EBD II Flashcards
How can biomaterials be classified?
MART
By material
By application
By risk
By tissue interaction
Examples diff types materials
Polymers - denture bases/ impression material
Ceramics and glass
Composites
What factors are considered when thinking about risk?
Risk of type of exposure -
surface/skin contact, blood contact?
Risk length exposure - temporary, days, permanent
What are categories of risk?
I- low
II - intermediate
III - high risk
Why is a dental implant IIb?
Higher risk as contact with bone
What are ways of testing biocompatibility?
In-vitro - cell-free model
In-vivo- testing in animals
Clinical testing and trial. (pre-market)
Post-market surveillance
Why are biocompatibility test important?
Lead to process of awarding CE mark
What is used for post-market surveillance?
Adverse reaction reporting project
Adv and disadv of in-vitro testing?
Adv: rapid, cost-effective, reproducible, ethically non-controversial
Didadv: poor model of complex situation
Adv and disadv in-vivo testing?
Adv: whole complex animal model
Disadv: expensive, ethical controversy, not always reliable model of human body
What is often required by law when testing biocompatibility?
In vivo-testing
Adv and disadv clinical trials?
Adv: humans used
Disadv: expensive, ethical issues, may not represent real clinical practice
Why may clinical trials not represent general practice?
Specialist clinicians often used
Pt selection
Time/financial restraints vary
Adv of post-market surveillance?
Can provide early warning of hazzard/ side effects
Can highlight rare adverse reactions
Strengthen evidence base
Is post-market surveillance required by law?
Yes- implementation can be hard
