E2: Renal: Maternal Adaptations Flashcards
What is the Filtration Fraction
Filtration Fraction = GFR/RPF
Where does water stay in within the tubule?
Where is water reabsorbed?
Descending Loop: Water reabsorption
Ascending Loop: Water stays in
Describe the change observed in Renal Plasma Flow (RPF) & Glomerular Filtration Rate (GFR) during pregnancy & PostPartum
Both GFR & RPF increase during Pregnancy in W1-20
RPF, however, Begins declining during pregnancy while GFR remains stable.
Both decrease during PP.
How does Relaxin affect GFR & RPF?
What about Renal Vascular Resistance?
Relaxin increases both GFR & RPF
Relaxin Decreases Renal Vascular Resistance
- Pregnancy is a profoundly ____ state.
- ___ is a potent Vasodilator that contributes to maternal vasodilation of pregnancy
- Vasodilated state
- Relaxin
What factors contribute to Sodium retention? (Antinatriuretic factors)
- Aldosterone
- Estrogen
- Deoxycorticosterone
- Supine & Upright posture
- Na/K Transport increase
What factors promote sodium excretion? (Natriuretic factors)
- Glomerular Filtration Rate (GFR)
- Progesterone
- Prostaglandins
- Atrial Natriuretic Factor
How do estrogens affect sodium reabsorption?
Estrogens
-> Increased AGT -> Increased ANG II -> Increased ANG (1-7) -> Vasodilation -> Increased Renal Renin -> Increased Sodium Reabsorption
How does Relaxin affect sodium reabsorption?
Relaxin
- > Vasodilation -> Increased Renal Renin -> Increased sodium Reabsorption
- > Increased RBF -> Increased GFR -> Increased Sodium Excretion
How does Progesterone affect sodium reabsorption?
Progesterone
- > Decreased response to Angiotensin -> Decreased Sodium Reabsorption
- > Stimulates NO synthase -> Increased Vasodilation -> Reduces BP -> Increases Aldosterone -> Increase blood volume -> Increases GFR & RBF
How do ANGII & ANG (1-7) levels differ between pregnant & Non-pregnant women?
How does Atrial Natriuretic Peptide (ANP) change during pregnancy?
