Eczema Flashcards
What are the features of acute eczema?
Papulovesicular
Erythematous
Oedema (spongiosis)
Ooze or scaling and crusting
What are the features of chronic eczema?
Thickening
Elevated plaques
Increased scaling
How is an eczema rash described?
Itchy, ill-defined edges, erythematous and scaly
What is contact allergic dermatitis?
Allergen causes delayed type 4 hypersensitivity
What are examples of causes of contact allergic dermatitis?
Chemicals
Topical therapies
Nickel
Plants
What is the immunopathology of contact allergic dermatitis?
Langerhans cells in epidermis process antigen then present to Th cells
Sensitised Th cells migrate to lymphatics and lymph nodes
On subsequent antigen challenge specifically sensitised T cells proliferate, migrate to, and infiltrate skin
What is seen in histology of contact allergic dermatitis?
Inflammatory infiltrate
Spongiosis - intercellular oedema
How is diagnosis done for contact allergic dermatitis?
Specific substances can be identified by patch testing
What is contact irritant dermatitis?
Non-specific physical irritation rather than a specific allergic reaction
What are examples of causes of contact irritant dermatitis?
Soap
Detergent
Cleaning products
What is the presentation of contact irritant dermatitis?
Erythema Scale Fissures Lichenification Nail dystrophy Crusting
What are the clinical features of atopic eczema?
Pruritis
Ill-defined erythema and scaling
Generalised dry skin
Flexural distribution
What is atopic eczema associated with?
Asthma
Allergic rhinitis
Food allergy
What is eczema herpeticum?
Eczema caused by herpes simplex virus
What is the presentation of eczema herpeticum?
Monomorphic punched-out lesions which look like cold sores Itching Flexural rash Dry skin Usually under age 2