EAS Flashcards

1
Q

Ring Activating also means (3)

A

e- donating

Ortho/para directing

More reactive

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2
Q

Ring dectivating also means (3)

A

e- withdrawing

meta directing

less reactive (than EDG)

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3
Q

Halogens (2)

A

Slightly deactivating

Ortho / para directing

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4
Q

Can meta directors under go friedel crafts reactions?

A

No

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5
Q
A

Bromination or Chlorination

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6
Q
A

Nitration

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7
Q

Fuming H2SO4 or

A

Sulfonation

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8
Q
A

Friedel-Crafts Alkylation

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9
Q
A

Friedel-Crafts Acylation

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10
Q
A

Ring Activating

EDG

o/p directors

More reactive than EWG

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11
Q
A

Ring deactivating

EWG

meta directors

Less reactive that EDG

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12
Q
A
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13
Q
A

Acylate the amine to monohalogenate

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14
Q

How do you prevent overalkylation in Friedel-Crafts

A

Large excess of benzene

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15
Q

Is overacylation a problem in Friedel-Crafts

A

No

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16
Q
A

Reduction of NO2 to NH2

17
Q
A

Reduce ketone

Acidic conditions

18
Q
A

Reduce ketone

Basic conditons

19
Q

How do you reduce a “O=” ketone without changing NO2 to NH2

A

Wolf Kishner

20
Q
A

Turn Benzyllic hydrogens into carboxylic acid