Ear, Nose and Throat Flashcards

1
Q

What is Benign Paroxysmal Positional Vertigo?

A

BPPV is the most common cause of vertigo, which is a spinning sensation that occurs when changing head position

It occurs when small crystals (otoliths) in the inner ear become dislodged and stimulate the vestibular system, which controls balance and orientation

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2
Q

H&E of BPPV

A
  • Recurrent episodes of vertigo lasting <1 minute
  • Triggered by head movements such as rolling over in bed, looking up, or bending over
  • Negative HINTS examination
  • No symptoms of hearing loss, tinnitus or neurological deficits
  • Dix-Hallpike test is the first-line diagnostic test which is preformed to elicit nystagmus from BPPV
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3
Q

Investigations for BPPV

A
  • First line is Dix-Hallpike test
    • Latent and fatiguable nystagmus
  • Additional testing to rule out other causes of vertigo
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4
Q

Management of BPPV

A
  • Particle repositioning manoeuvres, such as Epley manoeuvre or the Semont manoeuvre
  • Home exercises (Brandt-Daroff)
  • Referral to balance specialist if unresolving and resistant to manoeuvres
  • Education about avoiding head positions that can caused BPPV
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5
Q

What is Tonsilitis?

A

Infection and inflammation of the tonsils

Viral causes:
- Rhinovirus
- Adenovirus
- Respiratory Syncytial Virus

Bacterial causes:
- Group A Streptococcus

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6
Q

What are the risk factors for Tonsilitis?

A
  • 5-15 year olds
  • Crowded environments
  • Winter/early Spring
  • Incomplete Abx course
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7
Q

H&E for Tonsilitis

A

Viral:
- low grade fever
- cough
- rhinorrhoea

Bacterial:
- high grade fever
- sore throat
- odynophagia, dysphagia

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8
Q

What is the Fever-PAIN and CENTOR grading system for Tonsilitis?

A

Both 1 point each -
Fever
P - Pus
A - Attend rapidly <3 days
I - Inflamed tonsils (severe)
N - No cough or coryza

C - Can’t cough
E - Exudate (tonsillar)
N - Nodes (ant. cervical lymphadenopathy)
T - Temperature > 38
OR (age < 15 = +1, OR age > 44 = -1)

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9
Q

Investigations for Tonsilitis

A

Confirm diagnoses if high risk of rheumatic fever, very old/young, immunosuppressed or very severe

  • Rapid antigen group A strep test - RAST
  • Culture if negative
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10
Q

Management of Tonsilitis

A

If Fever-PAIN is 0-1 or CENTOR is 0-2:
- do not offer antibiotic

If Fever-PAIN is 2-3:
- Consider no Abx or backup prescription

If Fever-PAIN is 4-5, or CENTOR is 3-4:
- consider immediate Abx
- Phenoxymethylpenicillin
- If allergic - clarithromycin OR erythromycin (if pregnant)

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11
Q

Complications of Tonsillitis

A
  • otitis media
  • quinsy - peritonsillar abscess
  • rheumatic fever and glomerulonephritis very rarely
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12
Q

NICE recommendations for surgical intervention of Tonsillitis

A
  • sore throats are due to tonsillitis (i.e. not recurrent upper respiratory tract infections)
  • the person has five or more episodes of sore throat per year
  • symptoms have been occurring for at least a year
  • the episodes of sore throat are disabling and prevent normal functioning
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13
Q

What is Epistaxis and types?

A

Nose bleeds - bimodal onset - <10yo or 45-65yo

Anterior - Kisselbach’s plexus (Little’s area)
Posterior - Sphenopalatine artery

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14
Q

Causes of Epistaxis

A

Common:
- Idiopathic
- Nose picking
- Trauma
- Age-related

Uncommon:
- Irritants
- Anticoagulants/ anti platelets

Rare:
- Sinonasal neoplasm
- Coagulopathy
- Hereditary haemorrhagic telangiectasia

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15
Q

H&E of Epistaxis

A
  • Blood at back of throat if posterior (even if anterior packed)

Red flags:
- Obstruction
- Serosanguinous discharge

ABCDE approach

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16
Q

Investigation for Epistaxis

A

Examine with thudicum nasal speculum +/- endoscopy

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17
Q

Management of Epistaxis

A
  • IV access for crystalloids for hypovolaemia
  • Hippocratic method - lean forwards and pinch anterior nares, hold for 20 mins
  • Cauterise anterior point bleeds with silver nitrate
  • Anterior packing for multiple bleeds - nasal tampon or gauze in paraffin
  • Bilateral anterior packing +/- posterior packing (oleg catheter)
  • Arterial ligation for unresolving bleeds
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18
Q

Features of Acute Haemolytic Transfusion Reaction

A
  • Fever
  • Hypotension
  • Chest pain
  • Timing of blood product delivery
  • Change in urine colour
19
Q

Management of Anaphylaxis during blood transfusion

A

Stop the transfusion

IM adrenaline

ABC support - oxygen, fluids

20
Q

Description and Management of Transfusion-associated circulatory overload (TACO)

