E01L02 Mechanisms of Drug Action

Question 1

_______-____-_____ _____ implies that # of receptors may limit max effect of drug

Answer 1

sigmoid-dose-response curve

Question 2

True about Receptor-mediated drug action except
A. All receptors are protein
B. Specificity is due to shape and electrical charge via structural diversity
C. has 2 major domains - receptor and effector
D. Can be identified by drug binding and gene sequencing

Answer 2

A

Question 3

[Type of receptor] Neurotransmitters, autocoids, hormones

Answer 3

Regulatory Proteins

Question 4

[Type of receptor] inhibited by drug binding

Answer 4

Enzymes

Question 5

[Type of receptor] e.g. Na-K-ATPase

Answer 5

Transport

Question 6

[Type of receptor] e.g. tubulin - receptor for colchines

Answer 6

Sturctural

Question 7

IUPHAR stands for

Answer 7

International Union of Pharmacology

Question 8

Ach, Serotonin, GABA, glutamate act on
A. Ligand Gated Ion Channels
B. Voltage Gated Ion Channels
C. G-Protein coupled receptors
D. Enzyme-linked receptors

Answer 8

A

Question 9

What is common about Phenytoin, Lamotrigine and Valporate?

Answer 9

Inhibit Na+ channels therefore are used as anticonvulsants

Question 10

What is verapamil for?

Answer 10

Inhibit voltage-gated Ca2+ channels at vascular smooth muscle, decrease BP antiarrhythmic

Question 11

___________ Receptor - no ion but linked to G-receptor

Answer 11

Metabotropic

Question 12

Which of the following statements is false?
A. Gαs open ion channels (Ca2+) in myocardium and skeletal muscle
B. Gi open K+ Channel in heart and smooth muscles
C. Gαs close neuronal Ca2+ channel
D. Gi close neuronal Ca2+ channel

Answer 12

C

Question 13

Physiological ligand for receptor for tyrosine kinase are the following except
A. Insulin
B. PDGF
C. EGF
D. VEGF
E. Interleukin

Answer 13

E

Question 14

Effector of Receptors for tyrosine kinase

Answer 14

SH2 domain

Question 15

Herceptin and Imatinib target

Answer 15

Receptor for tyrosine kinase

Question 16

Interleukin and other cytokines act on

Answer 16

Cytokine receptors

Question 17

Effector of cytokine receptor

Answer 17

Jak/STAT

Question 18

Effetor of guanylylcyclase

Answer 18

cGMP

Question 19

Physiological ligand of guanylyl cyclase

Answer 19

Natriuretic peptides

Question 20

Example drug that targets guanylyl cyclase

Answer 20

Nesiritide

Question 21

Purpose of phsophorylation include the following EXCEPT
A. Amplification
B. Flexible regulation
C. A only
D. Both A and B

Answer 21

D

Question 22

Non-receptor mediated drug action; chelates blood thus used in treating lead poisoning

Answer 22

EDTA

Question 23

Non-receptor mediated drug action; treat fibrotic skin disorder

Answer 23

PABA

Question 24

What is the non-receptor mediated action of KMnO4?

Answer 24

antiseptic

Question 25

What is the non-receptor mediated action of Mannitol?

Answer 25

Osmotic disorder

Question 26

Describe tachyplaxis

Answer 26

diminution of receptor response due to frequent exposure to agonists