EAA and Excitotoxicity Flashcards
1
Q
What is the function of Mg in the NMDA channels?
A
It make the receptor both ligand gated and voltage gated because you need the glutamate AND action potential to open the gate.
2
Q
What is the function of the PCP binding site in the NMDA receptor?
A
It blocks the channel. Ex - horse tranquilizer
3
Q
What are the two types of non-NMDA ionotropic receptors?
A
- ) AMPA
2. ) Kainate
4
Q
What are the ligands for AMPA?
A
Glutamate and aspartate (EAA’s)
5
Q
What happens when a ligand binds to AMPA?
A
Na influx
6
Q
Benzodiazepines have what affect on AMPA?
A
If they bind to AMPA, they reduce the amount of sodium that enters.
7
Q
What kind of receptor is Kainate?
A
non-NMDA ionotropic receptor
8
Q
What happens when Kainate is stimulated by an EAA?
A
Na+ and Ca ++ are allowed into the cells