A

Excessive rate of transfusion or pre-existing HF - causes pulmonary oedema and HT

Slow or stop transfusion

Consider IV loop diuretic (e.g. furosemide) and oxygen

21
Q

Description and Management of Transfusion-related acute lung injury (TRALI)

A

Non-cardiogenic pulmonary oedema, due to increased vascular permeability caused by host neutrophils activated by substances in donated blood - leads to hypoxia, fever, HYPOtension and pulmonary infiltrates

Stop transfusion
Oxygen and supportive care

22
Q

Description and Management of Non-haemolytic febrile reaction

A

Caused by antibodies reacting with white cell fragments in the blood product and cytokines that have leaked from blood cell during storage - causes fever and chills
RBC transfusion - 1-2%
Platelet transfusion - 10-30%

Slow or stop transfusion
Paracetamol
Monitor

23
Q

Description and Management of Minor Allergic Reaction during Transfusion

A

Caused by foreign plasma proteins - pruritis and urticaria

Temporarily stop transfusion
Antihistamine
Monitor

24
Q

Causes of Iron Deficiency Anaemia

A

Reduced uptake - IBD, malnutrition, coeliac disease

Increased loss - GI malignancy, IBD, malnutrition, peptic ulcer disease

Increased demand - pregnancy, breastfeeding

25
Signs + Symptoms of Iron Deficiency Anaemia
- Fatigue - SOB - Pallor - Palpitations - Atrophic Glossitis - Post-cricoid webs - Angular stomatitis - Koilonychia
26
Investigations of Iron Deficiency Anaemia
FBC - hypochromic microcytic anaemia Blood film - pencil cells, anisopoikilocytosis (different sizes and shapes), hypochromic, microcytic, target cells Serum ferritin - low Total iron binding capacity/ transferrin - high (as less iron bound)
27
Management of Iron Deficiency Anaemia
- Treat underlying cause - Oral ferrous sulphate - continue 3 months after iron levels replenish - Iron-rich diet
28
Causes of Anaemia of Chronic Disease
Chronic disease state: infection, malignancy, diabetes, autoimmune disorders
29
Signs + Symptoms of Anaemia of Chronic Disease
- Fatigue - Pallor - SOB with physical activity
30
Investigations of Anaemia of Chronic Disease
FBC - low Hb Serum Iron < 15 TIBC - low Ferritin - normal or high BLood film - starts normocytic then leads to microcytic
31
Causes of Normocytic Anaemia
- Acute blood loss - Anaemia of chronic disease - CKD (erythropoietin deficiency) - Aplastic anaemia - Haemolytic anaemia
32
Hereditary causes of Haemolytic Anaemia
Membrane : spherocytosis/ elliptocytosis Metabolism : G6PD deficiency Haemoglobinopathies : sickle cell, thalassaemia
33
Causes of Acquired Immune Haemolytic Anaemia
Coombs-positive Autoimmune : warm/ cold antibody type Alloimmune : transfusion reaction, haemolytic disease of newborn Drug : methyldopa, penicillin
34
Causes of Acquired Non-immune Haemolytic Anaemia
Coombs-negative MAHA : TTP/HUS, DIC, malignancy, pre-eclampsia Prothetic heart valves Malaria Drug : Dapsone Zieve syndrome
35
What is Zieve Syndrome?
Rare clinical syndrome of Coombs-negative haemolysis, cholestatic jaundice and transient hyperlipidaemia associated with heavy-alcohol use Typically resolves with abstinence from alcohol
36
Management of Normocytic Anaemia
Treat underlying cause Supportive Care
37
What is Beta-thalassaemia Major?
- Absence of beta globulin chains - On chromosome 11 - Beta-thalassaemia trait is autosomal recessive
38
Features of Beta-thalassaemia Major
- Present in the first year of life with failure to thrive and hepatosplenomegaly - Microcytic anaemia - HbA2 and HbF raised - HbA absent
39
Management of Beta-thalassaemia
Repeated Transfusion but this can lead to iron overload and then organ failure so iron chelation is important alongside e.g. desferrioxamine
40
What is Alpha-thalassaemia?
Deficiency of alpha chain in Hb
41
Severity of Alpha-thalassaemia
2 separate alpha-globulin genes are on each chromosome 16 1/2 alleles affected - hypochromic and microcytic but Hb typically normal 3 alleles affected - hypochromic microcytic anaemia with splenomegaly - Hb H disease 4 alleles affected (i.e. homozygote) - death in utero (hydrops fetalis, Bart’s hydrops)
42
Causes of Megaloblastic Macrocytic Anaemia
Vitamin B12 deficiency - anaemia and neuro symptoms (affecting legs more than arms) Folate Deficiency REPLACE B12 FIRST
43
What is Sub-Acute Cord Degeneration?
Caused by B12 deficiency - loss of proprioception and vibration, absent ankle jerk reflexes and peripheral neuropathy
44
Causes of Normoblastic Macrocytic Anaemia?
- Alcohol - Liver disease - Hypothyroidism - Pregnancy - Reticulocytosis - Myelodysplasia - Drugs e.g. azathioprine