E1- Drugs of Abuse Flashcards
What is the MOA of Adderall and Ritalin?
Increase release of DA (reverses DA transport through the DAT)
What are the uses of Adderall and Ritalin?
Narcolepsy
ADHD
What is the MOA of Cocaine?
inhibits DA reuptake
What are the medical uses of cocaine?
Local anesthetic, vasoconstrictor
What can be given in recovery of cocaine addiction to decrease cravings?
Bromocriptine
What are treatments for nicotine addiction?
Nicotine Replacement Therapy (NRT)
Bupropion (Zyban)
Varenicline (Chantix)
What is the MOA of NDMA?
Increase 5-HT activity by blocking reuptake and stimulating 5-HT receptors
What is the MOA of marijuana?
Stimulates presynaptic CB1 receptors to inhibit transmitter (ACh) release
Which drugs do not lead to physical dependence?
Marijuana, LSD
What are SE of marijuana?
Amotivational syndrome
Cannabinoid hyperemesis: cyclic vomiting syndrome
Bronchial irritation, risk of CA
Decreased ovulation and testosterone/sperm production
Low birth weight and fetal malformations
Which drug can cause synesthesia?
one sensory modality assumes the characteristics of another (colors can be heard, or sounds can be seen)
LSD
What is the MOA of PCP and Ketamine?
NMDA receptor antagonist
What is the MOA of GHB?
GABA receptor weak agonist
What drug often produces psychosis? How do you treat it?
PCP
Haloperidol
Which drug can cause peripheral neuorpathy with chronic use?
Nitrous oxide
