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Question 1

causes of malabsorption

Answer 1

• lack of digestive enzymes - decetive intraluminal digestion

Question 2

causes of defective intraluminal digestion

Answer 2

• pancreatic insufficiency - pancreatitis + - defective bile secretion - bile obstruction + ileal reesection - bacterial overgrowth

Question 3

pathophysiology of coeliac disease

Answer 3

gliadin in wheat presented to APC -> formation of toxic T cells + gliadin antibodies –> enterocyte injury -> loss of epithelial cells –> malabsorption due to loss of absorptive area.

Question 4

what are the 2 most common functional gut disorders

Answer 4

1. IBS - bowel 2. functional dyspepsia - stomach

Question 5

what is a functional gut disorder

Answer 5

chronic GI symtpoms in the absence of organic disease to explain the symptoms

Question 6

T/F women are more likely to have functional gut disorders

Answer 6

True linked to hormonal changes

Question 7

define dyspepsia

Answer 7

gastric symptoms in the upper abdomen

Question 8

define dyspepsia

Answer 8

gastric symptoms in the upper abdomen

Question 9

symptoms of IBS

Answer 9

• chronic frequent abdo pain - altered bowel habit - bloating communly associated

Question 10

T/F IBS pts should also be tested for coeliac disease

Answer 10

True - IBS symptoms are v similar to coeliac, so should be ruled out

Question 11

IBS differentials

Answer 11

• ovarian - Ca-125 test - coeliac TTA/G??

Question 12

what are the ALARM features of gastric disorders

Question 13

T/F IBS + IBD symptoms do not wake pts up from their sleep

Answer 13

FALSE IBD pts will experience symptoms all through the night while IBS pts won’t as its a disorder linking the brain and the gut so one the brain sleep so does the gut

Question 14

what is faecal calprotectin

Answer 14

marker of gut inflammation

Question 15

what is post-infectious IBS

Answer 15

IBS that occurs after an bout of gastroenteritis.