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LUIV Ther 201 > E01L01 Introduction to Pharma > Flashcards

E01L01 Introduction to Pharma Flashcards

1
Q

What is the study of drugs or the effects of chemical agents in the function of biologic systems ?

A

Pharmacology

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2
Q

____ is a substance that brings about a CHANGE in BIOLOGIC FUNCTION through its CHEMICAL ACTIONS

A

Drug

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3
Q

_______ ____________ is concerned with the use of chemicals in the prevention, diagnosis and treatment of disease

A

Medical Pharmacology

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4
Q

What do you call the science of poisons or the study of undesirable effects of chemicals on living systems?

A

Toxicology

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5
Q

What Denotes the actions of the drug on the body (i.e what the drug does to the body)

A

Pharmacodynamics

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6
Q

What Describes the actions of biological systems on drugs? (i.e. what the body does to the drug)

A

Pharmacokinetics

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7
Q

Who is the Father of Pharmacology?

A

Oswald Schmiedeberg

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8
Q

Who isolated the first pure glycoside in crystal form from foxglove, which he called “digitoxin” ?

A

Oswald Schmiedeberg

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9
Q

Who isolated a much-purified material he called “digitalin” from foxglove in 1869 6 years after Oswald Schmiedeberg’s “digitoxin”?

A

Nativelle

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10
Q

Boehringer Mannheim (1888), F. Kraft (1912) discovered _______

A

other glycosides of foxglove

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11
Q

Who said that said that “Facts and facts alone are the basis of science“ and wrote the “Formulary for the preparation and mode of employing several new remedies” ?

A

Francois Magendie

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12
Q

Who studied curare and carbon monoxide gas on animals

A

Claude Bernard

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13
Q

Who established the first laboratory for experimental pharmacology in his basement, later moved to the Anatomy Theatre of University of Dorpat (now Tartu University in Estonia)?

A

Rudolph Buchheim

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14
Q

Who coined coined ‘chemotherapy’, started era of antimicrobial therapy?

A

Paul Erlich

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15
Q

Who introduced chemical receptor theory & “receptive substance”?

A

John Newport Langley

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16
Q

Who identified acetylcholine as possible neurotransmitter?

A

Sir Henry Hallet Dale

17
Q

Who is Schmiedeberg’s student, trained many US pharmacologists and is the Father of American Pharmacology?

A

John Jacob Abel

18
Q

Who is the Father of Philippine Pharmacology?

A

Dr. Daniel de la Paz

19
Q

____________ deals with the use of chemotherapeutic agents to inhibit or destroy invading microbes, parasites or cancer cells with minimal effect on healthy living tissues.

A

Chemotherapy

20
Q

________________ deals with genetically mediated variations in drug responses.

A

Pharmacogenetics

21
Q

________ ____________ is a branch of pharmacology that deals with the pharmacological effects of drugs in man.

A

Clinical Pharmacology

22
Q

_______________ deals with the development of new drug delivery systems and new dosage forms.

A

Biopharmaceutics

23
Q

________________ is the use of genetic information to guide the choice of drug therapy on an individual basis.

A

Pharmacogenomics

24
Q

____________________ is the study of drug effects at the population level, and helps in regulation of drugs.

A

Pharmacoepidemiology

25
Q

AGONIST : active conformation of the receptor:: ________: inactive conformation of the receptor

A

ANTAGONIST

26
Q

What is the receptor target of digoxin?

A

Na-K-ATPase

27
Q

Which of the following statements is true about digitoxin?
A. Stimulates renin in the kidney
B. Decreases entrance of Na+ into the cell
C. Increases renal tubular reabsorption of Na+
D. Increase sympathetic outflow from CNS

A

B. Decreases entrance of Na+ into the cell

28
Q

Side effects of digitalis include
A. heart arrythmia
B. GIT anorexia, nausea, vomiting, diarrhea
C. Vagal and chemoreceptor stimulation
D. Disorientation hallucination, visual disturbances
E. AOTA

A

E

29
Q

Therapeutic range of digitoxin

A

therapeutic range: 0.5- 2 ng/ml

30
Q

Digoxin oral bioavailability

A

75%

31
Q

Digoxin Volume of Distribution

A

6.3L/kg

32
Q

Digoxin Half-life

A

40hrs

33
Q

Digoxin Plasma Protein Binding

A

20-40%

34
Q

Digoxin Percent Metabolized

A

40%

35
Q

True about rational drug use

A. Optimization of THERAPEUTIC EFFICACY
B. AVOIDANCE and PREVENTION of toxicity
C. SOCIALLY-RESPONSIBLE prescribing behavior
D. AOTA

A

D

LUIV Ther 201 (2 decks)

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