Dz Flashcards
In which zone does BPH occur?
transition zone
In which zone does prostate cancer occur?
peripheral zone
What is the purpose of DRE?
to check for nodules/cancer
Is DRE helpful for detecting BPH?
NO
What are the type of BPH?
obstructive and irritative
What is obstructive BPH? ie?
mechanical obstruction
ie) Bladder outlet obstruction
dynamic component
ie) adrenergic tone - muscle tone is causing obstruction
What is irritative BPH?
detrusor muscle hypertrophy/hyperplasia
the BLADDER is irritated
How may a pt with BPH come in looking like?
swollen abdomen/bladder
When should peds get imaging done on their kidneys/bladders?
male <2yo
GU anaomolies
recurrent (3+/yr)
What labs should be done for BPH?
Serum creatinine
UA
Serum creatinine would be elevated or decreased in BPH? What next?
elevated
US
UA in BPH? What next?
hematuria
CT urogram
refer to urology
What imaging if considering cancer?
cystoscopy
BPH mild - tx?
mild: nothing
BPH mod- severe - tx?
selective alpha 1a-receptor blocker (not lungs) -tamsulosin (flomax) -alfuzosin (uroxatrol) nonselective alpha blockers (lungs) -terazoin (hytrin) -doxazosin (cardura)
BPH w/ large prostate + hematuria?
5 alpha-reductase inhibitors
6mo until benefit
ADD W/ ALPHA BLOCKER
BPH when to refer?
failed tx cannot urinate recurrent UTI recurrent hematuria renal insufficiency
BPH surgery gold standard?
Transurethral resection of the prostate (TURP)
What does PSA measure?
NOT cancer
protein that is measured in the blood –> if elevated may indicate: infxn, cancer, enlarged prostate
–further eval would be needed
Hypospadias?
failure of the urethral folds to close at the tip of the penis
benign
Hypospadias -refer?
if infant has a strong pee
Hypospadias - tx?
nothing - unless bothersome
Urethral stricture/meatal stenosis?
narrowing of the urethra
Complication from uncircumcised penis?
phimosis pearly penile papules balanitis smegma HPV
Decrease urine stream, spraying/double stream, postvoiding dribbling?
urethral stricture/meatal steonsis
Phimosis?
chronic infxn from poor hygiene
SQUAMOUS CELL CARCINOMA UNDER FORESKIN
Phimosis - tx?
abx
Paraphimosis?
foreskin gets stuck when retracted behind the glans
Paraphismosis - sx/pe?
edema d/t venous congestion
arterial occlusion and necrosis may occur
Paraphismsis - tx?
firmly squeezing glans for 5min to decrease tissue edema
skin can be drawn forward over glans
abx
Curvature of the penis of the painful erection but NO pain when not erected?
peyronie’s dz
Penis is rigid but NOT painful?
nonischemic priaprism
Nonischemic priapism -tx?
observe/self limiting
What should sickle cell pts be aware of?
ischemic priapism
What is happening in ischemic priapism?
venous drainage circulation gets cut off –> build up of viscous and poorly oxygenated blood in copora cavernosa
What drug can cause ischemic priapism?
trazodone
Ischemic priapism - tx?
analgesia + alpha agonist
corporal aspiration
surgical shunt
If pt has sickle cell and ischemic priapism?
treat the underlying sickle cell dz - O2, hydration, transfusion
Where does LH and FSH come from?
anterior pituitary
LH?
leydig –> synthesize testosterone –> secondary characterisitcs
FSH?
sertoli cell –> spermatogensis
Fails at testes?
primary hypergonadotrophic hypogonadism
Primary hypergonadotrophic hypogonadism- LH and FSH?
HIGH
NO negative feedback because testes are broken –> continuos LH and FSH is made but NO testosterone
Secondary hypogonadotrophic hypogonadism?
fails at the gonads
Secondary hypogonadtrophic hypogonadism - LH and FSH?
low LH and FSH –> LOW testosterone
Secondary hypogonadtrophic hypogonadism PE-before puberty?
before puberty- nothing
Secondary hypogonadtrophic hypogonadism PE-after puberty?
after puberty - NO secondary characteristics (hair, narrow shoulders, gynocomastia)
Secondary hypogonadtrophic hypogonadism PE-later in life?
later in life - erectile dysfxn, poor libido, mood changes (depression), low energy
Normal range for testosterone?
300-1,000
What do to if lower than 300 testosterone level?
suspect androgen deficiency
What do you a LH and FSH lab test for those w/have small testes?
to distinguish between primary hypergonadtrophic and secondary hypogondatrophic hypogoandism
When do you tx for hypogonadism?
testosterone is <300
AND 3 sx (erectile dysfxn, poor libido, mood changes, fatigue)
How long do you monitor hypogonadisim tx? What else do you monitor?
after 3 mo + q 3 mo
consider prostate screening, hct, lipids
What are contraindications for testosterone replacement?
incr Hct sleep apnea CHF, MI, unstable angina hx of prostate cancer, breast cancer severe lower urinary tract sx
What form does testosterone replacement come in?
oral buccal patch gel IM
What are DIs for testosterone replacement?
anticoag
antidiabetic
corticosteroids
ACTH
What are the benefits of testosterone replacement?
better mood –> depression
better libido –> libido
decrease erectile dysfunction –> erectile dysfunction
more muscle strength and endurance –> fatigue
What are the treatments for hypogonadism?
testosterone replacement
gonadotropins
Premature gonadal failure vs “andropause”?
premature gonadal failure: ABNORMAL decrease of testosterone in YOUNG males
andropause: NATURAL decrease of testosterone w/age
What are the diff types of testicular dysfxn?
