Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology 3 > E1- Antidepressants > Flashcards

E1- Antidepressants Flashcards

1
Q

What drugs are classified as TCAs?

A

Amitriptyline
Imipramine
Nortriptyline
Desipramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the MOA of TCAs?

A

Inhibit reuptake of NE and 5-HT; also block alpha, histamine, and muscarinic receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the uses of TCAs?

A

Depression (2nd to last choice)
Chronic pain (TMJ) Fibromyalgia
Enuresis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the tertiary amine TCAs?

A

Amitriptyline

Imipramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the secondary amine TCAs? (primarily block NE re-uptake)

A

Nortriptyline

Desipramine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Do tertiary or secondary amines produce more seizures and are more sedating?

A

Tertiary amines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How are TCAs metabolized?

What should you avoid?

A

CYP2D6 (do not take with Fluoxetine- inhibits 2D6)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are SE of TCAs?

A 
Weight gain
Antihistamine effects
Anticholinergic effects
Alpha blocker effects 
Analgesia
SIADH
Sexual dysfunction
Decreased seizure threshold
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Are TCAs safe in pregnancy?

A

Yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is seen with TCA OD? How is it treated?

A

Torsades de pointes

Magnesium, isoproterenol, and cardiac pacing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are TCA drug interactions?

A 
Fluoxetine (inhibits metabolism)
MAOIs (serotonin syndrome)
SSRIs
Amphetamines (HTN)
Alcohol/CNS depressants (sedation)
Anticholinergics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What drugs are classified as SSRIs?

A 
Fluoxetine
Sertraline
Paroxetine
Citalopram
Escitalopram
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the MOA of SSRIs?

A

Selectively inhibit the reuptake of 5-HT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the uses of SSRIs?

A 
Depression
Panic disorder
Bulimia
Alcoholism
Obsessive-compulsive disorder & social anxiety = Paroxetine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are SE of Fluoxetine?

A 
Inhibits CYP2D6 (most drug interactions of SSRIs)
Impairs blood glucose in diabetics
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which SSRI is least likely to cause drug interactions and preferred in the elderly?

A

Sertraline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is DOC for depression?

A

Citalopram

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are SE of SSRIs?

A

Weight gain/loss
GI: nausea, loss of appetite, constipation
Anxiety/insomnia (Fluoxetine or Sertraline)
Sexual dysfunction
Photosensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Because SSRIs inhibit CYP3A4 and 2D6, what drug interactions should you watch for?

A

TCAs
Phenytoin
Carbamazepine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What drug interactions of SSRIs can cause serotonin syndrome?

A

St. John’s Wort
Amphetamines
MAOIs
Meperidine (opioid)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What drug interaction of SSRIs can cause heart block and hypotension?

A

B-blockers

22
Q

Fluoxetine can inhibit the conversion to the active compound of what drug?

A

Codeine (opioid)

23
Q

What drug interaction of SSRIs can increase risk of seizures?

A

Tramadol

24
Q

What drugs are classified as SNRIs?

A

Venlafaxine

Duloxetine

25
Q

What is the MOA of SNRIs?

A

Inhibit reuptake of NE and 5-HT

26
Q

What are the uses of SNRIs? (3)

A

Depression
Neuropathic pain
Post-menopausal hot flashes

27
Q

What drugs are classified as MAOIs?

A

Phenelzine

Selegiline

28
Q

What is the MOA of MAOIs?

A

Irreversibly inhibit MAOs

29
Q

MAO-A metabolizes what?

A

NE, DA, and 5-HT in both the CNS and GI tract

30
Q

MAO-B metabolizes what?

A

DA in the CNS, but not the GI tract

31
Q

What is the MOA of Phenelzine?

A

Inhibits both MAO-A and MAO-B (increases NE, 5-HT and DA)

32
Q

What is the use of Phenelzine?

A

Depression that has not responded to other drugs (LAST choice)

33
Q

What is the MOA of Selegiline?

A

Selectively inhibits MAO-B (increases DA)

34
Q

What are the uses of Selegiline?

A

Depression that has not responded to other drugs (LAST choice)
Parkinson’s

35
Q

What are SE of MAOIs?

A 
HTN crisis (Phenelzine)
-Avoid foods with tyramine (red wine, beer, aged cheese)
Orthostatic hypotension
Weight gain
Anticholinergic effects
36
Q

What drug interactions of MAOIs can lead to serotonin syndrome/hyperpyrexia?

A

TCAs
SSRIs
Meperidine
Dextromethorphan

37
Q

What drug interactions of MAOIs can lead to severe HTN?

A

OTC cold/cough medications Phenylephrine
Ephedrine
Amphetamines

38
Q

What is the MOA of Bupropion?

A

Inhibits DA reuptake

39
Q

What are uses of Bupropion?

A

ADHD
Alcoholism
Extended release for smoking cessation (Zyban)

40
Q

What are SE of Bupropion?

A

Seizures
Anxiety, insomnia, restlessness, tremor, psychosis
Tachycardia

41
Q

What is the MOA of Mirtazapine?

A

Blocks presynaptic alpha2 receptors –> increase release of NE 5-HT

42
Q

What are uses of Mirtazapine?

A

Eliminates SE associated with SSRIs

good choice for depressed pt with insomnia and anxiety

43
Q

What is the MOA of Atomoxetine?

A

Selective inhibitor of NE reuptake

44
Q

What is the use of Atomoxetine?

A

First non-stimulant tx of ADHD (good choice for addicts, no euphoria)

45
Q

What is the MOA of Trazodone?

A

5-HT2A receptor antagonist

46
Q

What are the uses of Trazodone?

A

Sleep aide and pain management

47
Q

What is a SE of Trazodone?

A

Priapism

48
Q

What may be effective in the tx of mild depression?

A

St. John’s Wort

49
Q

What is a SE of St. John’s Wort?

A

Photosensitivity

50
Q

What are drug interactions of St. John’s Wort?

A 
DO NOT combine with other antidepressants (serotonin syndrome)
Oral contraceptives
Digoxin
Protease inhibitors
Warfarin

Pharmacology 3 (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions