cancer so avoid sun
259
T/F | nbUVB in eczema uses same protocol as in psoriasis
True
260
Eczema is a stronger risk factor for food allergy than asthma
False | other way around
261
T/F | Food can aggravate eczema in 10-35% of young children
True | Food allergy may result from and aggravate eczema rather than ‘causing’ it
262
Which 6 foods account for >90% of childhood food allergies which can aggravate eczema?
``` Eggs (most often reported to flare AD) Milk Peanuts Soy Wheat Fish ```
263
T/F | Milk and soy allergies tend to persist
False (tree) nuts, fish and shellfish allergies tend to persist other resolve in childhood
264
When to test for food allergy in AD?
US JAAD guidelines – can consider limited food allergy testing to 6 highest risk foods if pt is under 5 and has mod-severe eczema and o Fails to clear despite optimized topical therapy; Or; o Reliable Hx of immediate allergic reaction after ingesting a specific food; Or; o Both of above
265
T/F In AD with food allergies if cows milk an issue try extensively hydrolysed formula or amino acid formula rather than soy as can also be allergic to soy
True
266
T/F | Strong evidence that breast feeding prevents eczema
False
267
What is the most important inhaled allergen for eczema?
Housedustmite antigen
268
T/F | TCS are the most common contact allergens in atopic dermatitis allergic contact dermatitis
False Most common are; Nickel, neomycin, fragrance, formaldehyde and other preservatives, lanolin and rubber chemicals
269
What is protein contact dermatitis? | what are the causes?
= contact urticaria Allergy to contact with plant or animal proteins causes initial urticaria within 30mins then a dermatitis like eczema which can be acute or chronic E.g. fruit/veg, grain, latex, meats, fish, mites, insects, nuts, spices/herbs, animal dander/hair/saliva/urine
270
T/F | probiotics help restore a normal skin microbiome in eczema
False no evidence of benefit It is unclear if gut microbiome impacts on skin microbiome
271
T/F | Evening primrose oil helps reduce itch in eczema
False | no evidence of benefit
272
T/F | consultations with dermo for eczema usually meet patients expectations
False data from UK; Only 19% of initial eczema consultations w/ dermatologist met pt expectations in UK Only 50% of pts satisfied with the treatment given
273
Why do eczema pts get por outcomes/ treatment failure?
AJD review paper Sokolova, 2015 (NSW); - Treatment regimes too complex and time consuming - Lack of understanding of what different topical are and when and how to use them - Health related QoL is impaired for both eczema kids and caregivers – negatively impacts on adherence - Patient/carer dissatisfaction – less likely to adhere if not involved in decision making - White coat compliance - Long follow up results in lower rates of compliance - Corticosteroid phobia – >80% of parents worried about effects of steroids - Use of complementary and alternative medicines
274
What steps should you take if eczema pt fails to respond?
Take Hx of triggers/ change in behaviours Check compliance and assess for steroid phobia assess for infection (and infestation) Consider an alternative or additional diagnosis; Irritant CD ACD Protein contact dermatitis Photo allergic contact, phytophoto, photo-drug etc Other – lupus, DH, MF, nutritional deficiency, immune deficiency Drug eruption Consider investigation - food diary, APT, RAST, skin prick Finally consider escalating Rx
275
What is ‘white coat compliance’ ?
medications (esp TCS) are used most around the time of clinic visits but rapidly drop off after opd until shortly before
276
T/F | Fibulin is the major gene mutation in eczema
False FLG gene which codes for fillagrin Different populations display different mutations at different frequencies = ‘ethnospecific profiles’
277
T/F | Bathing without subsequent emollient leads to dry skin
True
278
T/F | HPA axis suppression is highly unlikely in kids with eczema even with long use of TCS
False HPA axis suppression can occur quickly in children even with low or moderate strength TCS Try to keep courses to under 3 weeks acute flares need Rx for 1-2 weeks
279
What methods can be used to improve treatment adherence in AD?
Optimize relationship between Dr and patient/caregiver Education – can’t have too much! E.g. handouts, demonstration, nurse-led training sessions, videos, workshops Particular education about TCSs Written eczema action plan Encouragement strategies – sticker charts for kids, texts for teens etc Early and frequent follow up Emphasize improved QoL for whole family if better disease control is gained
280
What are the 5 Pillars of AD management?
Eczema is a 'Cycle RACE' 1. Tackling itch-scratch cycle 2. Rebuilding and maintaining optimal barrier function 3. Avoidance/modification of environmental triggers 4. Clearance of inflammatory skin disorders 5. Education and empowerment of Pt/caregiver
281
T/F | Moisturizers act as topical steroid sparers reducing need for TCS
True
282
T/F | Moisturizer and emollient mean the same thing
``` False Moisturizers have varyng amounts of these properties; Occlusive (prevent water loss) Humectant (trap moisture in SC) Emollient (lubricate) ```
283
How much moisturizer should be used in AD?
100-200g/wk in kids | 200-300g/wk in adults
284
T/F prescription emollient devices (PEDs) containing ceramides or filaggrin breakdown products are more effective than other moisturizers
False | no evidence for this
285
What is a fingertip unit?
‘amount of topical expressed from tube with a 5mm diameter nozzle from distal skin crease to tip of index finger of an adult’ covers the surface area of a hand (2 palms) is about 0.5g
286
How many FTUs are needed for the bosy in adults?
Entire body: about 40 units (20g) One hand: apply one fingertip unit One arm: apply three fingertip units One foot: apply two fingertip units One leg: apply six fingertip units Face and neck: apply 2.5 fingertip units Trunk, front & back: 14 fingertip units
287
T/F | Infected skin is a contraindication to TCS
False | No contraindication to TCS in infection but must treat infection
288
When are wet dressings most useful? | when are they not advisable?
Should be used during acute flares in mod-severe eczema with or without TCS Avoid or use with caution if any infection present
289
T/F | 50% of adult pts with eczema carry staph
False 90% carry staph In 90% of affected areas and 75% of uninvolved areas
290
T/F | there is controversy about the use of topical antibiotics and antimicrobials in eczema
True AsiaPacific committee doesn’t support topical antiseptics (bleach baths, triclosan, benzalkonium chloride, chlorhex) due to risk of irritation and removal of normal skin commensals JAAD supports bleach bath w/ intrnasal bactroban as eradication for pts with recurrent clinical staph infections Rook says never use bactroban except nasally BJD paper says bactroban can be used alone in localized infections
291
T/F | Phototherapy can be used in children over 12 years
True | not for kids under 12
292
T/F | Oral steroids are never useful in AD
False Short term oral steroids may be useful – up to 6 wks for acute flares Don’t use IV or IM steroids
293
What strategies may help Primary prevention of eczema in a baby?
early avoidance of food and aero allergens may prevent developing allergy ie) in first 6 months of life Early life exposure to endotoxins, farm animals and dogs may be protective Breast feeding recommended and may reduce AD, also extensively hydrolysed cows milk formula rather than cows milk or soy formulas Weak evidence that maternal avoidance of milk, eggs and other dietary allergens in pregnancy and lactation can reduce risk of eczema Pro or pre -biotics for preg mum or child up to age 4 may also help reduce AD development Early use of emollient can be protective
294
``` T/F Eczema herpeticum (Kaposi’s varicelliform eruption) is a more widespread skin involvement than would be seen on normal skin infected with same virus (usually HSV1) ```
True Most Herpes infections in eczema pts are localized and not more severe than in normal pts so should not be called KVE but often still called ‘eczema herpeticum’
295
T/F | Eczema herpeticum can be caused by primary or recurrent herpes infection
True | Primary infection more likely to cause malaise, fever and low lymphocyte count
296
What are the risk factors for Eczema herpeticum?
``` Age – most common in teens and 20s Early age of onset of AD High IgE Severe eczema and asthma Not linked to TCS or topical calcineurin inhibitors ```
297
T/F | Eczema herpeticum causes scarring
False
298
What are complications of Eczema herpeticum?
Rare progression to systemic infection – can be fatal herpes keratitis - must get ophthal consult if close to eyes meningoencephalitis
299
T/F | In Eczema herpeticum early initiation of antivirals reduces length of hospital admission
True
300
T/F | In Eczema herpeticum should use antivirals early and for at least 7 days
True IV if severe also swab for baceria most dermos give course of Abs empirically
301
T/F | should stop TCS in cases of Eczema herpeticum
False | can continue if on Rx for HSV and also for bacteria
302
Whats the incubation period for HSV/Eczema herpeticum?
about 10 days (5-20)
303
T/F | Immiquimod should be avoided in eczema pts with molluscum
False can use all treatments some may be iritating so try to keep off eczema skin
304
T/F | Malasezzia hypersensitivity can be a cause of treatment failure esp in pts with severe facial AD
True Test w/ skin prick to malasezzia extracts Rx w/ 2 weeks of oral itraconazole
305
Treatment ladder for atopic dermatitis
General measures - trigger avoidance, education, soap free wash Emollient - TDS, cream if acute, ung if subacute/chronic Anti-infectives as required TCS - BD or OD, up to 3 weeks; stenght depends on pt age and body site; formulation on acuteness; advantan and mometasone safer for infants soak and smear wet dressings (both emollient or TCS) TCNI - short course or as proactive Rx; esp if steroid AEs +/- sedating antihistamines prn short course Phototherapy - 2nd line if >12 years Systemics; pred - for up to 6 wks to gain control CsA - for up to 3-6 months AZA - 1st line for long term Rx - 1-2 yrs. 2.5-4mg/kg MMF - 2nd line; 25-50mg/kg/day in kids >2yrs MTX - 3rd line; 7.5-25mg weekly Rarely needed; monteleukas oral/topical sodium cromoglycate PDE4 inhibitors (Apremilast) IVIg; 0.5g/kg daily for 4 days each month for min 3/12 IFN gamma - last line Also consider and treat; ACD, food allergy, protein contact dermatitis, inhlaed aeroallergens esp HDM Rx associated depression, anxiety, ADHD Education and engagement of caregivers is paramount