E2 - Acid-Base Disorders Flashcards
In order to ensure optimal function of enzymatic function, acid-base balance is tightly regulated at what pH?
- 7.35 to 7.45
What causes acidemia?
- Excess production of H+ (in relation to hydroxyl ions)
What causes alkalemia?
- Excess production of OH- (in relation to hydrogen ions)
What is known as the measured hydrogen concentration?
- pH
The Power of Hydrogen
The stability of pH is managed by what three factors?
- CO2 (enters/leaves the body via lungs)
- HCO3 (enters/leaves the body via kidneys
Via proximal tubule) - H+ (reabsorbed Via distal tubule and collecting duct)
What is the equation to calculate pH?
pH = 6.1 + log [serum bicarb/(0.03 x PaCO2)]
How can you tell if an acid-base disorder is a primary disorder with secondary compensation?
A. PaCO2 and HCO3 are equal
B. PaCO2 and HCO3 change in opposite direction
C. Both PaCO2 and HCO3 change in the same direction
C. Both PaCO2 and HCO3 change in the same direction
How can you tell if an acid-base disorder is a mixed acid/base problem?
A. PaCO2 and HCO3 are equal
B. PaCO2 and HCO3 change in different direction
C. Both PaCO2 and HCO3 change in the same direction
B. PaCO2 and HCO3 change in different direction
What is the Acid/Base Disorder
pH: 7.34
PCO2: 48
HCO3: 24
Uncompensated Respiratory Acidosis
What is the Acid/Base Disorder
pH: 7.58
PCO2: 38
HCO3: 29
Uncompensated Metabolic Alkalosis
What is the Acid/Base Disorder
pH: 7.28
PCO2: 42
HCO3: 18
Uncompensated Metabolic Acidosis
What is the Acid/Base Disorder
pH: 7.48
PCO2: 32
HCO3: 22
Uncompensated Respiratory Alkalosis
If your patient has normal lungs, what should their PaO2 be when they are on 60% FiO2?
- PaO2: 240 to 300 mmHg
Normal range of PaO2: 80-100 mmHg
FiO2 of room air is 21%
FIO2 of 60% is about 3x of room air.
PaO2 will be between 240-300 mmHg
Cardiovascular Consequences of Acidosis
- Impaired contractility at pH 7.2
- Decreased contractility
- Decreased arterial blood pressure
- Sensitive to re-entry dysrhythmias
- Decrease threshold for V-fib
- Decreased responsiveness to catecholamines at pH 7.1
Nervous System Consequence of Acidosis
- Obtundation
- Coma
Pulmonary Consequences of Acidosis
- Hyperventilation (d/t compensation, blowing off CO2)
- Dyspnea
- Respiratory Muscle Fatigue
Metabolism Consequence of Acidosis
- Hyperkalemia (contributes to reentry dysrhythmias)
- Insulin Resistance
- Inhibition of anaerobic glycolysis
Define Respiratory Acidosis
- An acute decrease in alveolar ventilation resulting in increase PaCO2
- pH < 7.35
- Caused by respiratory failure
What are the causes of Respiratory Acidosis?
- Drug-induced ventilatory depression
- Permissive hypercapnia
- Upper airway obstruction
- Status asthmaticus
- Restriction of ventilation (rib fx, flail chest)
- Disorder of neuromuscular function
- MH
- PNA/ Pulmonary Edema, Pleural Effusion
What are the 3 causes of respiratory acidosis r/t anesthesia management?
A. excess bicarb administered
B. inadequate NMBD reversal
C. therapeutic hyperventilation
D. opioid excess
E. CO2 insufflation
F. consequence of pain
B. inadequate NMBD reversal
D. opioid excess
E. CO2 insufflation
What are the three categories that can cause Respiratory Acidosis?
- Central ventilation control (neuro disorder/drug induced vent depression)
- Peripheral ventilation control (neuromuscular disease)
- VQ mismatch (Pneumonia)
what is a reason that a patient would have slow, shallow breathing ultimately leading to respiratory acidosis?
A. pneumothorax
B. atelectasis
C. sleep apnea
D. somnolence d/t residual opioids
D. somnolence d/t residual opioids
what is a peripheral problem that would cause a patient to have rapid, shallow breathing ultimately leading to respiratory acidosis?
A. hemo/pneumothorax
B. bronchospasm
C. sleep apnea
D. residual opioid causing somnolence
A. hemo/pneumothorax
what is a reason that a patient would have obstructed breathing ultimately leading to respiratory acidosis?
A. residual NM blockade
B. high spinal
C. bronchospasm
D. atelectasis
C. bronchospasm
In acute hypercarbia, if the PaCO2 increases by 10 mmHg, how much will the HCO3 increase for the system to be compensated?
A. 3 mEq/L
B. 10 mEq/L
C. 1 mEq/L
D. 5 mEq/L
C. for every 10 mmHg of PaCO2, bicarb should increase by 1 mEq/L
10:1 in acute hypercarbia
10:3 in chronic hypercarbia
takes about 2-3 days for kidneys to increase bicarb levels in order to compensate
In chronic hypercarbia, if the PaCO2 increases by 10 mmHg, how much will the HCO3 increase for the system to be compensated?
A. 3 mEq/L
B. 10 mEq/L
C. 1 mEq/L
D. 5 mEq/L
A. 3 mEq/L
10:3 in chronic hypercarbia
10:1 in acute hypercarbia
This is prevalent in COPD patients
Upon arrival at the ICU, the patient has a PaCO2 of 80 mmHg.
What is the expected HCO3 if this patient has compensated acute hypercapnia?
- 28 mEq/L
Normal PaCO2 level: 40 mmHg
Normal HCO3 level: 24 mEq/L
PaCO2 of the patient is 80 mmHg
PaCO2 increased by 40 mmHg
For acute hypercapnia, ↑PaCO2 of 10 mmHg=↑HCO3- of 1 mEq