EAS Flashcards
Ring Activating also means (3)
e- donating
Ortho/para directing
More reactive
Ring dectivating also means (3)
e- withdrawing
meta directing
less reactive (than EDG)
Halogens (2)
Slightly deactivating
Ortho / para directing
Can meta directors under go friedel crafts reactions?
No

Bromination or Chlorination

Nitration
Fuming H2SO4 or

Sulfonation

Friedel-Crafts Alkylation

Friedel-Crafts Acylation

Ring Activating
EDG
o/p directors
More reactive than EWG

Ring deactivating
EWG
meta directors
Less reactive that EDG



Acylate the amine to monohalogenate
How do you prevent overalkylation in Friedel-Crafts
Large excess of benzene
Is overacylation a problem in Friedel-Crafts
No

Reduction of NO2 to NH2

Reduce ketone
Acidic conditions

Reduce ketone
Basic conditons
How do you reduce a “O=” ketone without changing NO2 to NH2
Wolf Kishner


Turn Benzyllic hydrogens into carboxylic acid
