ECT Flashcards
ECT disproportionately increases ____ and ____ in anterior cingulate cortex, the generator of ____
metabolism and blood flow
Theta rhythms
____ receptors in postsynaptic neurons sensitized by repeated ECT
5Ht3 and 5HT1a
ECT also increases release of ___ and _____ from locus coeruleus and substantia nigra
noradrenaline and dopamine
Indications of ECT
Medication-resistant severe depression (especially with delusions/suicidal ideations), acute mania or catatonia not compliant with meds, acute psychosis with schizophrenia,
Contraindications to ECT
Respiratory infection, MI/CVA within 6 months, uncontrolled BP/HR/arrhythmias/CHF/unstable angina, anticoagulant therapy >3, intracranial HTN, glaucoma and retinal detachment
TCAs interact with ECT by…
anticholinergic effects = exaggerated CV response
MAOIs interact with ECT by…
exaggerated response - indirect sympathomimetic, fatal with demerol, prolonged succ (>3 months minimal CV response,
SSRI interact with ECT by …
NONE!
Lithium interact with ECT by…
potentiates barbs and succ, possible acute organic brain syndrome, should be stopped 36-48 hours before treatment, fatal with demerol
BP responses with ECT
Tachycardia and hypertension more common, may pretreat with glyco or atropine if at risk for brady
AFib and ECT?
HR should be about 70, anticoagulated to INR 2-3
Induction agent and succ should be based on ___ body weight
ideal
Bite block should be inserted after disappearance of ____ and removed immediately after relief of ____
fasciculation, masseter spasm
Airway pressure should not exceed ____ cm of water
20
Drug of choice for ECT
Methohexital, fast wake up with minimal effects but does suppress the seizure threshold