EBM

Question 1

How does FSh binding affect granulosa cells?

Answer 1

1. Causes Cholesterol release into StAR channel. Cholesterole is converted to P5 with CYP114, P5 is the converted to P4 with 3B-HSD
2. There is an upregulation of CYP19 (aromatase). Androgens and T from thecca cells are then converted to E and secreted

Question 2

What does E2 do to the GnRH pulse freq?

Answer 2

it increases it, which is why FSH secretion is way more wrecked than LH by the E2 negative feedback. Both LH and FSh decrease, but FSH decreases way more.

Question 3

What would an ER antagonist to to the GnRH pulse freq?

Answer 3

GnRH pulse gen is SLowed down. It also ablates the negative feedback of E2, leading to a spiked increase production of FSh and a normal increase production of LH. Note that if you jsut gave a CYP19 inhibitor, you would lower E2 production, which would still be perceived as less Es, which makes GnRH pump more slowly and yet again spikes FSH production (and casually increases LH production)