Klinefleter cryptorchidism trauma/torsion mumps/infxn orchitis radiation
What is Klinefleter?
XXY
What is cryptorchidism?
incomplete dropping of the testes
Cryptorchidism -tx?
correct before 2yo - surgery
Cryptorchidism - complication?
Bilateral > unilateral
increase risk for testicular neoplasm
increase risk for inguinal hernias
What is testicular torsion?
twisting of the testes
Testicular torsion - cx?
trauma
growth spurt
tumor
HX OF CRYPTOCHIDISM (complication)
Testicular torsion - population?
<25yo
Testicular torsion - sx/pe?
"bellclapper" testes move freely in the tunica vaginls ACUTE pain swelling asymmetric scrotum
What is the timeframe for testicular torsion saving?
sx w/ 6+hrs = risk of losing testes
What haps if you lose one testes?
other will kick into gear - not a prob
Testicular torsion - test?
cremastric reflex
Testicular torsion - tx?
surgery
manual detorsion
Erection?
parasympathetic
S2-S4
blood flow increases –> presses down on the veins –> blood accumulates –> erection
Ejaculation?
sympathetic
T10-L2
needs both pudendal nerve and skeletal muscle
1) seminal emission
2) projectile ejaculation
–needs both pudendal nerve and skeletal muscle
How to tx premature ejaculation?
- behavioral therapy: stop stimulation just prior to climax and hold base of penis anterior to posterior to prevent emission (kind of like desensitizing)
- SSRI: d/t increase in serotonin
- reduce penile sensitivity: condomn, topical anesthetizing cream
What can cx delayed oragsm?
SSRI
opiates
What is retrograde ejaculation?
backflow of semen into the bladder
Cx of retrograde ejaculation?
after TURP (d/t BPH) alphablockers for BPH
Tx for retrograde ejaculation?
alphasympathomimetics (benadryl)
remove alphablockers
Erectile dsyfunction-types?
organic
psychogenic
What is organic erectile dysfunction?
having the desire but not able to physically get the penis erected
What is pychogenic erectile dysfunction?
not having the desire to get an erection
What must be ruled out before erectile dysfunction?
neurological disorder
- brain lesions
- peripheral neuropathy (diabetes)
Pt comes in erectile dysfunction - what is important to take note of/review?
- meds: SSRI, opiates, non selective beta blockers, antishitamines, H2 blockers
- ETOH drinker
If pt is taking meds for the heart and is having trouble with erections, what drug can be used? avoided?
- change the beta blocker to alpha agonist
- do NOT use sildenfil in case pt needs to take nitro
What pts should have labs done for erectile dysfunction?
ONLY if they are:
- depressed
- fatigue
- libido
Tx erectile dysfunction?
lifestyle changes adjust meds (Beta blockers, SSRI) drugs: PDE 5Is transurethral therapy: alprostadil vacuum pump device intracavernous injection penile implant
What adjustment to meds for erectile dysfunction?
Beta blockers –> alpha agonist
SSRI –> bupropion/wellbutrin, drug holiday, reduce SSRI
What drugs can be used for erectile dsyfunction?
- sildenafil
- verdenafil
- tadalafil
When are the drugs for erectile dysfunction effective?
IF he is aroused
MOA of sildenafil?
increase cGMP levels –> vasodilation
Who may NOT respond to sildenafil?
DM
Sildenfil ADR?
HA flushing GI vision (blue) hypotensive
Sildenfil DI?
NO nitrites
alpha blockers
CYP450
Which tx of erectile dysfunction does NOT need sexual arousal?
intracavernous injection
What are the types of hernias?
groin --> inguinal and femoral incisional hiatal ventral umbilical rectus diastasis
RF for hernias?
CHRONIC COUGH/CONSTIPATION abdominal wall injury HX OF CRYPTORCHIDISM older age male caucasian smoker
Hx of cryptorchidism can cx?
inguinal hernias
testicular torsion
cancer
sterility
Population for hernias?
50yo
Hernia hx/sx?
dull pain when NOT moving
worse w/ moving, heavy lifting, coughing
Hernia PE?
bulge in groin but NON TENDER
Inguinal hernia: direct vs indirect PE?
direct: rounder
indirect: ‘narrow’
Complication of hernia?
if painful:
incarceration –> strangulation –> bowel obstruction
What is incarceration (hernia)?
the bowel gets stuck outside - pain
What is strangulation (hernia)?
bowel AND ischemia starts - blood flow compromised
What is bowel obstruction (hernia)?
BLOCKING of gas/stool - DIFFUSE abdomen pain