E3. HLD r2 Flashcards
Atorvastatin 40-80 mg
High Intensity Statin
Atorvastatin 10-20 mg
moderate-intensity statin
Rosuvastatin 20-40 mg
High Intensity Statin
Rosuvastatin 5-10 mg
Moderate-Intensity Statin
Simvastatin 20-40 mg
Moderate Intensity Statin
Pravastatin 40-80 mg
Moderate-Intensity Statin
Lovastatin 40 mg
Moderate Intensity Statin
Fluvastatin 80 mg
Moderate Intensity Statin
Pitavastatin 2-4 mg
Moderate Intensity Statin
Pleiotropic Effects of Statins
- Improve Endothelial Function
- Atherosclerotic plaque stabilization
- Decrease oxidative stress and inflammation
- Inhibit Thrombogenic response.
Simvastatin 10 mg
Low-Intensity Statin
Pravastatin 10-20 mg
Low-Intensity Statin
Lovastatin 20 mg
Low-Intensity Statin
Fluvastatin 20-40 mg
Low-Intensity Statin
Pitavastatin 1 mg
Low-Intensity Statin
Active Liver Disease
Unexplained elevated transaminases (3x ULN)
Pregnant or Nursing Women
Major Drug Interactions
Statin Contraindications.
Pravastatin and Rosuvastatin
Hydrophillic Statins
Atorvastatin, Lovastatin, and Simvastatin
CYP3A4 substrates
Atorvastatin, Pitavastatin, and Rosuvastatin
Long Half-Lives.
Statin Benefit Groups.
- 40-75 w/ 70-190 LDL no DM
- LDL >190 mg/dL
- Diabetes
- Secondary Event
Non-Statin Benefit Group (possibly primary prevention)
- LDL >160 mg/dL
- History of premature ASCVD
- High CRP (>2 mg/dL)
Categorize This Risk Category.
- Progressive ASCVD after achieving LDL <70
- Established CVD w/ DM, CKD, HeFG
- History of premature ASCVD (<55 (m), <65 (F)
Extreme Risk
Categorize this risk category.
1. Recent Hospitalization for (ACS, Coronary Disease, PAD)
- ASCVD >20%
- Diabetes/CKD + 1 Risk Factor
Very High Risk
Categorize this risk category.
- 2+ RF for ASCVD + 10-20% ASCVD risk
- Diabetes/CKD w/ no RF.
High Risk
Extreme Risk LDL Goal
<55 mg/dL
Very High Risk LDL Goal
<70 mg/dL
High Risk LDL Goal
<100 mg/dL
